HSD17B13 and VAMP5

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		HSD17B13	VAMP5
Description		hydroxysteroid 17-beta dehydrogenase 13	vesicle associated membrane protein 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol	Late Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Cell Surface Endomembrane System Intercalated Disc Membrane Cytoplasmic Vesicle Membrane Organelle Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor	Protein Binding
	Biological Process	Lipid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process	Muscle Organ Development Skeletal Muscle Tissue Development Vesicle-mediated Transport Cell Differentiation Golgi To Plasma Membrane Protein Transport
Pathways		Lipid particle organization
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Bulimia nervosa ( 23568457) Cirrhosis (alcohol related) ( 32853455) Cirrhosis (multi-trait analysis) ( 33310085) Liver enzyme levels (alanine transaminase) ( 22001757) Nonalcoholic steatohepatitis ( 32298765) Platelet count ( 22139419) Rosacea symptom severity ( 29771307) Triglyceride levels ( 31928498)	Appendicular lean mass ( 33097823) Coronary artery disease ( 26343387 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Myocardial infarction ( 26343387) Platelet distribution width ( 32888494) Prostate cancer ( 21743467) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		129 interacting genes: ABHD16A ADGRE2 AGPAT3 AGPAT4 AGTRAP AIG1 ANKRD46 AOC3 APOA2 ARL6IP1 ATP6V0C BBC3 BMP10 BRICD5 C3orf52 CACNG1 CALHM6 CCDC167 CDIPT CLDN10 CLDN19 CLDN4 CLDND2 CMTM5 CMTM7 CYB5R3 CYBC1 CYP4F2 DIABLO EBP ECPAS FATE1 FAXDC2 FETUB GJB2 GOLM1 GOSR2 GYPB HSD3B7 IGFBP5 INSIG2 ITGAM JAGN1 LHFPL5 LPAR3 LPCAT2 LRAT MARCHF5 MGLL MIEF2 MMP14 MOSPD3 MS4A1 NAPB NAT8 NRM ORMDL3 PBX3 PLIN3 PLN PLP2 PNLIPRP1 PTPN9 RABAC1 REEP6 RHOU RPRM RUSF1 SACM1L SCAMP5 SCARF1 SCD SEC22B SERP1 SERP2 SFT2D2 SFXN1 SFXN2 SFXN3 SLC25A46 SLC30A3 SLC35B4 SLC35E4 SLC61A1 SMIM1 SNORC SPG21 ST6GAL2 STRIT1 STX5 STX7 TBRG4 TF THSD7A TIMM23 TIMMDC1 TMEM100 TMEM120A TMEM120B TMEM128 TMEM140 TMEM14B TMEM14C TMEM167B TMEM19 TMEM203 TMEM218 TMEM222 TMEM229B TMEM243 TMEM255B TMEM31 TMEM42 TMEM60 TMEM86B TMEM97 TMX2 TPRG1 TREX1 UBXN8 UNC50 VAMP2 VAMP3 VAMP4 VAMP5 VAPA VAPB YIPF2 YIPF4	57 interacting genes: ABHD16A AQP6 ARL13B ASGR2 ATP6AP2 BIK CD53 CLDN5 CLDN7 COMT CPLX4 CYB5R3 ELOVL4 ERGIC3 FAM209A FNDC9 GJA8 GORAB GPR152 GPX8 GRAMD2B HIBADH HSD17B13 IL3RA JAGN1 KIR2DL3 KIR3DL3 KLRC1 LMNA LRRC25 MDC1 MUC1 NCAPH2 PANX1 PLAC8 PVR RETREG3 SAR1A SLC14A2 SLC18A1 SPINT1 STX1A STX1B STX2 TAS2R5 TM4SF18 TMCO5A TMEM106C TMEM139 TMEM14B TMEM31 TMEM45B TMEM52B TMEM86B TMPRSS2 TMX2 VSIG4
Entrez ID		345275	10791
HPRD ID		18023	09513
Ensembl ID		ENSG00000170509	ENSG00000168899
Uniprot IDs		Q7Z5P4	O95183 Q6FG93
PDB IDs		8G9V
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity Serine Import Into Mitochondrion Endomembrane System SNARE Complex Monoatomic Ion Transmembrane Transporter Activity Lipid Biosynthetic Process Organelle Fusion Mitochondrial Transport Paracellular Transport Lipid Metabolic Process Vesicle-mediated Transport Glycerolipid Metabolic Process Membrane Fusion Import Into The Mitochondrion Golgi Membrane Acylglycerol Catabolic Process Golgi Vesicle Transport Serine Transport Lysophosphatidic Acid Acyltransferase Activity SNARE Complex Assembly CDP-diacylglycerol Metabolic Process Endoplasmic Reticulum Organization Vesicle Fusion Golgi Apparatus Transport Vesicle Vesicle Organization Organelle Membrane Fusion Golgi To Plasma Membrane Protein Transport FFAT Motif Binding Mitochondrial Outer Membrane Phospholipid Metabolic Process Phospholipid Biosynthetic Process 1-acylglycerol-3-phosphate O-acyltransferase Activity Sterol Biosynthetic Process Organelle Localization By Membrane Tethering Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Acylglycerol Metabolic Process Sterol Metabolic Process Bounding Membrane Of Organelle Membrane Organization Neutral Lipid Metabolic Process Response To Endoplasmic Reticulum Stress Steroid Biosynthetic Process Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules	Membrane Protein Binding SNARE Complex Endoplasmic Reticulum Membrane SNARE Binding Endoplasmic Reticulum Presynaptic Active Zone Membrane Synaptic Vesicle Exocytosis Monoatomic Anion Channel Activity Signal Release Norepinephrine Transport Structural Molecule Activity SNAP Receptor Activity Neurotransmitter Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Exocytosis Regulation Of Synaptic Vesicle Priming
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