RAMP2 and VIPR1

Number of citations of the paper that reports this interaction (PubMedID 12446722)
0

Data Source:
HPRD (in vitro)

		RAMP2	VIPR1
Description		receptor activity modifying protein 2	vasoactive intestinal peptide receptor 1
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Plasma Membrane Clathrin-coated Pit Cell Surface Membrane Receptor Complex Adrenomedullin Receptor Complex	Plasma Membrane Membrane Receptor Complex
	Molecular Function	Adrenomedullin Receptor Activity Protein Binding Coreceptor Activity Adrenomedullin Binding	Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Vasoactive Intestinal Polypeptide Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding
	Biological Process	Angiogenesis Vasculogenesis Sprouting Angiogenesis Calcium Ion Transport Intracellular Protein Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Regulation Of Blood Pressure Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Protein Transport Receptor Internalization Cellular Response To Hormone Stimulus Adherens Junction Assembly Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Bicellular Tight Junction Assembly Basement Membrane Assembly Protein Localization To Plasma Membrane Vascular Associated Smooth Muscle Cell Development Amylin Receptor 2 Signaling Pathway Adrenomedullin Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Vasculogenesis	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	G alpha (s) signalling events Glucagon-type ligand receptors
Drugs		Pramlintide
Diseases
GWAS		A body shape index ( 34021172) Pulse pressure ( 30224653) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Bipolar disorder ( 31043756) Cerebrospinal fluid clusterin levels ( 26545630) Hip circumference adjusted for BMI ( 28552196) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189)
Interacting Genes		7 interacting genes: CALCA CALCRL CIDEB IAPP LCN2 SLC31A2 VIPR1	16 interacting genes: ADCYAP1 CALM1 GNAI1 GNAQ GNAS GPRASP1 PFN1 PRDM5 PTMA RAMP1 RAMP2 RAMP3 SCT TINF2 VIP WASL
Entrez ID		10266	7433
HPRD ID		05516	01890
Ensembl ID		ENSG00000131477	ENSG00000114812
Uniprot IDs		O60895	B4DNY6 P32241
PDB IDs		2XVT 3AQE 3AQF 4RWF 6UUN 6V2E 7TYH 7TYX 7TYY	1OF2 1OGT 3B3I 3B6S 3DTX 3HCV 5DEF 5DEG 5IB1 5IB2 5IB3 5IB4 5IB5 6VN7 7ALO 8E3Y 8E3Z
Enriched GO Terms of Interacting Partners?		Calcitonin Family Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway Amylin Receptor Signaling Pathway Negative Regulation Of Bone Resorption Negative Regulation Of Bone Remodeling Negative Regulation Of Osteoclast Differentiation Regulation Of Bone Resorption Response To Nerve Growth Factor G Protein-coupled Receptor Signaling Pathway Regulation Of Bone Remodeling Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To Nerve Growth Factor Stimulus Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Myeloid Leukocyte Differentiation G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Metal Ion Transport Receptor Internalization Regulation Of Osteoclast Differentiation Regulation Of Copper Ion Transmembrane Transport Positive Regulation Of Hippocampal Neuron Apoptotic Process Cellular Response To Sucrose Stimulus Regulation Of Tissue Remodeling Regulation Of Monoatomic Ion Transport Calcitonin Receptor Binding Cellular Response To Tumor Necrosis Factor Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Iron Ion Import Across Plasma Membrane Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Adrenomedullin Binding CGRP Receptor Complex Calcitonin Receptor Activity Hormone Activity Negative Regulation Of Hemopoiesis Positive Regulation Of Apoptotic Process Regulation Of Myeloid Leukocyte Differentiation Receptor Ligand Activity Response To Tumor Necrosis Factor Positive Regulation Of Programmed Cell Death Amylin Receptor 3 Signaling Pathway Siderophore Transport Vasoactive Intestinal Polypeptide Receptor Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Adrenomedullin Receptor Complex Adrenomedullin Receptor Activity	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of CAMP/PKA Signal Transduction Amylin Receptor Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Calcitonin Family Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Guanyl Nucleotide Binding Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding G-protein Beta/gamma-subunit Complex Binding Response To Prostaglandin E Adrenomedullin Receptor Activity Adrenomedullin Receptor Complex Amylin Receptor Activity Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Heterotrimeric G-protein Complex Adenylate Cyclase Regulator Activity Adenylate Cyclase Activator Activity Adrenomedullin Receptor Signaling Pathway Response To Hormone Coreceptor Activity Regulation Of Peptide Hormone Secretion G Protein Activity Receptor Internalization G Protein-coupled Receptor Binding Peptide Hormone Receptor Binding Activation Of Adenylate Cyclase Activity Regulation Of Signal Transduction Regulation Of Hormone Secretion Regulation Of Hormone Levels Neuropeptide Signaling Pathway Regulation Of Protein Localization Regulation Of Body Fluid Levels Positive Regulation Of Adenylate Cyclase Activity Cellular Response To Acidic PH Hormone Activity Positive Regulation Of Lyase Activity Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Protein Secretion Regulation Of Biological Quality Positive Regulation Of Cyclase Activity Regulation Of Metabolic Process G Protein-coupled Serotonin Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Cellular Response To Hormone Stimulus
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