CR2 and CR1

Number of citations of the paper that reports this interaction (PubMedID 7690834)
45

Data Source:
HPRD (in vivo)

		CR2	CR1
Description		complement C3d receptor 2	complement C3b/C4b receptor 1 (Knops blood group)
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane Receptor Complex Extracellular Exosome	Extracellular Space Cytoskeleton Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Plasma Membrane Raft Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Virus Receptor Activity Complement Binding DNA Binding Complement Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Immunoglobulin Receptor Binding Protein Homodimerization Activity	Virus Receptor Activity Complement Binding Complement Component C3b Binding Complement Component C4b Binding Complement Component C4b Receptor Activity Complement Receptor Activity Complement Component C3b Receptor Activity Protein Binding
	Biological Process	Immune System Process Complement Receptor Mediated Signaling Pathway T Cell Mediated Immunity Immune Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway B Cell Differentiation B Cell Proliferation B Cell Activation Innate Immune Response Negative Regulation Of Complement Activation, Classical Pathway Symbiont Entry Into Host Cell Type I Interferon-mediated Signaling Pathway Antiviral Innate Immune Response	Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Activation Of Membrane Attack Complex Immune System Process Complement Receptor Mediated Signaling Pathway Immune Complex Clearance By Erythrocytes T Cell Mediated Immunity Negative Regulation Of Immunoglobulin Production Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Plasma Membrane Organization Positive Regulation Of Cell Population Proliferation Regulation Of Complement Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Complement Activation Negative Regulation Of Complement Activation, Alternative Pathway Negative Regulation Of Complement Activation, Classical Pathway Symbiont Entry Into Host Cell Negative Regulation Of Serine-type Endopeptidase Activity Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Plasma Cell Differentiation Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Complement-dependent Cytotoxicity ATP Export
Pathways		Regulation of Complement cascade	Neutrophil degranulation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Regulation of Complement cascade
Drugs
Diseases
GWAS		Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Refractive error ( 32231278) Systemic sclerosis ( 29293537) Type 2 diabetes ( 21490949)	Alzheimer's disease ( 21460840 31473137 19734903) Alzheimer's disease (late onset) ( 28714976 30617256 24162737 21460841) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Erythrocyte sedimentation rate ( 21700265) Family history of Alzheimer's disease ( 30617256) Inflammatory biomarkers ( 22291609) Metabolite levels ( 23823483) Refractive error ( 32231278) Systemic sclerosis ( 29293537)
Interacting Genes		11 interacting genes: ANXA6 C3 CD19 CR1 FCER2 FHOD1 HNRNPU IFITM1 IFNA1 NCOA1 TP53	6 interacting genes: C1QA C3 C4A CD55 CR2 FUT4
Entrez ID		1380	1378
HPRD ID		00399	00398
Ensembl ID		ENSG00000117322	ENSG00000203710
Uniprot IDs		P20023	E9PDY4 P17927
PDB IDs		1GHQ 1LY2 1W2R 1W2S 2ATY 2GSX 3OED 8SM0 8ZNI	1GKG 1GKN 1PPQ 2MCY 2MCZ 2Q7Z 5FO9
Enriched GO Terms of Interacting Partners?		Immune Effector Process Positive Regulation Of Humoral Immune Response Positive Regulation Of Activation Of Membrane Attack Complex Regulation Of Humoral Immune Response Protein-containing Complex Positive Regulation Of Complement Activation Interferon-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Leukocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Activation Complement Receptor Mediated Signaling Pathway Complement Activation, Alternative Pathway Immune Response Immune System Process Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Immune Response-activating Signaling Pathway Lymphocyte Activation Involved In Immune Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Complement Activation Immune Response-regulating Signaling Pathway Activation Of Immune Response Leukocyte Activation Involved In Immune Response Signal Transduction Cell Activation Involved In Immune Response Negative Regulation Of Catalytic Activity Lymphocyte Activation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of ATP-dependent Activity B Cell Activation Complement Activation, Classical Pathway Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Telomere Maintenance Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Adaptive Immune Response Regulation Of Telomere Maintenance Via Telomerase Response To Other Organism Positive Regulation Of Immune Response Positive Regulation Of Immune Effector Process Innate Immune Response Complement Activation C5L2 Anaphylatoxin Chemotactic Receptor Binding Humoral Immune Response Complement Component C3b Receptor Activity Immune Complex Clearance By Erythrocytes Complement Component C4b Receptor Activity Negative Regulation Of Serine-type Endopeptidase Activity	Complement Activation, Classical Pathway Complement Activation Humoral Immune Response Symbiont Cell Surface Positive Regulation Of Immune System Process Immune Effector Process Regulation Of Complement Activation Activation Of Immune Response Defense Response Vertebrate Eye-specific Patterning Classical-complement-pathway C3/C5 Convertase Complex Cell Surface Innate Immune Response Regulation Of Humoral Immune Response Positive Regulation Of Immune Response Complement-mediated Synapse Pruning Regulation Of Immune System Process Defense Response To Symbiont Defense Response To Other Organism Immune System Process Complement Binding Positive Regulation Of Apoptotic Cell Clearance Regulation Of Immune Response Synapse Pruning Regulation Of Apoptotic Cell Clearance Response To Other Organism Complement Activation, Lectin Pathway Complement Activation, GZMK Pathway Activation Of Membrane Attack Complex Neuron Remodeling Immune Response Complement Receptor Mediated Signaling Pathway Negative Regulation Of Complement Activation Complement Activation, Alternative Pathway Opsonization Response To External Biotic Stimulus Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Response To Stress Regulation Of Adaptive Immune Response Neuron Maturation Antigen Binding Endopeptidase Inhibitor Activity Positive Regulation Of Phagocytosis Virus Receptor Activity C5L2 Anaphylatoxin Chemotactic Receptor Binding Regulation Of Phagocytosis Inflammatory Response Leukocyte Activation Positive Regulation Of Activation Of Membrane Attack Complex
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