IFIT1 and EIF3E

Number of citations of the paper that reports this interaction (PMID 11118224)
58

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		IFIT1	EIF3E
Gene Name		interferon-induced protein with tetratricopeptide repeats 1	eukaryotic translation initiation factor 3, subunit E
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex PML Body Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome
	Molecular Function	RNA Binding Protein Binding	Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding Protein N-terminus Binding
	Biological Process	Response To Virus Intracellular Transport Of Viral Protein In Host Cell Cytokine-mediated Signaling Pathway Negative Regulation Of Protein Binding Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Negative Regulation Of Defense Response To Virus By Host Negative Regulation Of Helicase Activity Defense Response To Virus Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Cellular Response To Exogenous DsRNA	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process Negative Regulation Of Translational Initiation
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling Antiviral mechanism by IFN-stimulated genes	Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS			Dupuytren's disease ( 21732829)
Protein-Protein Interactions		4 interactors: EIF3E IFIT2 IFIT3 IFIT5	25 interactors: ATM C4orf19 COPS6 COPS7A COPS7B COPS8 DDX24 EIF3C EIF3L EIF4ENIF1 EPAS1 GPAA1 GPBP1L1 HAP1 IFIT1 NDRG1 NPM1 NSF PRRC2A RUNDC3A SHBG SMAD9 TRIM27 TRIM55 TRIM63
Entrez ID		3434	3646
HPRD ID		00983	03734
Ensembl ID			ENSG00000104408
Uniprot IDs		D3DR31 P09914	B3KW56 P60228
PDB IDs		4HOU
Enriched GO Terms of Interacting Partners?		Cellular Response To Interferon-alpha Defense Response To Virus Response To Interferon-alpha Response To Virus Response To Other Organism Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Biotic Stimulus Response To Type I Interferon Innate Immune Response Immune Response Defense Response Response To External Stimulus Cytokine-mediated Signaling Pathway Immune System Process Negative Regulation Of Translational Initiation Formation Of Translation Preinitiation Complex Cellular Response To Cytokine Stimulus Response To Cytokine Negative Regulation Of Protein Binding Response To Stress	Cullin Deneddylation Protein Deneddylation Protein Modification By Small Protein Removal Cellular Response To Organic Cyclic Compound Response To Hypoxia Formation Of Translation Preinitiation Complex Ribonucleoprotein Complex Assembly Cellular Response To DsRNA Signaling Cell Communication Posttranscriptional Regulation Of Gene Expression Cellular Protein Metabolic Process Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Positive Regulation Of Neurotrophin Production Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Positive Regulation Of Nonmotile Primary Cilium Assembly Primary Spermatocyte Growth Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Process Response To Organic Cyclic Compound Signal Transduction Protein Localization Protein Transport Cellular Protein Modification Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Response To DNA Damage Stimulus Cell Aging Negative Regulation Of Interleukin-2 Secretion Golgi Vesicle Docking Establishment Of Protein Localization Regulation Of Translational Initiation Regulation Of Translation Telomere Maintenance Response To DsRNA Positive Regulation Of Cell Cycle Negative Regulation Of Viral Process DNA Damage Response, Signal Transduction By P53 Class Mediator Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Cilium Assembly Regulation Of Ribonuclease Activity Negative Regulation Of Helicase Activity Regulation Of Endodeoxyribonuclease Activity Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Metabolic Process Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Aging
Tagcloud ?		activates becomes canonical confers constitutive constitutively dissociates egfr epidermal erk exclusive glioblastoma ifi27 irf3 leading mechanistically modes mutually oncogenic oscillates overexpressed regular shc signalling signals switch switches tbk1 trail	adjacent classification clonality colon contained distant elucidated eukaryotic histopathologic initiation invasion involvement lymph mammalian metastasis microarray mucosa multivariate node paired predict prognosis promoted significance tma translation translational univariate vessel
Tagcloud (Difference) ?		activates becomes canonical confers constitutive constitutively dissociates egfr epidermal erk exclusive glioblastoma ifi27 irf3 leading mechanistically modes mutually oncogenic oscillates overexpressed regular shc signalling signals switch switches tbk1 trail	adjacent classification clonality colon contained distant elucidated eukaryotic histopathologic initiation invasion involvement lymph mammalian metastasis microarray mucosa multivariate node paired predict prognosis promoted significance tma translation translational univariate vessel
Tagcloud (Intersection) ?