CR2 and IFITM1

Number of citations of the paper that reports this interaction (PubMedID 1383329)
0

Data Source:
HPRD (in vivo)

		CR2	IFITM1
Description		complement C3d receptor 2	interferon induced transmembrane protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane Receptor Complex Extracellular Exosome	Lysosome Lysosomal Membrane Golgi Apparatus Plasma Membrane Membrane Protein-containing Complex
	Molecular Function	Virus Receptor Activity Complement Binding DNA Binding Complement Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Immunoglobulin Receptor Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Immune System Process Complement Receptor Mediated Signaling Pathway T Cell Mediated Immunity Immune Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway B Cell Differentiation B Cell Proliferation B Cell Activation Innate Immune Response Negative Regulation Of Complement Activation, Classical Pathway Symbiont Entry Into Host Cell Type I Interferon-mediated Signaling Pathway Antiviral Innate Immune Response	Ossification Immune System Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Cell Migration Response To Type II Interferon Response To Interferon-alpha Response To Interferon-beta Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Osteoblast Differentiation Host-mediated Suppression Of Symbiont Invasion Defense Response To Virus Type I Interferon-mediated Signaling Pathway
Pathways		Regulation of Complement cascade	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Refractive error ( 32231278) Systemic sclerosis ( 29293537) Type 2 diabetes ( 21490949)
Interacting Genes		11 interacting genes: ANXA6 C3 CD19 CR1 FCER2 FHOD1 HNRNPU IFITM1 IFNA1 NCOA1 TP53	3 interacting genes: ABHD16A CD81 CR2
Entrez ID		1380	8519
HPRD ID		00399	05122
Ensembl ID		ENSG00000117322	ENSG00000185885
Uniprot IDs		P20023	P13164
PDB IDs		1GHQ 1LY2 1W2R 1W2S 2ATY 2GSX 3OED 8SM0 8ZNI
Enriched GO Terms of Interacting Partners?		Immune Effector Process Positive Regulation Of Humoral Immune Response Positive Regulation Of Activation Of Membrane Attack Complex Regulation Of Humoral Immune Response Protein-containing Complex Positive Regulation Of Complement Activation Interferon-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Leukocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Activation Complement Receptor Mediated Signaling Pathway Complement Activation, Alternative Pathway Immune Response Immune System Process Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Immune Response-activating Signaling Pathway Lymphocyte Activation Involved In Immune Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Complement Activation Immune Response-regulating Signaling Pathway Activation Of Immune Response Leukocyte Activation Involved In Immune Response Signal Transduction Cell Activation Involved In Immune Response Negative Regulation Of Catalytic Activity Lymphocyte Activation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of ATP-dependent Activity B Cell Activation Complement Activation, Classical Pathway Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Telomere Maintenance Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Adaptive Immune Response Regulation Of Telomere Maintenance Via Telomerase Response To Other Organism Positive Regulation Of Immune Response Positive Regulation Of Immune Effector Process Innate Immune Response Complement Activation C5L2 Anaphylatoxin Chemotactic Receptor Binding Humoral Immune Response Complement Component C3b Receptor Activity Immune Complex Clearance By Erythrocytes Complement Component C4b Receptor Activity Negative Regulation Of Serine-type Endopeptidase Activity	Macrophage Fusion Symbiont Entry Into Host Cell Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Virus Receptor Activity Lymphocyte Mediated Immunity Leukocyte Mediated Immunity Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Biological Process Involved In Interaction With Host Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Myoblast Fusion Involved In Skeletal Muscle Regeneration Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response Mitotic Spindle Astral Microtubule Humoral Immune Response MHC Class II Protein Binding Humoral Immune Response Mediated By Circulating Immunoglobulin Osteoclast Fusion Monoacylglycerol Catabolic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Complement Binding Negative Regulation Of Complement Activation, Classical Pathway Adaptive Immune Response Positive Regulation Of B Cell Receptor Signaling Pathway Complement Receptor Activity Positive Regulation Of T-helper 2 Cell Cytokine Production Tetraspanin-enriched Microdomain Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Protein Exit From Endoplasmic Reticulum Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Transferrin Receptor Binding Monoacylglycerol Lipase Activity Immunological Synapse Formation Immune Effector Process Positive Regulation Of Receptor Clustering Positive Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Complement Activation Complement Receptor Mediated Signaling Pathway Immunoglobulin Receptor Binding Complement Activation, Alternative Pathway Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Receptor Clustering Positive Regulation Of Type 2 Immune Response Phosphatidylserine Metabolic Process Positive Regulation Of T Cell Receptor Signaling Pathway Phosphatidylcholine Lysophospholipase Activity Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
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