CR2 and FCER2

Number of citations of the paper that reports this interaction (PMID 7515913)
14

Data Source:
HPRD (in vitro)

		CR2	FCER2
Gene Name		complement component (3d/Epstein Barr virus) receptor 2	Fc fragment of IgE, low affinity II, receptor for (CD23)
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Gene Ontology Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Complement Binding DNA Binding Complement Receptor Activity Transmembrane Signaling Receptor Activity Protein Homodimerization Activity	Integrin Binding IgE Binding Carbohydrate Binding Metal Ion Binding
	Biological Process	Complement Receptor Mediated Signaling Pathway Immune Response Complement Activation, Classical Pathway B Cell Differentiation B Cell Proliferation Innate Immune Response	Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Notch Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Killing Of Cells Of Other Organism Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Pathways			Signaling by NOTCH2 Signaling by NOTCH NOTCH2 intracellular domain regulates transcription
Drugs
Diseases
GWAS		Type 2 diabetes ( 21490949)
Protein-Protein Interactions		10 interactors: ANXA6 C3 CD19 CR1 FCER2 FHOD1 HNRNPU IFITM1 IFNA1 TP53	5 interactors: ATF7 CR2 FYN ITGAX ITGB2
Entrez ID		1380	2208
HPRD ID		00399	01049
Ensembl ID		ENSG00000117322	ENSG00000104921
Uniprot IDs		P20023	K3W4U1 P06734
PDB IDs		1GHQ 1LY2 1W2R 1W2S 2GSX 3OED	1HLI 1KJE 1T8C 1T8D 2H2R 2H2T 4EZM 4G96 4G9A 4GI0 4GJ0 4GJX 4GK1 4GKO 4J6J 4J6K 4J6L 4J6M 4J6N 4J6P
Enriched GO Terms of Interacting Partners?		Regulation Of Immune Response Regulation Of Humoral Immune Response Immune Response Regulation Of Immune System Process Innate Immune Response Positive Regulation Of Humoral Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Adaptive Immune Response Regulation Of Complement Activation Immune System Process Positive Regulation Of Immunoglobulin Mediated Immune Response Positive Regulation Of Immune Response Humoral Immune Response Defense Response Adaptive Immune Response T Cell Activation Involved In Immune Response Positive Regulation Of Immune System Process Regulation Of Acute Inflammatory Response Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Hydrolase Activity Positive Regulation Of Cellular Protein Metabolic Process B Cell Differentiation Negative Regulation Of Macromitophagy Negative Regulation Of Complement Activation, Alternative Pathway Oligodendrocyte Apoptotic Process Positive Regulation Of Type IIa Hypersensitivity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Lymphocyte Proliferation Mononuclear Cell Proliferation Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Protein Metabolic Process Leukocyte Proliferation Negative Regulation Of Helicase Activity Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Notch Signaling Pathway Complement Activation Signal Transduction Negative Regulation Of Complement Activation, Classical Pathway Positive Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Adaptive Immune Response Leukocyte Activation Involved In Immune Response B Cell Activation Defense Response To Virus Complement Receptor Mediated Signaling Pathway CRD-mediated MRNA Stabilization Protein Activation Cascade	Lymphocyte Proliferation Mononuclear Cell Proliferation Leukocyte Proliferation Activated T Cell Proliferation Leukocyte Migration Heterotypic Cell-cell Adhesion Lymphocyte Activation Defense Response Blood Coagulation T Cell Proliferation Hemostasis Immune Response-regulating Signaling Pathway Leukocyte Activation Single Organismal Cell-cell Adhesion Regulation Of Body Fluid Levels Wound Healing Positive Regulation Of Immune Response Cell Activation Integrin-mediated Signaling Pathway Response To Wounding Cell Proliferation Immune System Process Innate Immune Response Cell Migration Regulation Of Cell Shape Regulation Of Immune Response Cell Motility Positive Regulation Of Immune System Process Complement Receptor Mediated Signaling Pathway Cell Adhesion T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Locomotion Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Response To Stress Movement Of Cell Or Subcellular Component Cellular Response To Platelet-derived Growth Factor Stimulus Extracellular Matrix Organization Extracellular Structure Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Platelet-derived Growth Factor Leukocyte Migration Involved In Inflammatory Response
Tagcloud ?		abolish abrogated adenovirus agar cooperation cotransfected cotransformation cr1 deletions dramatically e1a e1b embryo encode exon foci hypertransformation immortalization immortalizing impacted oncogenes plasmid plasmids prb soft src synergistically transformation v	adarb2 asymptomatic carriers carrying ceacam6 cntnap2 col19a1 commonest consider def4 dopaminergic draxin functionally g2019s hbg1 idiopathic initiating lrrk2 merit ncapg2 never parkinson pd pvrl2 seq slc2a14 snca tcl1b variations
Tagcloud (Difference) ?		abolish abrogated adenovirus agar cooperation cotransfected cotransformation cr1 deletions dramatically e1a e1b embryo encode exon foci hypertransformation immortalization immortalizing impacted oncogenes plasmid plasmids prb soft src synergistically transformation v	adarb2 asymptomatic carriers carrying ceacam6 cntnap2 col19a1 commonest consider def4 dopaminergic draxin functionally g2019s hbg1 idiopathic initiating lrrk2 merit ncapg2 never parkinson pd pvrl2 seq slc2a14 snca tcl1b variations
Tagcloud (Intersection) ?