ID4 and ID3

Number of citations: 70 (PubMedID 8759016)
Data Source: HPRD (in vivo, two hybrid)

		ID4	ID3
Name		inhibitor of DNA binding 4	inhibitor of DNA binding 3
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Corepressor Activity Protein Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity	Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Protein Dimerization Activity Transcription Regulator Inhibitor Activity Leptomycin B Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Positive Regulation Of Neuroblast Proliferation Neuroblast Proliferation Brain Development Circadian Rhythm Intracellular Protein Localization Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Hippocampus Development Cerebral Cortex Neuron Differentiation Central Nervous System Neuron Differentiation Central Nervous System Myelination Neuron Differentiation Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Astrocyte Differentiation Oligodendrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Prostate Gland Morphogenesis Prostate Gland Epithelium Morphogenesis Prostate Gland Stromal Morphogenesis Seminal Vesicle Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Regulation Of DNA Replication Central Nervous System Development Heart Development Muscle Organ Development Circadian Rhythm Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Neuron Differentiation Epithelial Cell Differentiation Notochord Development Odontogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Myoblast Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Leptomycin B
Pathways		NGF-stimulated transcription Formation of the nephric duct	NGF-stimulated transcription
GWAS		Age at first birth ( 34211149 ) Age at voice drop ( 27182965 ) Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325 ) Anthropometric traits ( 30166351 ) Anthropometric traits (multi-trait analysis) ( 30166351 ) Appendicular lean mass ( 33097823 ) Automobile speeding propensity ( 30643258 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Chronic obstructive pulmonary disease ( 30804561 ) Chronotype ( 30696823 ) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195 ) Endometriosis ( 23472165 28333195 28537267 ) Free thyroxine concentration ( 30367059 ) Height ( 28552196 20881960 ) Hip circumference adjusted for BMI ( 34021172 ) Loneliness (multivariate analysis) ( 27629369 ) Response to statin therapy ( 20339536 ) Waist circumference adjusted for body mass index ( 34021172 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: GRIN2A	1 novel interactors: CEP350
Interacting Genes		4 interacting genes: HES1 ID3 MYOD1 TCF4	49 interacting genes: ADD1 ANKS1A ATF3 BOLA2 BOLA2B C22orf39 CBFA2T2 CDK2 CNOT3 CREB5 CSK E2F4 ELK1 ELK4 FAM74A1 FHL2 FRS3 GATA4 GNB2 GTF2A1L GUCD1 HES1 HOXA1 ID4 IFI16 IKBKG KAT5 KRTAP26-1 LMO4 MLX MSGN1 MYF5 MYF6 MYOD1 MYOG PAX5 PRDM14 PUF60 RND1 RUNX1T1 SAP30 SDCBP SREBF1 TCF12 TCF3 TCF4 ZNF3 ZNF408 ZNF626
Entrez ID		3400	3399
HPRD ID		08995	02608
Ensembl ID		ENSG00000172201	ENSG00000117318
Uniprot IDs		P47928	Q02535
PDB IDs		Not available	2LFH
GO Terms Enriched among Interactors		Protein Dimerization Activity E-box Binding Cell Differentiation Cellular Response To Oxygen-containing Compound Cell Fate Determination Cellular Response To Fatty Acid BHLH Transcription Factor Binding Cellular Developmental Process Animal Organ Development Regulation Of Cell Differentiation Muscle Cell Development Negative Regulation Of Pancreatic A Cell Differentiation N-box Binding Negative Regulation Of Cell Fate Determination Positive Regulation Of Mitotic Cell Cycle, Embryonic Cellular Response To Lipid Trochlear Nerve Development Response To Fatty Acid Cellular Response To Tumor Necrosis Factor Cellular Response To Leptomycin B Regulation Of Myoblast Differentiation Leptomycin B Binding Sequence-specific Double-stranded DNA Binding Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Oculomotor Nerve Development Cajal-Retzius Cell Differentiation Negative Regulation Of Forebrain Neuron Differentiation Response To Tumor Necrosis Factor Hindbrain Morphogenesis Renal Interstitial Fibroblast Development Muscle Organ Development Myoblast Fate Determination Directional Locomotion Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Regulation Of Timing Of Neuron Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Ureteric Bud Morphogenesis Negative Regulation Of Lymphoid Progenitor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Amacrine Cell Differentiation Embryonic Organ Development Negative Regulation Of Pro-B Cell Differentiation Cell Fate Commitment Regulation Of Mitotic Cell Cycle, Embryonic HLH Domain Binding Metanephric Nephron Tubule Morphogenesis Midbrain-hindbrain Boundary Morphogenesis Stomach Neuroendocrine Cell Differentiation Response To Aroclor 1254 Regulation Of Forebrain Neuron Differentiation	Protein Dimerization Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II DNA Binding Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding E-box Binding Chromatin RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Cellular Developmental Process Nucleus Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Cell Differentiation Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Skeletal Muscle Cell Differentiation Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Skeletal Muscle Fiber Development Regulation Of Skeletal Muscle Fiber Development Nucleoplasm Positive Regulation Of Metabolic Process Transcription Regulator Complex Cell Fate Commitment Negative Regulation Of Macromolecule Biosynthetic Process Muscle Cell Fate Commitment Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Biosynthetic Process Positive Regulation Of Myoblast Differentiation Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Striated Muscle Tissue Development