HSD17B13 and TREX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HSD17B13	TREX1
Description		hydroxysteroid 17-beta dehydrogenase 13	three prime repair exonuclease 1
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Oligosaccharyltransferase Complex Membrane Protein-DNA Complex Nuclear Replication Fork
	Molecular Function	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor	Magnesium Ion Binding Nucleic Acid Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Nuclease Activity Exonuclease Activity DNA Exonuclease Activity Protein Binding 3'-5'-DNA Exonuclease Activity DNA Binding, Bending Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity MutLalpha Complex Binding MutSalpha Complex Binding Adenyl Deoxyribonucleotide Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding WW Domain Binding
	Biological Process	Lipid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process	DNA Damage Checkpoint Signaling Blood Vessel Development Kidney Development Adaptive Immune Response Organ Or Tissue Specific Immune Response Activation Of Immune Response Macrophage Activation Involved In Immune Response Lymphoid Progenitor Cell Differentiation Immune Response In Brain Or Nervous System Inflammatory Response To Antigenic Stimulus T Cell Antigen Processing And Presentation Regulation Of Immunoglobulin Production Heart Morphogenesis Heart Process Atrial Cardiac Muscle Tissue Development Generation Of Precursor Metabolites And Energy Regulation Of Glycolytic Process DNA Metabolic Process DNA Replication DNA Repair Mismatch Repair DNA Modification DNA Catabolic Process DNA Recombination Inflammatory Response Immune Response DNA Damage Response Determination Of Adult Lifespan Response To UV Regulation Of Gene Expression Regulation Of Fatty Acid Metabolic Process Regulation Of Metabolic Process Mitotic G1 DNA Damage Checkpoint Signaling Retrotransposition Regulation Of Type I Interferon Production Regulation Of Tumor Necrosis Factor Production Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Cellular Response To UV Cellular Response To Interferon-beta Apoptotic Cell Clearance Regulation Of Cellular Respiration Innate Immune Response Regulation Of Innate Immune Response Establishment Of Protein Localization Negative Regulation Of Innate Immune Response Regulation Of Lipid Biosynthetic Process Regulation Of Inflammatory Response Protein Stabilization Regulation Of T Cell Activation Defense Response To Virus Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Protein Complex Stability Cellular Response To Type I Interferon Cellular Response To Gamma Radiation Cellular Response To Hydroxyurea Immune Complex Formation CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway DNA Synthesis Involved In UV-damage Excision Repair Regulation Of Lysosome Organization
Pathways		Lipid particle organization	Regulation by TREX1 IRF3-mediated induction of type I IFN
Drugs
Diseases			Familial chilblain lupus (FCL); Chilblain lupus erythematosus (CHLE) Aicardi-Goutieres Syndrome (AGS) Retinal vasculopathy with cerebral leukodystrophy (RVCL)
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Bulimia nervosa ( 23568457) Cirrhosis (alcohol related) ( 32853455) Cirrhosis (multi-trait analysis) ( 33310085) Liver enzyme levels (alanine transaminase) ( 22001757) Nonalcoholic steatohepatitis ( 32298765) Platelet count ( 22139419) Rosacea symptom severity ( 29771307) Triglyceride levels ( 31928498)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Obesity-related traits ( 23251661) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		129 interacting genes: ABHD16A ADGRE2 AGPAT3 AGPAT4 AGTRAP AIG1 ANKRD46 AOC3 APOA2 ARL6IP1 ATP6V0C BBC3 BMP10 BRICD5 C3orf52 CACNG1 CALHM6 CCDC167 CDIPT CLDN10 CLDN19 CLDN4 CLDND2 CMTM5 CMTM7 CYB5R3 CYBC1 CYP4F2 DIABLO EBP ECPAS FATE1 FAXDC2 FETUB GJB2 GOLM1 GOSR2 GYPB HSD3B7 IGFBP5 INSIG2 ITGAM JAGN1 LHFPL5 LPAR3 LPCAT2 LRAT MARCHF5 MGLL MIEF2 MMP14 MOSPD3 MS4A1 NAPB NAT8 NRM ORMDL3 PBX3 PLIN3 PLN PLP2 PNLIPRP1 PTPN9 RABAC1 REEP6 RHOU