IDH3B and ATXN2

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		IDH3B	ATXN2
Gene Name		isocitrate dehydrogenase 3 (NAD+) beta	ataxin 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix	Nucleoplasm Cytoplasm Golgi Apparatus Trans-Golgi Network Polysome Cytoplasmic Stress Granule Membrane Ribonucleoprotein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Magnesium Ion Binding Isocitrate Dehydrogenase (NAD+) Activity Electron Carrier Activity NAD Binding	RNA Binding Epidermal Growth Factor Receptor Binding Protein Binding Protein C-terminus Binding Poly(A) RNA Binding
	Biological Process	Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process NADH Metabolic Process Cellular Metabolic Process Small Molecule Metabolic Process	Negative Regulation Of Receptor Internalization Regulation Of Translation RNA Metabolic Process Cerebellar Purkinje Cell Differentiation Cytoplasmic MRNA Processing Body Assembly Stress Granule Assembly Negative Regulation Of Multicellular Organism Growth Neuron Projection Morphogenesis Homeostasis Of Number Of Cells RNA Transport Neuromuscular Process
Pathways		Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Citric acid cycle (TCA cycle)
Drugs		NADH
Diseases
GWAS			Beta-2 microglubulin plasma levels ( 23417110) Blood pressure ( 21909110) Celiac disease ( 18311140) Chronic kidney disease ( 20383146) Diastolic blood pressure ( 19430483) Hematocrit ( 19862010) Hypothyroidism ( 22493691) Red blood cell traits ( 23222517) Retinal vascular caliber ( 21060863) Urate levels ( 23263486)
Protein-Protein Interactions		6 interactors: ATXN2 IDH3A IDH3G MAPK6 PRMT1 RAB35	19 interactors: ACTN1 ACTN2 ATXN1 BAG6 BIN1 CHGB GFI1B GOLGA6L5P IDH3B KIAA1279 LCP1 NCOA4 PABPC1 PLS3 RBFOX1 SH3GL2 SH3GL3 TDRD7 ZNRD1
Entrez ID		3420	6311
HPRD ID		05163	03307
Ensembl ID		ENSG00000101365	ENSG00000204842
Uniprot IDs		O43837	Q99700
PDB IDs			3KTR
Enriched GO Terms of Interacting Partners?		Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Aerobic Respiration Cellular Respiration Neuron Projection Development Negative Regulation Of Megakaryocyte Differentiation Neuron Development Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Plasma Membrane To Endosome Transport Neuron Differentiation Cell Projection Organization Isocitrate Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Protein Localization To Endosome Negative Regulation Of Receptor Internalization Cytoplasmic MRNA Processing Body Assembly Peptidyl-arginine N-methylation Histone H4-R3 Methylation Cerebellar Purkinje Cell Differentiation Stress Granule Assembly Cerebellar Purkinje Cell Layer Morphogenesis Generation Of Precursor Metabolites And Energy Histone Arginine Methylation Peptidyl-arginine Methylation Regulation Of Megakaryocyte Differentiation Generation Of Neurons Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Multicellular Organism Growth Neurogenesis Endocytic Recycling Cerebellar Cortex Formation Cellular Response To Nerve Growth Factor Stimulus Cell Development Cell Differentiation In Hindbrain Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Receptor Internalization Cerebellar Purkinje Cell Layer Development Cerebellar Cortex Morphogenesis	System Development Multicellular Organismal Development Anatomical Structure Development Focal Adhesion Assembly Developmental Process Adherens Junction Assembly Cell-substrate Junction Assembly Actin Filament Bundle Assembly Regulation Of Metabolic Process Platelet Degranulation Lipid Tube Assembly Adherens Junction Organization
Tagcloud ?			accumulations als amyotrophic basophilic c9orf72 causative cohorts colocalization cord expansion expansions fused ggggcc granules hexanucleotide highlights inclusions indicative motor neuron pabp paralysis polyglutamine proteomic repeat sarcoma spinal tdp transactive
Tagcloud (Difference) ?			accumulations als amyotrophic basophilic c9orf72 causative cohorts colocalization cord expansion expansions fused ggggcc granules hexanucleotide highlights inclusions indicative motor neuron pabp paralysis polyglutamine proteomic repeat sarcoma spinal tdp transactive
Tagcloud (Intersection) ?