ID4 and HES1

Number of citations of the paper that reports this interaction (PMID 11756408)
23

Data Source:
HPRD (two hybrid)

		ID4	HES1
Gene Name		inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	hes family bHLH transcription factor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Factor Binding Transcription Corepressor Activity Protein Binding Protein Dimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Chaperone Binding N-box Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Neuroblast Proliferation Circadian Rhythm Positive Regulation Of Cell Proliferation Hippocampus Development Cerebral Cortex Neuron Differentiation Central Nervous System Myelination Cellular Protein Localization Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Liver Development Embryonic Heart Tube Morphogenesis Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Ventricular Septum Development Transcription From RNA Polymerase II Promoter Protein Complex Assembly Cell Adhesion Notch Signaling Pathway Smoothened Signaling Pathway STAT Protein Import Into Nucleus Nervous System Development Positive Regulation Of Cell Proliferation Cell Migration Telencephalon Development Midbrain-hindbrain Boundary Morphogenesis Oculomotor Nerve Development Trochlear Nerve Development Hindbrain Morphogenesis Forebrain Radial Glial Cell Differentiation Adenohypophysis Development Lung Development Positive Regulation Of BMP Signaling Pathway Midbrain Development Endocrine Pancreas Development Somatic Stem Cell Maintenance Ascending Aorta Morphogenesis Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Auditory Receptor Cell Fate Determination Positive Regulation Of DNA Binding Regulation Of Fat Cell Differentiation Negative Regulation Of Auditory Receptor Cell Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Mitotic Cell Cycle, Embryonic Lateral Inhibition Positive Regulation Of JAK-STAT Cascade Cell Maturation Thymus Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Artery Morphogenesis Regulation Of Timing Of Neuron Differentiation Negative Regulation Of Glial Cell Proliferation Ventricular Septum Morphogenesis Ureteric Bud Morphogenesis Labyrinthine Layer Blood Vessel Development Common Bile Duct Development Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Pharyngeal Arch Artery Morphogenesis Glomerulus Vasculature Development Comma-shaped Body Morphogenesis S-shaped Body Morphogenesis Renal Interstitial Fibroblast Development Metanephric Nephron Tubule Morphogenesis Cochlea Development Vascular Smooth Muscle Cell Development Neuronal Stem Cell Maintenance Negative Regulation Of Pancreatic A Cell Differentiation Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Forebrain Neuron Differentiation
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 intracellular domain regulates transcription Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH2 Regulation of beta-cell development Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Endometriosis ( 23472165) Height ( 20881960) Response to statin therapy ( 20339536)
Protein-Protein Interactions		4 interactors: HES1 ID3 MYOD1 TCF4	33 interactors: APCS APH1A ASGR2 CSNK1E FANCA FANCE FANCF FANCG FANCL FHL1 FOXG1 GAPDH HDAC6 HES6 HEY2 HMGB1 HMGCL ID1 ID2 ID3 ID4 JAK2 LTBR NR4A1 NUDT3 PRKCA PTK2 SIRT1 STAT3 TLE1 TLE2 UBQLN1 YWHAB
Entrez ID		3400	3280
HPRD ID		08995	00770
Ensembl ID			ENSG00000114315
Uniprot IDs		P47928	Q14469
PDB IDs
Enriched GO Terms of Interacting Partners?		Muscle Structure Development Myoblast Fate Commitment Cell Fate Commitment Muscle Cell Differentiation Regulation Of Myoblast Differentiation Regulation Of Cell Differentiation Regulation Of Oligodendrocyte Differentiation Myoblast Differentiation Cell Fate Determination Tissue Development Pituitary Gland Development Embryonic Organ Development Positive Regulation Of Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Skeletal Muscle Tissue Development Somatic Stem Cell Maintenance Regulation Of Glial Cell Differentiation Regulation Of BMP Signaling Pathway Diencephalon Development Transcription, DNA-templated Pancreas Development RNA Biosynthetic Process Regulation Of Gliogenesis Negative Regulation Of Cell Differentiation Metanephros Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Binding Protein Import Into Nucleus Nuclear Import Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Pharyngeal Arch Artery Morphogenesis Lateral Inhibition Regulation Of Fat Cell Differentiation Regulation Of Cell Development Positive Regulation Of Cell Differentiation Odontogenesis Transcription From RNA Polymerase II Promoter Regulation Of Striated Muscle Tissue Development Cardiovascular System Development Cellular Response To Starvation Regulation Of Cell Cycle Stem Cell Maintenance Regulation Of Muscle Cell Differentiation Protein Import Organ Development Central Nervous System Development Organ Morphogenesis Protein Localization To Nucleus	System Development Organ Development Multicellular Organismal Development Response To Stress Anatomical Structure Development Regulation Of Cell Death Negative Regulation Of Biosynthetic Process Developmental Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Response To Stimulus Rhythmic Process Cellular Metabolic Process Cellular Response To Stimulus Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Differentiation Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Nitrogen Compound Metabolic Process Circadian Rhythm Regulation Of DNA Binding Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Cellular Response To Stress Negative Regulation Of Cell Differentiation Apoptotic Process Negative Regulation Of DNA Binding Regulation Of Cell Differentiation Programmed Cell Death Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Death Death Regulation Of Osteoblast Differentiation Positive Regulation Of Apoptotic Process DNA Repair Response To Growth Factor Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Negative Regulation Of Cell Death
Tagcloud ?		9a8 bodies concluded confined diffuse excess fixed frozen gn gs hcp hpi ica igg1 igg2a immunofluorescent indirect intense islet islets mab pancreas proinsulin radiating reacting sections staining treadlike visualized	alterations anatomic astrocytoma astrocytomas biology braf grade hey1 hey2 implicated inhibiting interference much needed neoplastic notch notch1 notch2 overexpressed pa pas pediatric pilocytic res186 res259 secretase tumorigenesis variable viable
Tagcloud (Difference) ?		9a8 bodies concluded confined diffuse excess fixed frozen gn gs hcp hpi ica igg1 igg2a immunofluorescent indirect intense islet islets mab pancreas proinsulin radiating reacting sections staining treadlike visualized	alterations anatomic astrocytoma astrocytomas biology braf grade hey1 hey2 implicated inhibiting interference much needed neoplastic notch notch1 notch2 overexpressed pa pas pediatric pilocytic res186 res259 secretase tumorigenesis variable viable
Tagcloud (Intersection) ?