RAMP1 and VIPR1

Number of citations of the paper that reports this interaction (PubMedID 12446722)
0

Data Source:
HPRD (in vitro)

		RAMP1	VIPR1
Description		receptor activity modifying protein 1	vasoactive intestinal peptide receptor 1
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Receptor Complex CGRP Receptor Complex	Plasma Membrane Membrane Receptor Complex
	Molecular Function	Calcitonin Gene-related Peptide Receptor Activity Protein Binding Coreceptor Activity Amylin Receptor Activity Calcitonin Gene-related Peptide Binding	Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Vasoactive Intestinal Polypeptide Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding
	Biological Process	Angiogenesis Calcium Ion Transport Intracellular Protein Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Transport Receptor Internalization Cellular Response To Hormone Stimulus Positive Regulation Of Protein Glycosylation Protein Localization To Plasma Membrane Amylin Receptor Signaling Pathway Amylin Receptor 1 Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors	G alpha (s) signalling events Glucagon-type ligand receptors
Drugs		Pramlintide
Diseases
GWAS		Obesity-related traits ( 23251661) Resting metabolic rate ( 28476931)	Bipolar disorder ( 31043756) Cerebrospinal fluid clusterin levels ( 26545630) Hip circumference adjusted for BMI ( 28552196) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189)
Interacting Genes		10 interacting genes: CALCA CALCR CALCRL DCLK3 IAPP MAL MS4A13 NKG7 SLC31A2 VIPR1	16 interacting genes: ADCYAP1 CALM1 GNAI1 GNAQ GNAS GPRASP1 PFN1 PRDM5 PTMA RAMP1 RAMP2 RAMP3 SCT TINF2 VIP WASL
Entrez ID		10267	7433
HPRD ID		05515	01890
Ensembl ID		ENSG00000132329	ENSG00000114812
Uniprot IDs		E9PC20 O60894	B4DNY6 P32241
PDB IDs		2YX8 3N7P 3N7R 3N7S 4RWG 5V6Y 6D1U 6E3Y 6UMG 6ZHO 6ZIS 7KNT 7KNU 7P0F 7P0I 7TYF 7TYW 8AX5 8AX6 8AX7 9AUC	1OF2 1OGT 3B3I 3B6S 3DTX 3HCV 5DEF 5DEG 5IB1 5IB2 5IB3 5IB4 5IB5 6VN7 7ALO 8E3Y 8E3Z
Enriched GO Terms of Interacting Partners?		Calcitonin Family Receptor Signaling Pathway Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway Amylin Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcitonin Receptor Activity Amylin Receptor 3 Signaling Pathway Calcitonin Gene-related Peptide Receptor Activity Negative Regulation Of Bone Resorption G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Bone Remodeling Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Osteoclast Differentiation Regulation Of Bone Resorption Transmembrane Signaling Receptor Activity Regulation Of Bone Remodeling Regulation Of CAMP/PKA Signal Transduction Osteoclast Differentiation Negative Regulation Of Myeloid Leukocyte Differentiation Amylin Receptor Complex 2 Calcitonin Family Receptor Activity Positive Regulation Of Calcium-mediated Signaling Amylin Receptor Complex 1 Calcitonin Binding Regulation Of Copper Ion Transmembrane Transport Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Sucrose Stimulus Regulation Of Osteoclast Differentiation Receptor Internalization Regulation Of Tissue Remodeling Calcitonin Receptor Binding Amyloid-beta Binding Amylin Receptor Complex 3 G Protein-coupled Receptor Activity Adrenomedullin Binding CGRP Receptor Complex Negative Regulation Of Myeloid Cell Differentiation Regulation Of Calcium-mediated Signaling Amylin Receptor Activity Membrane Raft Polarization Vasoactive Intestinal Polypeptide Receptor Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Adrenomedullin Receptor Complex Adrenomedullin Receptor Activity Hormone Activity	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of CAMP/PKA Signal Transduction Amylin Receptor Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Calcitonin Family Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Guanyl Nucleotide Binding Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding G-protein Beta/gamma-subunit Complex Binding Response To Prostaglandin E Adrenomedullin Receptor Activity Adrenomedullin Receptor Complex Amylin Receptor Activity Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Heterotrimeric G-protein Complex Adenylate Cyclase Regulator Activity Adenylate Cyclase Activator Activity Adrenomedullin Receptor Signaling Pathway Response To Hormone Coreceptor Activity Regulation Of Peptide Hormone Secretion G Protein Activity Receptor Internalization G Protein-coupled Receptor Binding Peptide Hormone Receptor Binding Activation Of Adenylate Cyclase Activity Regulation Of Signal Transduction Regulation Of Hormone Secretion Regulation Of Hormone Levels Neuropeptide Signaling Pathway Regulation Of Protein Localization Regulation Of Body Fluid Levels Positive Regulation Of Adenylate Cyclase Activity Cellular Response To Acidic PH Hormone Activity Positive Regulation Of Lyase Activity Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Protein Secretion Regulation Of Biological Quality Positive Regulation Of Cyclase Activity Regulation Of Metabolic Process G Protein-coupled Serotonin Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Cellular Response To Hormone Stimulus
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