CR2 and FCER2

Number of citations of the paper that reports this interaction (PubMedID 8766552)
0

Data Source:
HPRD (in vitro)

		CR2	FCER2
Description		complement C3d receptor 2	Fc epsilon receptor II
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane Receptor Complex Extracellular Exosome	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Virus Receptor Activity Complement Binding DNA Binding Complement Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Immunoglobulin Receptor Binding Protein Homodimerization Activity	Protease Binding Integrin Binding Protein Binding Low-affinity IgE Receptor Activity IgE Binding Carbohydrate Binding Pattern Recognition Receptor Activity Metal Ion Binding
	Biological Process	Immune System Process Complement Receptor Mediated Signaling Pathway T Cell Mediated Immunity Immune Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway B Cell Differentiation B Cell Proliferation B Cell Activation Innate Immune Response Negative Regulation Of Complement Activation, Classical Pathway Symbiont Entry Into Host Cell Type I Interferon-mediated Signaling Pathway Antiviral Innate Immune Response	B Cell Antigen Processing And Presentation Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Immune Response Positive Regulation Of Gene Expression Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Macrophage Activation Defense Response To Bacterium Fc Receptor-mediated Immune Complex Endocytosis
Pathways		Regulation of Complement cascade	NOTCH2 intracellular domain regulates transcription Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling
Drugs			Lumiliximab
Diseases
GWAS		Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Refractive error ( 32231278) Systemic sclerosis ( 29293537) Type 2 diabetes ( 21490949)	Blood protein levels ( 30072576) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		11 interacting genes: ANXA6 C3 CD19 CR1 FCER2 FHOD1 HNRNPU IFITM1 IFNA1 NCOA1 TP53	6 interacting genes: ATF7 CR2 FYN ITGAX ITGB2 XRCC6
Entrez ID		1380	2208
HPRD ID		00399	01049
Ensembl ID		ENSG00000117322	ENSG00000104921
Uniprot IDs		P20023	K3W4U1 P06734
PDB IDs		1GHQ 1LY2 1W2R 1W2S 2ATY 2GSX 3OED 8SM0 8ZNI	1T8C 1T8D 2H2R 2H2T 4EZM 4G96 4G9A 4GI0 4GJ0 4GJX 4GK1 4GKO 4J6J 4J6K 4J6L 4J6M 4J6N 4J6P 4J6Q 4KI1 5LGK 6Y0L 6Y0M
Enriched GO Terms of Interacting Partners?		Immune Effector Process Positive Regulation Of Humoral Immune Response Positive Regulation Of Activation Of Membrane Attack Complex Regulation Of Humoral Immune Response Protein-containing Complex Positive Regulation Of Complement Activation Interferon-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Leukocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Activation Complement Receptor Mediated Signaling Pathway Complement Activation, Alternative Pathway Immune Response Immune System Process Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Immune Response-activating Signaling Pathway Lymphocyte Activation Involved In Immune Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Complement Activation Immune Response-regulating Signaling Pathway Activation Of Immune Response Leukocyte Activation Involved In Immune Response Signal Transduction Cell Activation Involved In Immune Response Negative Regulation Of Catalytic Activity Lymphocyte Activation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of ATP-dependent Activity B Cell Activation Complement Activation, Classical Pathway Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Telomere Maintenance Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Adaptive Immune Response Regulation Of Telomere Maintenance Via Telomerase Response To Other Organism Positive Regulation Of Immune Response Positive Regulation Of Immune Effector Process Innate Immune Response Complement Activation C5L2 Anaphylatoxin Chemotactic Receptor Binding Humoral Immune Response Complement Component C3b Receptor Activity Immune Complex Clearance By Erythrocytes Complement Component C4b Receptor Activity Negative Regulation Of Serine-type Endopeptidase Activity	Integrin AlphaX-beta2 Complex Positive Regulation Of Immune Response Positive Regulation Of Protein Targeting To Membrane Integrin Complex Regulation Of Protein Targeting To Membrane Heterotypic Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Vasculature Development Protein-containing Complex Binding Regulation Of Angiogenesis Ficolin-1-rich Granule Membrane Tertiary Granule Membrane Scaffold Protein Binding Activation Of Immune Response Cellular Response To Glycine Response To Singlet Oxygen Leukocyte Activation Defense Response Lymphocyte Proliferation Response To Glycine Regulation Of Multicellular Organismal Development Cell-matrix Adhesion Positive Regulation Of Endothelial Tube Morphogenesis Integrin-mediated Signaling Pathway Integrin AlphaM-beta2 Complex Integrin AlphaL-beta2 Complex Mononuclear Cell Proliferation Leukocyte Proliferation Cell Activation Response To Stress Regulation Of Immune System Process Regulation Of Protein Modification Process Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cell Shape Negative Regulation Of Hydrogen Peroxide Biosynthetic Process DNA End Binding Ku70:Ku80 Complex ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Integrin Binding Positive Regulation Of Multicellular Organismal Process Cell-substrate Adhesion CD8 Receptor Binding Type 5 Metabotropic Glutamate Receptor Binding Negative Regulation Of Dopamine Metabolic Process Immune System Process Negative Regulation Of Dendritic Spine Maintenance Growth Factor Receptor Binding Cellular Hyperosmotic Salinity Response
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