FGF1 and S100A13

Number of citations of the paper that reports this interaction (PMID 11432880)
27

Data Source:
HPRD (in vivo, in vitro)

		FGF1	S100A13
Gene Name		fibroblast growth factor 1 (acidic)	S100 calcium binding protein A13
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Nucleoplasm Nucleolus Cytosol Cell Cortex	Extracellular Space Nucleus Cytoplasm Cytosol Mast Cell Granule Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Hsp70 Protein Binding S100 Protein Binding	Copper Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Lipid Binding Fibroblast Growth Factor Binding Protein Homodimerization Activity RAGE Receptor Binding
	Biological Process	Angiogenesis Organ Induction Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Multicellular Organismal Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Anatomical Structure Morphogenesis Lung Development Positive Regulation Of Cell Migration Cellular Response To Heat Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of ERK1 And ERK2 Cascade Mesonephric Epithelium Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor	Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Mast Cell Degranulation Response To Copper Ion Cytokine Secretion Interleukin-1 Alpha Secretion Response To Electrical Stimulus
Pathways		Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Signaling by FGFR2 mutants DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade Signaling by activated point mutants of FGFR1 Signaling by FGFR1 mutants PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer Activated point mutants of FGFR2 PI3K events in ERBB4 signaling Signaling by ERBB2 FGFR4 ligand binding and activation Signaling by EGFR Signaling by FGFR3 mutants Downstream signal transduction Signaling by activated point mutants of FGFR3 Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling FGFR1b ligand binding and activation Downstream signaling of activated FGFR FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR ligand binding and activation FGFR2b ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane FGFR3 ligand binding and activation Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR FRS2-mediated cascade FGFR2 ligand binding and activation IRS-mediated signalling FGFR1 ligand binding and activation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs		Pentosan Polysulfate Amlexanox Sucrose Octasulfate Formic Acid O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine Naphthalene Trisulfonate Pazopanib 5-AMINO-NAPHTALENE-2-MONOSULFONATE	Olopatadine Amlexanox
Diseases
GWAS		Cardiac hypertrophy ( 21348951)
Protein-Protein Interactions		14 interactors: CSNK2A1 CSNK2A2 CSNK2B FGFBP1 FGFR1 FGFR2 FGFR3 FGFR4 FIBP HSPA9 NRP1 RPS2 S100A13 SYT1	7 interactors: FGF1 IGBP1 IL1A IRF9 PHYHIP PLEKHF2 SYT1
Entrez ID		2246	6284
HPRD ID		00567	03586
Ensembl ID		ENSG00000113578	ENSG00000189171
Uniprot IDs		A8K147 P05230 Q16089	Q99584
PDB IDs		1AXM 1DJS 1DZC 1DZD 1E0O 1EVT 1HKN 1JQZ 1JT3 1JT4 1JT5 1JT7 1JTC 1JY0 1K5U 1K5V 1M16 1NZK 1P63 1PZZ 1Q03 1Q04 1QCT 1RG8 1RML 1RY7 1YTO 1Z2V 1Z4S 2AFG 2AQZ 2AXM 2ERM 2HW9 2HWA 2HWM 2HZ9 2K43 2K4A 2K8R 2KI4 2KI6 2LDN 2NTD 2Q9X 2RQ9 3B9U 3BA4 3BA5 3BA7 3BAD 3BAG 3BAH 3BAO 3BAQ 3BAU 3BAV 3BB2 3CQA 3CRG 3CRH 3CRI 3CU1 3FGM 3FJ8 3FJ9 3FJA 3FJB 3FJC 3FJD 3FJE 3FJF 3FJH 3FJI 3FJJ 3FJK 3HOM 3JUT 3K1X 3O3Q 3OJ2 3OJM 3OJV 3UD7 3UD8 3UD9 3UDA	1YUR 1YUS 1YUT 1YUU 2EGD 2H2K 2K8M 2KI4 2KI6 2KOT 2L5X 2LE9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Axonogenesis Axon Development Negative Regulation Of Mitotic Nuclear Division Cell Morphogenesis Involved In Neuron Differentiation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Proliferation Neuron Projection Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Division Neuron Projection Development Protein Phosphorylation Cell Projection Morphogenesis Regulation Of Cellular Component Organization Cell Part Morphogenesis Peptidyl-tyrosine Phosphorylation Cell-cell Signaling Alveolar Secondary Septum Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Cellular Response To Growth Factor Stimulus Neuron Development Cell Fate Commitment Response To Growth Factor Branching Involved In Salivary Gland Morphogenesis Regulation Of Mitotic Nuclear Division Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Signaling Cell Morphogenesis Ventricular Zone Neuroblast Division Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol-mediated Signaling Neuron Differentiation Insulin Receptor Signaling Pathway Cell Projection Organization Tube Development Orbitofrontal Cortex Development Axon Guidance Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Salivary Gland Morphogenesis Phosphorylation Salivary Gland Development Lung Alveolus Development Inner Ear Development Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of ERK1 And ERK2 Cascade	Cellular Response To Heat Branch Elongation Involved In Ureteric Bud Branching Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Response To Heat Regulation Of MAPK Cascade Positive Regulation Of Angiogenesis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Division Response To Cytokine Immune System Process Regulation Of Stress-activated MAPK Cascade Response To Temperature Stimulus Regulation Of ERK1 And ERK2 Cascade Fever Generation Calcium Ion-dependent Exocytosis Of Neurotransmitter Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Ureteric Bud Elongation Regulation Of Angiogenesis Negative Regulation Of Protein Dephosphorylation Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Heat Generation Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Division Wound Healing Involved In Inflammatory Response Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Secretion Response To Metal Ion Type I Interferon Biosynthetic Process Immune Response Regulation Of Phosphorylation Detection Of Calcium Ion Positive Regulation Of Transcription, DNA-templated Defense Response Regulation Of Signaling Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Microtubule-based Movement Signaling Positive Regulation Of Interleukin-2 Biosynthetic Process Cell Communication Type I Interferon Production Positive Regulation Of Organelle Organization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Vesicle Fusion Positive Regulation Of Gene Expression Positive Regulation Of MAPK Cascade
Tagcloud ?		autoradiography cholera csfr edb erba fes fgf2 igfr il1 il2 il3 il4 il6 ils int2 interleukins irreversibly myofibroblasts pdgf pdgfr pim raf rel slot tetradecanoyl tgfa tgfb trk tumoral	anchor bilayer biophysical biphasic c2b calorimetry cu2 destabilized endothermic exothermic fgf1 isothermal itc lacks marginally mrc multiprotein nonclassical p40 phosphatidyl pockets proangiogenic ps synaptotagmin syt1 tb3 titration unilamellar vesicles
Tagcloud (Difference) ?		autoradiography cholera csfr edb erba fes fgf2 igfr il1 il2 il3 il4 il6 ils int2 interleukins irreversibly myofibroblasts pdgf pdgfr pim raf rel slot tetradecanoyl tgfa tgfb trk tumoral	anchor bilayer biophysical biphasic c2b calorimetry cu2 destabilized endothermic exothermic isothermal itc lacks marginally mrc multiprotein nonclassical p40 phosphatidyl pockets proangiogenic ps synaptotagmin syt1 tb3 titration unilamellar vesicles
Tagcloud (Intersection) ?		fgf1