HSD17B13 and ADGRE2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HSD17B13	ADGRE2
Description		hydroxysteroid 17-beta dehydrogenase 13	adhesion G protein-coupled receptor E2
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol	Plasma Membrane Membrane Leading Edge Membrane Ruffle Membrane Cell Projection
	Molecular Function	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcium Ion Binding Protein Binding Chondroitin Sulfate Binding
	Biological Process	Lipid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process	Immune System Process Inflammatory Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell Migration Regulation Of Mast Cell Degranulation Granulocyte Chemotaxis
Pathways		Lipid particle organization	Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Bulimia nervosa ( 23568457) Cirrhosis (alcohol related) ( 32853455) Cirrhosis (multi-trait analysis) ( 33310085) Liver enzyme levels (alanine transaminase) ( 22001757) Nonalcoholic steatohepatitis ( 32298765) Platelet count ( 22139419) Rosacea symptom severity ( 29771307) Triglyceride levels ( 31928498)	Blood protein levels ( 30072576) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243)
Interacting Genes		129 interacting genes: ABHD16A ADGRE2 AGPAT3 AGPAT4 AGTRAP AIG1 ANKRD46 AOC3 APOA2 ARL6IP1 ATP6V0C BBC3 BMP10 BRICD5 C3orf52 CACNG1 CALHM6 CCDC167 CDIPT CLDN10 CLDN19 CLDN4 CLDND2 CMTM5 CMTM7 CYB5R3 CYBC1 CYP4F2 DIABLO EBP ECPAS FATE1 FAXDC2 FETUB GJB2 GOLM1 GOSR2 GYPB HSD3B7 IGFBP5 INSIG2 ITGAM JAGN1 LHFPL5 LPAR3 LPCAT2 LRAT MARCHF5 MGLL MIEF2 MMP14 MOSPD3 MS4A1 NAPB NAT8 NRM ORMDL3 PBX3 PLIN3 PLN PLP2 PNLIPRP1 PTPN9 RABAC1 REEP6 RHOU RPRM RUSF1 SACM1L SCAMP5 SCARF1 SCD SEC22B SERP1 SERP2 SFT2D2 SFXN1 SFXN2 SFXN3 SLC25A46 SLC30A3 SLC35B4 SLC35E4 SLC61A1 SMIM1 SNORC SPG21 ST6GAL2 STRIT1 STX5 STX7 TBRG4 TF THSD7A TIMM23 TIMMDC1 TMEM100 TMEM120A TMEM120B TMEM128 TMEM140 TMEM14B TMEM14C TMEM167B TMEM19 TMEM203 TMEM218 TMEM222 TMEM229B TMEM243 TMEM255B TMEM31 TMEM42 TMEM60 TMEM86B TMEM97 TMX2 TPRG1 TREX1 UBXN8 UNC50 VAMP2 VAMP3 VAMP4 VAMP5 VAPA VAPB YIPF2 YIPF4	26 interacting genes: AQP6 BIK CCDC107 CD79A CREB3L1 ELOVL4 ELOVL7 ERGIC3 FAM209A FAM210B FCER1G FKBP7 GPR42 HSD17B13 KIR2DL3 LMNA MARCHF6 MMGT1 MTERF3 MTIF3 SAR1A SLC18A1 SLC61A1 SLC7A14 TLCD4 TMEM80
Entrez ID		345275	30817
HPRD ID		18023	07308
Ensembl ID		ENSG00000170509	ENSG00000127507
Uniprot IDs		Q7Z5P4	A0JNV7 B4DWB8 Q9UHX3
PDB IDs		8G9V	2BO2 2BOU 2BOX
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity Serine Import Into Mitochondrion Endomembrane System SNARE Complex Monoatomic Ion Transmembrane Transporter Activity Lipid Biosynthetic Process Organelle Fusion Mitochondrial Transport Paracellular Transport Lipid Metabolic Process Vesicle-mediated Transport Glycerolipid Metabolic Process Membrane Fusion Import Into The Mitochondrion Golgi Membrane Acylglycerol Catabolic Process Golgi Vesicle Transport Serine Transport Lysophosphatidic Acid Acyltransferase Activity SNARE Complex Assembly CDP-diacylglycerol Metabolic Process Endoplasmic Reticulum Organization Vesicle Fusion Golgi Apparatus Transport Vesicle Vesicle Organization Organelle Membrane Fusion Golgi To Plasma Membrane Protein Transport FFAT Motif Binding Mitochondrial Outer Membrane Phospholipid Metabolic Process Phospholipid Biosynthetic Process 1-acylglycerol-3-phosphate O-acyltransferase Activity Sterol Biosynthetic Process Organelle Localization By Membrane Tethering Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Acylglycerol Metabolic Process Sterol Metabolic Process Bounding Membrane Of Organelle Membrane Organization Neutral Lipid Metabolic Process Response To Endoplasmic Reticulum Stress Steroid Biosynthetic Process Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules	Endoplasmic Reticulum Membrane Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fatty Acid Elongation, Saturated Fatty Acid Endoplasmic Reticulum Membrane Serotonin Transport Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Long-chain Fatty-acyl-CoA Biosynthetic Process Long-chain Fatty-acyl-CoA Metabolic Process Fatty-acyl-CoA Biosynthetic Process
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