HSPA9 and FGF1

Number of citations: 37 (PubMedID 10510314)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		HSPA9	FGF1
Name		heat shock protein family A (Hsp70) member 9	fibroblast growth factor 1
Structure
GO Annotations	Cellular Component	SAM Complex Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Mitochondrial Matrix Focal Adhesion Mitochondrial Nucleoid Extracellular Exosome MIB Complex	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Cell Cortex Extracellular Matrix
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Fibroblast Growth Factor Receptor Binding Integrin Binding Protein Binding Growth Factor Activity Heparin Binding S100 Protein Binding
	Biological Process	Protein Folding Protein Export From Nucleus Intracellular Protein Transport Inner Mitochondrial Membrane Organization Iron-sulfur Cluster Assembly Erythrocyte Differentiation Calcium Import Into The Mitochondrion Protein Refolding Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Erythrocyte Differentiation Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Hemopoiesis	Angiogenesis Branching Involved In Ureteric Bud Morphogenesis Organ Induction Signal Transduction Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Anatomical Structure Morphogenesis Positive Regulation Of Endothelial Cell Migration Neurogenesis Cell Differentiation Lung Development Regulation Of Cell Migration Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Cellular Response To Heat Wound Healing Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of ERK1 And ERK2 Cascade Mesonephric Epithelium Development Regulation Of Endothelial Tube Morphogenesis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Sprouting Angiogenesis Regulation Of Morphogenesis Of An Epithelium Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Pathways		Mitochondrial protein import Regulation of HSF1-mediated heat shock response Complex I biogenesis Cristae formation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt) Complex III assembly	PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR1b ligand binding and activation FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR2b ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR2 IIIa TM
Drugs		None	Pentosan polysulfate Amlexanox Heparin Sucrosofate Formic acid O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine Naphthalene Trisulfonate Pazopanib 5-aminonaphthalene-2-sulfonic acid Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321 ) Schizophrenia ( 25056061 29483656 )	A body shape index ( 34021172 ) Cardiac hypertrophy ( 21348951 ) Central corneal thickness ( 29760442 32528159 ) Coronary artery disease ( 33020668 ) Erosive tooth wear (severe vs non-severe) ( 29898447 ) Erosive tooth wear (severe vs none or mild) ( 29898447 ) Hip index ( 34021172 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-hip ratio ( 31217584 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		31 interacting genes: APP DNAJC19 DNLZ ERBB2 ERCC6 FGF1 HSP90B1 HSPBP1 LAMTOR5 LCOR LINC01554 LSM8 MATK MVD NEDD8 NELFB OGT PTPN11 PTPRF RNF10 RNF26 SIRPA STUB1 SUMO2 SUMO4 SUPT6H TP53 USP7 XPO1 YKT6 YWHAG	16 interacting genes: CSNK2A1 CSNK2A2 CSNK2B FGFBP1 FGFR1 FGFR2 FGFR3 FGFR4 FIBP HSPA9 NRP1 PTX3 RPS2 S100A13 SYT1 VBP1
Entrez ID		3313	2246
HPRD ID		02770	00567
Ensembl ID		ENSG00000113013	ENSG00000113578
Uniprot IDs		A0A384P5G6 P38646	A8K147 P05230 Q16089
PDB IDs		3N8E 4KBO 6NHK 6P2U 6PMT 9BLS 9BLT 9BLU	1AXM 1DJS 1DZC 1DZD 1E0O 1EVT 1HKN 1JQZ 1JT3 1JT4 1JT5 1JT7 1JTC 1JY0 1K5U 1K5V 1M16 1NZK 1P63 1PZZ 1Q03 1Q04 1RG8 1RML 1RY7 1YTO 1Z2V 1Z4S 2AFG 2AQZ 2AXM 2ERM 2HW9 2HWA 2HWM 2HZ9 2K43 2K4A 2K8R 2KI4 2KI6 2NTD 2Q9X 2RQ9 3B9U 3BA4 3BA5 3BA7 3BAD 3BAG 3BAH 3BAO 3BAQ 3BAU 3BAV 3BB2 3CQA 3CRG 3CRH 3CRI 3CU1 3FGM 3FJ8 3FJ9 3FJA 3FJB 3FJC 3FJD 3FJE 3FJF 3FJH 3FJI 3FJJ 3FJK 3HOM 3JUT 3K1X 3O3Q 3OJ2 3OJM 3OJV 3UD7 3UD8 3UD9 3UDA 4J23 4Q91 4Q9G 4Q9P 4QAL 4QBC 4QBV 4QC4 4QO3 4XKI 4YOL
GO Terms Enriched among Interactors		Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Growth Factor Activity Regulation Of Phosphorus Metabolic Process Protein Modification Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Protein Tag Activity Regulation Of Proteasomal Protein Catabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Protein Localization To Organelle Regulation Of Protein Metabolic Process Regulation Of Macromolecule Biosynthetic Process Receptor Tyrosine Kinase Binding Protein Modification By Small Protein Conjugation TORC1 Signaling Regulation Of Protein Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Protein-containing Complex Positive Regulation Of Gene Expression Regulation Of Purine Nucleotide Metabolic Process TOR Signaling Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Metabolic Process Intracellular Protein Localization Post-translational Protein Modification Regulation Of Cell Activation Regulation Of TORC1 Signaling Regulation Of Small Molecule Metabolic Process Positive Regulation Of Proteolysis Protein-folding Chaperone Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Cytokine Activity Regulation Of Protein Localization Positive Regulation Of Cell Population Proliferation Regulation Of Lymphocyte Activation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Protein Metabolic Process Developmental Growth Protein Stabilization Positive Regulation Of Cell Activation Cellular Response To Manganese Ion	Fibroblast Growth Factor Binding Fibroblast Growth Factor Receptor Activity Fibroblast Growth Factor Receptor Signaling Pathway Protein Kinase CK2 Complex Positive Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Heparin Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Receptor Complex Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway PcG Protein Complex Positive Regulation Of Growth Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Protein Metabolic Process Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Positive Regulation Of Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Protein Kinase Activity Protein Tyrosine Kinase Activity Positive Regulation Of Catalytic Activity Regulation Of Developmental Growth Forebrain Neuroblast Division Positive Regulation Of Cell Population Proliferation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Growth Cell-cell Signaling Kinase Activity Forebrain Ventricular Zone Progenitor Cell Division Peptidyl-tyrosine Phosphorylation Positive Regulation Of Developmental Growth Signaling Cell Communication Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Endothelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Lung-associated Mesenchyme Development Positive Regulation Of Epithelial Cell Proliferation Endochondral Bone Growth Extracellular Region Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction