CR2 and IFITM1

Number of citations of the paper that reports this interaction (PMID 1383329)
56

Data Source:
HPRD (in vivo)

		CR2	IFITM1
Gene Name		complement component (3d/Epstein Barr virus) receptor 2	interferon induced transmembrane protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex Extracellular Vesicular Exosome	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Complement Binding DNA Binding Complement Receptor Activity Transmembrane Signaling Receptor Activity Protein Homodimerization Activity	Receptor Signaling Protein Activity Protein Binding
	Biological Process	Complement Receptor Mediated Signaling Pathway Immune Response Complement Activation, Classical Pathway B Cell Differentiation B Cell Proliferation Innate Immune Response	Ossification Cell Surface Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Response To Virus Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Migration Response To Interferon-gamma Response To Interferon-alpha Response To Interferon-beta Intracellular Signal Transduction Negative Regulation Of Viral Genome Replication Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Viral Entry Into Host Cell Regulation Of Immune Response Defense Response To Virus Type I Interferon Signaling Pathway
Pathways			Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		Type 2 diabetes ( 21490949)
Protein-Protein Interactions		10 interactors: ANXA6 C3 CD19 CR1 FCER2 FHOD1 HNRNPU IFITM1 IFNA1 TP53	3 interactors: ABHD16A CD81 CR2
Entrez ID		1380	8519
HPRD ID		00399	05122
Ensembl ID		ENSG00000117322	ENSG00000185885
Uniprot IDs		P20023	P13164
PDB IDs		1GHQ 1LY2 1W2R 1W2S 2GSX 3OED
Enriched GO Terms of Interacting Partners?		Regulation Of Immune Response Regulation Of Humoral Immune Response Immune Response Regulation Of Immune System Process Innate Immune Response Positive Regulation Of Humoral Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Adaptive Immune Response Regulation Of Complement Activation Immune System Process Positive Regulation Of Immunoglobulin Mediated Immune Response Positive Regulation Of Immune Response Humoral Immune Response Defense Response Adaptive Immune Response T Cell Activation Involved In Immune Response Positive Regulation Of Immune System Process Regulation Of Acute Inflammatory Response Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Hydrolase Activity Positive Regulation Of Cellular Protein Metabolic Process B Cell Differentiation Negative Regulation Of Macromitophagy Negative Regulation Of Complement Activation, Alternative Pathway Oligodendrocyte Apoptotic Process Positive Regulation Of Type IIa Hypersensitivity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Lymphocyte Proliferation Mononuclear Cell Proliferation Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Protein Metabolic Process Leukocyte Proliferation Negative Regulation Of Helicase Activity Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Notch Signaling Pathway Complement Activation Signal Transduction Negative Regulation Of Complement Activation, Classical Pathway Positive Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Adaptive Immune Response Leukocyte Activation Involved In Immune Response B Cell Activation Defense Response To Virus Complement Receptor Mediated Signaling Pathway CRD-mediated MRNA Stabilization Protein Activation Cascade	Positive Regulation Of 1-phosphatidylinositol 4-kinase Activity Receptor-mediated Virion Attachment To Host Cell Complement Receptor Mediated Signaling Pathway Virion Attachment To Host Cell Adhesion Of Symbiont To Host Cell Proliferation Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of B Cell Proliferation Viral Entry Into Host Cell B Cell Proliferation Entry Into Host Cell
Tagcloud ?		abolish abrogated adenovirus agar cooperation cotransfected cotransformation cr1 deletions dramatically e1a e1b embryo encode exon foci hypertransformation immortalization immortalizing impacted oncogenes plasmid plasmids prb soft src synergistically transformation v	altogether codon downregulation enable entire envelope envg367e evade g367 gp120 hiv immunodeficiency introduces mutate overcome p24 passages replication residue restriction stop supt1 transmembrane transmission utilized viruses vpu vpu34
Tagcloud (Difference) ?		abolish abrogated adenovirus agar cooperation cotransfected cotransformation cr1 deletions dramatically e1a e1b embryo encode exon foci hypertransformation immortalization immortalizing impacted oncogenes plasmid plasmids prb soft src synergistically transformation v	altogether codon downregulation enable entire envelope envg367e evade g367 gp120 hiv immunodeficiency introduces mutate overcome p24 passages replication residue restriction stop supt1 transmembrane transmission utilized viruses vpu vpu34
Tagcloud (Intersection) ?