RPRM RUSF1 SACM1L SCAMP5 SCARF1 SCD SEC22B SERP1 SERP2 SFT2D2 SFXN1 SFXN2 SFXN3 SLC25A46 SLC30A3 SLC35B4 SLC35E4 SLC61A1 SMIM1 SNORC SPG21 ST6GAL2 STRIT1 STX5 STX7 TBRG4 TF THSD7A TIMM23 TIMMDC1 TMEM100 TMEM120A TMEM120B TMEM128 TMEM140 TMEM14B TMEM14C TMEM167B TMEM19 TMEM203 TMEM218 TMEM222 TMEM229B TMEM243 TMEM255B TMEM31 TMEM42 TMEM60 TMEM86B TMEM97 TMX2 TPRG1 TREX1 UBXN8 UNC50 VAMP2 VAMP3 VAMP4 VAMP5 VAPA VAPB YIPF2 YIPF4	48 interacting genes: AQP6 ATM ATR CD81 CHCHD2 CLDN22 CRB3 CYB561 CYSRT1 EBP ELOVL4 ERGIC3 FAM174A FAM209A FFAR3 FNDC9 GJA5 GKN1 GPR42 HSD17B13 IFNGR2 IFT20 JAGN1 KRTAP10-7 MCM7 MSH2 NBN PEX12 PRKDC PRND RELL1 RIBC2 RNASEK RPA1 SEC11C SET SLC10A6 SLC22A2 SLC71A2 SLC7A14 TM4SF18 TMEM205 TMEM207 TMEM45B TMEM86B TMX2 UBQLN1 VKORC1
Entrez ID		345275	11277
HPRD ID		18023	09423
Ensembl ID		ENSG00000170509	ENSG00000213689
Uniprot IDs		Q7Z5P4	Q5TZT0 Q9NSU2
PDB IDs		8G9V	7TQN 7TQO 7TQP 7TQQ 8VL7 9AVA
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity Serine Import Into Mitochondrion Endomembrane System SNARE Complex Monoatomic Ion Transmembrane Transporter Activity Lipid Biosynthetic Process Organelle Fusion Mitochondrial Transport Paracellular Transport Lipid Metabolic Process Vesicle-mediated Transport Glycerolipid Metabolic Process Membrane Fusion Import Into The Mitochondrion Golgi Membrane Acylglycerol Catabolic Process Golgi Vesicle Transport Serine Transport Lysophosphatidic Acid Acyltransferase Activity SNARE Complex Assembly CDP-diacylglycerol Metabolic Process Endoplasmic Reticulum Organization Vesicle Fusion Golgi Apparatus Transport Vesicle Vesicle Organization Organelle Membrane Fusion Golgi To Plasma Membrane Protein Transport FFAT Motif Binding Mitochondrial Outer Membrane Phospholipid Metabolic Process Phospholipid Biosynthetic Process 1-acylglycerol-3-phosphate O-acyltransferase Activity Sterol Biosynthetic Process Organelle Localization By Membrane Tethering Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Acylglycerol Metabolic Process Sterol Metabolic Process Bounding Membrane Of Organelle Membrane Organization Neutral Lipid Metabolic Process Response To Endoplasmic Reticulum Stress Steroid Biosynthetic Process Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules	Histone H2AXS139 Kinase Activity Membrane Chromosome, Telomeric Region Protein Localization To Site Of Double-strand Break Double-strand Break Repair Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere DNA Strand Resection Involved In Replication Fork Processing Somatic Cell DNA Recombination Positive Regulation Of Telomerase Catalytic Core Complex Assembly Telomere Maintenance DNA Damage Checkpoint Signaling Protein Localization To Chromosome DNA-dependent Protein Kinase Activity Telomere Organization Double-strand Break Repair Via Homologous Recombination Mitotic DNA Damage Checkpoint Signaling Recombinational Repair DNA Recombination Mitotic DNA Integrity Checkpoint Signaling Signal Transduction In Response To DNA Damage Somatic Recombination Of Immunoglobulin Gene Segments Protein Binding MutLalpha Complex Binding Negative Regulation Of Telomere Capping Somatic Diversification Of Immunoglobulins Double-strand Break Repair Via Alternative Nonhomologous End Joining Negative Regulation Of Mitotic Cell Cycle Protein Localization To Organelle Chromosome Organization Negative Regulation Of Cell Cycle Phase Transition Response To Gamma Radiation Mitotic G2/M Transition Checkpoint DNA Repair Negative Regulation Of DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Telomere Capping Response To Ionizing Radiation Regulation Of Double-strand Break Repair Replicative Senescence Regulation Of Cellular Response To Heat DNA Replication Endoplasmic Reticulum Damaged DNA Binding Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of DNA-templated DNA Replication Initiation DNA Metabolic Process Negative Regulation Of Cell Cycle Process Pexophagy Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
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