CR2 and C3

Number of citations of the paper that reports this interaction (PubMedID 11684127)
0

Data Source:
HPRD (in vivo, in vitro)

		CR2	C3
Description		complement C3d receptor 2	complement C3
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane Receptor Complex Extracellular Exosome	Extracellular Region Classical-complement-pathway C3/C5 Convertase Complex Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Protein-containing Complex Secretory Granule Lumen Azurophil Granule Lumen Extracellular Exosome Blood Microparticle Symbiont Cell Surface
	Molecular Function	Virus Receptor Activity Complement Binding DNA Binding Complement Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Immunoglobulin Receptor Binding Protein Homodimerization Activity	Antigen Binding Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Chemokine Activity C5L2 Anaphylatoxin Chemotactic Receptor Binding Receptor Ligand Activity
	Biological Process	Immune System Process Complement Receptor Mediated Signaling Pathway T Cell Mediated Immunity Immune Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway B Cell Differentiation B Cell Proliferation B Cell Activation Innate Immune Response Negative Regulation Of Complement Activation, Classical Pathway Symbiont Entry Into Host Cell Type I Interferon-mediated Signaling Pathway Antiviral Innate Immune Response	Positive Regulation Of Type IIa Hypersensitivity Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Positive Regulation Of Protein Phosphorylation Positive Regulation Of Activation Of Membrane Attack Complex Immune System Process Complement Receptor Mediated Signaling Pathway Lipid Metabolic Process Fatty Acid Metabolic Process Inflammatory Response Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Opsonization Response To Bacterium Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of D-glucose Transmembrane Transport Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Lipid Storage Neuron Remodeling Leukocyte Chemotaxis Killing Of Cells Of Another Organism Oviduct Epithelium Development B Cell Activation Innate Immune Response Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Phagocytosis Protein Maturation Positive Regulation Of Phagocytosis, Engulfment Amyloid-beta Clearance Complement-dependent Cytotoxicity Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Complement Activation, GZMK Pathway Positive Regulation Of Apoptotic Cell Clearance
Pathways		Regulation of Complement cascade	Alternative complement activation Activation of C3 and C5 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Peptide ligand-binding receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (i) signalling events Neutrophil degranulation Post-translational protein phosphorylation Purinergic signaling in leishmaniasis infection Regulation of Complement cascade
Drugs			Human immunoglobulin G Zinc S-Hydroxycysteine Mirococept Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form Pegcetacoplan
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Refractive error ( 32231278) Systemic sclerosis ( 29293537) Type 2 diabetes ( 21490949)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385826 20861866 21665990 23455636 20385819) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (geographic atrophy) ( 22705344) Blood protein levels ( 30072576) Complement C3 and C4 levels ( 23028341) Complement C3 levels ( 33941608) Disease progression in age-related macular degeneration ( 29346644) Early age-related macular degeneration ( 32843070) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lymphocyte count ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Triglycerides ( 24097068) White blood cell count ( 32888494)
Interacting Genes		11 interacting genes: ANXA6 C3 CD19 CR1 FCER2 FHOD1 HNRNPU IFITM1 IFNA1 NCOA1 TP53	37 interacting genes: ABL1 AGR2 ATG16L1 C2 C3AR1 C5 C5AR2 CD46 CFB CFH CFHR3 CFHR4 CFHR5 CFI CFP CPN1 CR1 CR2 CTSG EFEMP2 GC GOLGA6L9 HMGB1 HSP90AA1 ITGAM ITGAX ITGB2 KRT31 KRTAP10-8 LAMA1 LRP1 MASP1 OLFM4 PAPPA PLEKHF2 TGM2 VSIG4
Entrez ID		1380	718
HPRD ID		00399	00400
Ensembl ID		ENSG00000117322	ENSG00000125730
Uniprot IDs		P20023	B4DR57 P01024 V9HWA9
PDB IDs		1GHQ 1LY2 1W2R 1W2S 2ATY 2GSX 3OED 8SM0 8ZNI	1C3D 1GHQ 1W2S 2A73 2A74 2GOX 2I07 2ICE 2ICF 2NOJ 2QKI 2WII 2WIN 2WY7 2WY8 2XQW 2XWB 2XWJ 3D5R 3D5S 3G6J 3L3O 3L5N 3NMS 3OED 3OHX 3OXU 3RJ3 3T4A 4HW5 4HWJ 4I6O 4M76 4ONT 4ZH1 5FO7 5FO8 5FO9 5FOA 5FOB 5NBQ 5O32 5O35 6EHG 6RMT 6RMU 6RUR 6RUV 6S0B 6YO6 7AKK 7BAG 7NOZ 7PI6 7QIV 7TV9 7UE9 7ZGK 8ENU 8EOK 8HK2 8I9L 8OQ3 8OVB 8UH2 8UIN
Enriched GO Terms of Interacting Partners?		Immune Effector Process Positive Regulation Of Humoral Immune Response Positive Regulation Of Activation Of Membrane Attack Complex Regulation Of Humoral Immune Response Protein-containing Complex Positive Regulation Of Complement Activation Interferon-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Leukocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Activation Complement Receptor Mediated Signaling Pathway Complement Activation, Alternative Pathway Immune Response Immune System Process Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Immune Response-activating Signaling Pathway Lymphocyte Activation Involved In Immune Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Complement Activation Immune Response-regulating Signaling Pathway Activation Of Immune Response Leukocyte Activation Involved In Immune Response Signal Transduction Cell Activation Involved In Immune Response Negative Regulation Of Catalytic Activity Lymphocyte Activation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of ATP-dependent Activity B Cell Activation Complement Activation, Classical Pathway Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Telomere Maintenance Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Adaptive Immune Response Regulation Of Telomere Maintenance Via Telomerase Response To Other Organism Positive Regulation Of Immune Response Positive Regulation Of Immune Effector Process Innate Immune Response Complement Activation C5L2 Anaphylatoxin Chemotactic Receptor Binding Humoral Immune Response Complement Component C3b Receptor Activity Immune Complex Clearance By Erythrocytes Complement Component C4b Receptor Activity Negative Regulation Of Serine-type Endopeptidase Activity	Complement Activation Activation Of Immune Response Positive Regulation Of Immune Response Complement Activation, Alternative Pathway Immune Effector Process Complement Component C3b Binding Regulation Of Immune Response Humoral Immune Response Positive Regulation Of Immune System Process Extracellular Space Regulation Of Immune System Process Immune System Process Regulation Of Complement Activation Defense Response Response To Other Organism Response To External Biotic Stimulus Regulation Of Humoral Immune Response Immune Response Defense Response To Symbiont Defense Response To Other Organism Innate Immune Response Complement Receptor Mediated Signaling Pathway Negative Regulation Of Complement Activation Regulation Of Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Extracellular Region Complement Receptor Activity Positive Regulation Of Cell Adhesion Response To Stress Extracellular Exosome Phagocytosis Symbiont Cell Surface Regulation Of Cell Adhesion Negative Regulation Of Immune System Process Killing Of Cells Of Another Organism Complement Binding Negative Regulation Of Complement Activation, Classical Pathway Regulation Of Apoptotic Cell Clearance Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Activation Of Membrane Attack Complex Complement Activation, Lectin Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Vasculature Development Cell Killing Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Peptidase Activity Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Immune Response Serine-type Peptidase Activity
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