RAMP1 and CALCRL

Number of citations of the paper that reports this interaction (PubMedID 12684503)
0

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro, in vivo)

		RAMP1	CALCRL
Description		receptor activity modifying protein 1	calcitonin receptor like receptor
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Receptor Complex CGRP Receptor Complex	Cytoplasm Lysosome Endosome Endoplasmic Reticulum Plasma Membrane Membrane Adrenomedullin Receptor Complex CGRP Receptor Complex
	Molecular Function	Calcitonin Gene-related Peptide Receptor Activity Protein Binding Coreceptor Activity Amylin Receptor Activity Calcitonin Gene-related Peptide Binding	Adrenomedullin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcitonin Receptor Activity Protein Binding Adrenomedullin Binding
	Biological Process	Angiogenesis Calcium Ion Transport Intracellular Protein Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Transport Receptor Internalization Cellular Response To Hormone Stimulus Positive Regulation Of Protein Glycosylation Protein Localization To Plasma Membrane Amylin Receptor Signaling Pathway Amylin Receptor 1 Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway	Angiogenesis Calcium Ion Transport Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Protein Transport Receptor Internalization Smooth Muscle Cell Proliferation Cellular Response To Sucrose Stimulus Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Calcitonin Gene-related Peptide Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway Vascular Associated Smooth Muscle Cell Proliferation
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors	G alpha (s) signalling events Calcitonin-like ligand receptors High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Pramlintide	Olcegepant Telcagepant Rimegepant Erenumab Ubrogepant Zavegepant Atogepant
Diseases
GWAS		Obesity-related traits ( 23251661) Resting metabolic rate ( 28476931)	A body shape index ( 34021172) Aspartate aminotransferase levels ( 33547301) Body mass index ( 25673413) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Periventricular white matter hyperintensities ( 32517579) Resting heart rate ( 27798624) Serum immune biomarker levels ( 32066700) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412) White blood cell count ( 32888494) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		10 interacting genes: CALCA CALCR CALCRL DCLK3 IAPP MAL MS4A13 NKG7 SLC31A2 VIPR1	6 interacting genes: ADM CALCA CRCP RAMP1 RAMP2 RAMP3
Entrez ID		10267	10203
HPRD ID		05515	11809
Ensembl ID		ENSG00000132329	ENSG00000064989
Uniprot IDs		E9PC20 O60894	Q16602
PDB IDs		2YX8 3N7P 3N7R 3N7S 4RWG 5V6Y 6D1U 6E3Y 6UMG 6ZHO 6ZIS 7KNT 7KNU 7P0F 7P0I 7TYF 7TYW 8AX5 8AX6 8AX7 9AUC	3AQF 3N7P 3N7R 3N7S 4RWF 4RWG 5V6Y 6D1U 6E3Y 6UMG 6UUN 6UUS 6UVA 6V2E 6ZHO 6ZIS 7KNT 7KNU 7P0F 7P0I 8AX5 8AX6 8AX7
Enriched GO Terms of Interacting Partners?		Calcitonin Family Receptor Signaling Pathway Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway Amylin Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcitonin Receptor Activity Amylin Receptor 3 Signaling Pathway Calcitonin Gene-related Peptide Receptor Activity Negative Regulation Of Bone Resorption G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Bone Remodeling Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Osteoclast Differentiation Regulation Of Bone Resorption Transmembrane Signaling Receptor Activity Regulation Of Bone Remodeling Regulation Of CAMP/PKA Signal Transduction Osteoclast Differentiation Negative Regulation Of Myeloid Leukocyte Differentiation Amylin Receptor Complex 2 Calcitonin Family Receptor Activity Positive Regulation Of Calcium-mediated Signaling Amylin Receptor Complex 1 Calcitonin Binding Regulation Of Copper Ion Transmembrane Transport Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Sucrose Stimulus Regulation Of Osteoclast Differentiation Receptor Internalization Regulation Of Tissue Remodeling Calcitonin Receptor Binding Amyloid-beta Binding Amylin Receptor Complex 3 G Protein-coupled Receptor Activity Adrenomedullin Binding CGRP Receptor Complex Negative Regulation Of Myeloid Cell Differentiation Regulation Of Calcium-mediated Signaling Amylin Receptor Activity Membrane Raft Polarization Vasoactive Intestinal Polypeptide Receptor Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Adrenomedullin Receptor Complex Adrenomedullin Receptor Activity Hormone Activity	Calcitonin Family Receptor Signaling Pathway Amylin Receptor Signaling Pathway Receptor Internalization Adrenomedullin Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Endocytosis Adrenomedullin Receptor Activity Adrenomedullin Receptor Complex Amylin Receptor Activity Import Into Cell Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Calcitonin Gene-related Peptide Receptor Activity Coreceptor Activity Calcitonin Gene-related Peptide Receptor Signaling Pathway Antifungal Humoral Response Vascular Associated Smooth Muscle Cell Development Positive Regulation Of Vasculogenesis Vesicle-mediated Transport G Protein-coupled Receptor Internalization Response To Yeast Regulation Of Vasculogenesis Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Regulation Of Blood Pressure Protein Localization To Plasma Membrane Receptor Complex Protein Localization To Cell Periphery Calcium Ion Transport Vascular Process In Circulatory System Regulation Of Vascular Permeability Protein Localization To Membrane Circulatory System Process Defense Response To Fungus Cellular Response To Hormone Stimulus Response To Fungus Antibacterial Humoral Response Vasculogenesis Signal Transduction Adrenomedullin Receptor Binding Positive Regulation Of Progesterone Biosynthetic Process Calcitonin Gene-related Peptide Binding Cross-receptor Inhibition Within G Protein-coupled Receptor Heterodimer DNA Polymerase III Complex Defense Response To Gram-negative Bacterium Positive Regulation Of Biosynthetic Process Muscle Cell Development
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