RAMP2

Description		receptor activity modifying protein 2
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GO Annotations	Cellular Component	Cytoplasm Lysosome Plasma Membrane Clathrin-coated Pit Cell Surface Membrane Receptor Complex Adrenomedullin Receptor Complex
	Molecular Function	Adrenomedullin Receptor Activity Protein Binding Coreceptor Activity Adrenomedullin Binding
	Biological Process	Angiogenesis Vasculogenesis Sprouting Angiogenesis Calcium Ion Transport Intracellular Protein Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Regulation Of Blood Pressure Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Protein Transport Receptor Internalization Cellular Response To Hormone Stimulus Adherens Junction Assembly Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Bicellular Tight Junction Assembly Basement Membrane Assembly Protein Localization To Plasma Membrane Vascular Associated Smooth Muscle Cell Development Amylin Receptor 2 Signaling Pathway Adrenomedullin Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Vasculogenesis
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Pramlintide
Diseases
GWAS		A body shape index ( 34021172) Pulse pressure ( 30224653) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		7 interacting genes: CALCA CALCRL CIDEB IAPP LCN2 SLC31A2 VIPR1
Entrez ID		10266
HPRD ID		05516
Ensembl ID		ENSG00000131477
Uniprot IDs		O60895
PDB IDs		2XVT 3AQE 3AQF 4RWF 6UUN 6V2E 7TYH 7TYX 7TYY
Enriched GO Terms of Interacting Partners?		Calcitonin Family Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway Amylin Receptor Signaling Pathway Negative Regulation Of Bone Resorption Negative Regulation Of Bone Remodeling Negative Regulation Of Osteoclast Differentiation Regulation Of Bone Resorption Response To Nerve Growth Factor G Protein-coupled Receptor Signaling Pathway Regulation Of Bone Remodeling Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To Nerve Growth Factor Stimulus Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Myeloid Leukocyte Differentiation G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Metal Ion Transport Receptor Internalization Regulation Of Osteoclast Differentiation Regulation Of Copper Ion Transmembrane Transport Positive Regulation Of Hippocampal Neuron Apoptotic Process Cellular Response To Sucrose Stimulus Regulation Of Tissue Remodeling Regulation Of Monoatomic Ion Transport Calcitonin Receptor Binding Cellular Response To Tumor Necrosis Factor Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Iron Ion Import Across Plasma Membrane Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Adrenomedullin Binding CGRP Receptor Complex Calcitonin Receptor Activity Hormone Activity Negative Regulation Of Hemopoiesis Positive Regulation Of Apoptotic Process Regulation Of Myeloid Leukocyte Differentiation Receptor Ligand Activity Response To Tumor Necrosis Factor Positive Regulation Of Programmed Cell Death Amylin Receptor 3 Signaling Pathway Siderophore Transport Vasoactive Intestinal Polypeptide Receptor Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Adrenomedullin Receptor Complex Adrenomedullin Receptor Activity
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