HSD17B13 and LRAT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HSD17B13	LRAT
Description		hydroxysteroid 17-beta dehydrogenase 13	lecithin retinol acyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol	Cytoplasm Endosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor	Retinoic Acid Binding Protein Binding O-acyltransferase Activity O-palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Retinol Binding Phosphatidylcholine-retinol O-acyltransferase Activity
	Biological Process	Lipid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process	Retinoid Metabolic Process Lipid Metabolic Process Vitamin A Metabolic Process Visual Perception Response To Bacterium Lipid Storage Positive Regulation Of Lipid Transport Response To Retinoic Acid Response To Vitamin A Retinol Metabolic Process Cellular Response To Leukemia Inhibitory Factor
Pathways		Lipid particle organization	The canonical retinoid cycle in rods (twilight vision) Retinoid metabolism and transport Defective visual phototransduction due to LRAT loss of function
Drugs			Vitamin A
Diseases			Leber congenital amaurosis (LCR) Retinitis pigmentosa (RP)
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Bulimia nervosa ( 23568457) Cirrhosis (alcohol related) ( 32853455) Cirrhosis (multi-trait analysis) ( 33310085) Liver enzyme levels (alanine transaminase) ( 22001757) Nonalcoholic steatohepatitis ( 32298765) Platelet count ( 22139419) Rosacea symptom severity ( 29771307) Triglyceride levels ( 31928498)	Activated partial thromboplastin time ( 29403010) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		129 interacting genes: ABHD16A ADGRE2 AGPAT3 AGPAT4 AGTRAP AIG1 ANKRD46 AOC3 APOA2 ARL6IP1 ATP6V0C BBC3 BMP10 BRICD5 C3orf52 CACNG1 CALHM6 CCDC167 CDIPT CLDN10 CLDN19 CLDN4 CLDND2 CMTM5 CMTM7 CYB5R3 CYBC1 CYP4F2 DIABLO EBP ECPAS FATE1 FAXDC2 FETUB GJB2 GOLM1 GOSR2 GYPB HSD3B7 IGFBP5 INSIG2 ITGAM JAGN1 LHFPL5 LPAR3 LPCAT2 LRAT MARCHF5 MGLL MIEF2 MMP14 MOSPD3 MS4A1 NAPB NAT8 NRM ORMDL3 PBX3 PLIN3 PLN PLP2 PNLIPRP1 PTPN9 RABAC1 REEP6 RHOU RPRM RUSF1 SACM1L SCAMP5 SCARF1 SCD SEC22B SERP1 SERP2 SFT2D2 SFXN1 SFXN2 SFXN3 SLC25A46 SLC30A3 SLC35B4 SLC35E4 SLC61A1 SMIM1 SNORC SPG21 ST6GAL2 STRIT1 STX5 STX7 TBRG4 TF THSD7A TIMM23 TIMMDC1 TMEM100 TMEM120A TMEM120B TMEM128 TMEM140 TMEM14B TMEM14C TMEM167B TMEM19 TMEM203 TMEM218 TMEM222 TMEM229B TMEM243 TMEM255B TMEM31 TMEM42 TMEM60 TMEM86B TMEM97 TMX2 TPRG1 TREX1 UBXN8 UNC50 VAMP2 VAMP3 VAMP4 VAMP5 VAPA VAPB YIPF2 YIPF4	6 interacting genes: BLCAP HSD17B13 RBP1 RBP2 TMEM31 TMX2
Entrez ID		345275	9227
HPRD ID		18023	05332
Ensembl ID		ENSG00000170509	ENSG00000121207
Uniprot IDs		Q7Z5P4	O95237
PDB IDs		8G9V
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity Serine Import Into Mitochondrion Endomembrane System SNARE Complex Monoatomic Ion Transmembrane Transporter Activity Lipid Biosynthetic Process Organelle Fusion Mitochondrial Transport Paracellular Transport Lipid Metabolic Process Vesicle-mediated Transport Glycerolipid Metabolic Process Membrane Fusion Import Into The Mitochondrion Golgi Membrane Acylglycerol Catabolic Process Golgi Vesicle Transport Serine Transport Lysophosphatidic Acid Acyltransferase Activity SNARE Complex Assembly CDP-diacylglycerol Metabolic Process Endoplasmic Reticulum Organization Vesicle Fusion Golgi Apparatus Transport Vesicle Vesicle Organization Organelle Membrane Fusion Golgi To Plasma Membrane Protein Transport FFAT Motif Binding Mitochondrial Outer Membrane Phospholipid Metabolic Process Phospholipid Biosynthetic Process 1-acylglycerol-3-phosphate O-acyltransferase Activity Sterol Biosynthetic Process Organelle Localization By Membrane Tethering Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Acylglycerol Metabolic Process Sterol Metabolic Process Bounding Membrane Of Organelle Membrane Organization Neutral Lipid Metabolic Process Response To Endoplasmic Reticulum Stress Steroid Biosynthetic Process Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules	Retinal Binding Vitamin A Metabolic Process Retinoid Binding Retinol Binding Fatty Acid Binding Diterpenoid Metabolic Process Retinoid Metabolic Process Terpenoid Metabolic Process Fatty Acid Transport Lipid Droplet Isoprenoid Metabolic Process Monocarboxylic Acid Transport All-trans-retinol Binding Steroid Dehydrogenase Activity Apoptotic Nuclear Changes Retinoic Acid Biosynthetic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Carboxylic Acid Transport Organic Acid Transport Disulfide Oxidoreductase Activity Molecular Carrier Activity Lipid Metabolic Process Lipid Transport Lipid Binding Organic Anion Transport Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity All-trans-retinol Dehydrogenase (NAD+) Activity Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Isoprenoid Biosynthetic Process Retinoic Acid Metabolic Process
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