IFIT1 and IFIT2

Number of citations of the paper that reports this interaction (PMID 21642987)
66

Data Source:
BioGRID (pull down)

		IFIT1	IFIT2
Gene Name		interferon-induced protein with tetratricopeptide repeats 1	interferon-induced protein with tetratricopeptide repeats 2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Endoplasmic Reticulum Cytosol
	Molecular Function	RNA Binding Protein Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Response To Virus Intracellular Transport Of Viral Protein In Host Cell Cytokine-mediated Signaling Pathway Negative Regulation Of Protein Binding Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Negative Regulation Of Defense Response To Virus By Host Negative Regulation Of Helicase Activity Defense Response To Virus Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Cellular Response To Exogenous DsRNA	Apoptotic Mitochondrial Changes Response To Virus Cytokine-mediated Signaling Pathway Negative Regulation Of Protein Binding Cellular Response To Interferon-alpha Positive Regulation Of Apoptotic Process Defense Response To Virus Type I Interferon Signaling Pathway
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling Antiviral mechanism by IFN-stimulated genes	Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: EIF3E IFIT2 IFIT3 IFIT5	3 interactors: IFIT1 IFIT3 NUTM1
Entrez ID		3434	3433
HPRD ID		00983	00913
Ensembl ID			ENSG00000119922
Uniprot IDs		D3DR31 P09914	P09913 Q05DN2
PDB IDs		4HOU	4G1T
Enriched GO Terms of Interacting Partners?		Cellular Response To Interferon-alpha Defense Response To Virus Response To Interferon-alpha Response To Virus Response To Other Organism Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Biotic Stimulus Response To Type I Interferon Innate Immune Response Immune Response Defense Response Response To External Stimulus Cytokine-mediated Signaling Pathway Immune System Process Negative Regulation Of Translational Initiation Formation Of Translation Preinitiation Complex Cellular Response To Cytokine Stimulus Response To Cytokine Negative Regulation Of Protein Binding Response To Stress	Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Defense Response To Virus Response To Virus Negative Regulation Of Helicase Activity Cytokine-mediated Signaling Pathway Intracellular Transport Of Viral Protein In Host Cell Cellular Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Cellular Response To Interferon-alpha Negative Regulation Of Defense Response To Virus By Host Response To Cytokine Response To Other Organism Response To Biotic Stimulus Innate Immune Response Response To Interferon-alpha Positive Regulation Of Viral Genome Replication Negative Regulation Of Defense Response To Virus Intracellular Transport Of Virus Regulation Of Defense Response To Virus By Host Immune Response Cellular Response To DsRNA Defense Response Negative Regulation Of Viral Genome Replication Response To Exogenous DsRNA Negative Regulation Of Protein Binding Regulation Of Viral Genome Replication Response To External Stimulus Positive Regulation Of Viral Process Response To DsRNA Negative Regulation Of Viral Process Cellular Response To Organic Substance Regulation Of Defense Response To Virus Negative Regulation Of Binding Immune System Process Interaction With Host Response To Organic Substance Regulation Of Protein Binding Regulation Of Viral Process Viral Life Cycle Cell Surface Receptor Signaling Pathway Response To Stress Regulation Of Binding Negative Regulation Of Immune System Process
Tagcloud ?		activates becomes canonical confers constitutive constitutively dissociates egfr epidermal erk exclusive glioblastoma ifi27 irf3 leading mechanistically modes mutually oncogenic oscillates overexpressed regular shc signalling signals switch switches tbk1 trail	adenovirus apobec3a ddx58 exact expand hiv ifi27 ifi44l ifit1 ifit3 innate irf7 isg15 isg20 isgs mdms microarray monocyte mx1 mx2 reservoirs rig rsad2 select stat1 tnfsf10 trail viperin vpr
Tagcloud (Difference) ?		activates becomes canonical confers constitutive constitutively dissociates egfr epidermal erk exclusive glioblastoma irf3 leading mechanistically modes mutually oncogenic oscillates overexpressed regular shc signalling signals switch switches tbk1	adenovirus apobec3a ddx58 exact expand hiv ifi44l ifit3 innate irf7 isg15 isg20 isgs mdms microarray monocyte mx1 mx2 reservoirs rig rsad2 select stat1 tnfsf10 viperin vpr
Tagcloud (Intersection) ?		ifi27 ifit1 trail