IDH3B and IDH3G

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, genetic interference, biochemical, biochemical)
HPRD (in vivo)

		IDH3B	IDH3G
Description		isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta	isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma
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GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Isocitrate Dehydrogenase Complex (NAD+)	Nucleolus Mitochondrion Mitochondrial Matrix Isocitrate Dehydrogenase Complex (NAD+)
	Molecular Function	Magnesium Ion Binding Isocitrate Dehydrogenase (NAD+) Activity Protein Binding Electron Transfer Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor NAD Binding	Nucleotide Binding Magnesium Ion Binding Isocitrate Dehydrogenase (NAD+) Activity Protein Binding ATP Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Metal Ion Binding NAD Binding
	Biological Process	Tricarboxylic Acid Cycle Isocitrate Metabolic Process	Carbohydrate Metabolic Process Tricarboxylic Acid Cycle Isocitrate Metabolic Process
Pathways		Citric acid cycle (TCA cycle)	Mitochondrial protein import Citric acid cycle (TCA cycle)
Drugs		NADH	NADH Manganese
Diseases		Retinitis pigmentosa (RP)
GWAS
Interacting Genes		6 interacting genes: ATXN2 IDH3A IDH3G MAPK6 PRMT1 RAB35	3 interacting genes: ERCC6 IDH3A IDH3B
Entrez ID		3420	3421
HPRD ID		05163	02100
Ensembl ID		ENSG00000101365	ENSG00000067829
Uniprot IDs		A0A087WZN1 A0A087X2E5 O43837	O15384 P51553
PDB IDs		6KDE 6KDF 6KDY 6KE3 7CE3 8GRB 8GRD 8GRU 8GS5	5GRE 5GRF 5GRH 5GRI 5GRL 5YVT 6L57 6L59 7CE3 8GRG 8GRH 8GS5
Enriched GO Terms of Interacting Partners?		Isocitrate Dehydrogenase (NAD+) Activity Isocitrate Dehydrogenase Complex (NAD+) Isocitrate Metabolic Process Tricarboxylic Acid Metabolic Process Tricarboxylic Acid Cycle NAD Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor GATOR1 Complex Binding Septin Cytoskeleton Protein-arginine Omega-N Monomethyltransferase Activity N-methyltransferase Activity Histone H4R3 Methyltransferase Activity Positive Regulation Of Hemoglobin Biosynthetic Process Peptidyl-arginine Methylation Regulation Of Hemoglobin Biosynthetic Process Mitogen-activated Protein Kinase P38 Binding Response To Methionine Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone H4 Methyltransferase Activity Cellular Response To Methionine Magnesium Ion Binding	Isocitrate Dehydrogenase (NAD+) Activity Isocitrate Dehydrogenase Complex (NAD+) Isocitrate Metabolic Process Tricarboxylic Acid Metabolic Process Tricarboxylic Acid Cycle NAD Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Magnesium Ion Binding Alcohol Metabolic Process DNA Protection Transcription Elongation By RNA Polymerase I Response To Superoxide Response To Oxygen Radical B-WICH Complex Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Pyrimidine Dimer Repair Mitochondrial Matrix Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Transcription By RNA Polymerase III ATP-dependent Chromatin Remodeler Activity RNA Polymerase Binding ATP-dependent DNA Damage Sensor Activity Protein Tyrosine Kinase Activator Activity Chromatin-protein Adaptor Activity Transcription Elongation Factor Complex Positive Regulation Of Peptidyl-serine Phosphorylation Response To UV-B Regulation Of Peptidyl-serine Phosphorylation Regulation Of Transcription By RNA Polymerase III Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Transcription By RNA Polymerase I Response To X-ray ATP-dependent Activity, Acting On DNA Organic Acid Metabolic Process Carboxylic Acid Metabolic Process Positive Regulation Of Defense Response To Virus By Host Base-excision Repair DNA Helicase Activity Negative Regulation Of DNA Repair Site Of DNA Damage Photoreceptor Cell Maintenance Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Double-strand Break Repair Regulation Of Defense Response To Virus By Host Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Nucleotide-excision Repair Response To Gamma Radiation
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