HSPA9 and IL9

Data Source: HiPPIP (Novel)

		HSPA9	IL9
Name		heat shock protein family A (Hsp70) member 9	interleukin 9
Structure
GO Annotations	Cellular Component	SAM Complex Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Mitochondrial Matrix Focal Adhesion Mitochondrial Nucleoid Extracellular Exosome MIB Complex	Extracellular Region Extracellular Space
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Cytokine Activity Cytokine Receptor Binding Interleukin-9 Receptor Binding Growth Factor Activity
	Biological Process	Protein Folding Protein Export From Nucleus Intracellular Protein Transport Inner Mitochondrial Membrane Organization Iron-sulfur Cluster Assembly Erythrocyte Differentiation Calcium Import Into The Mitochondrion Protein Refolding Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Erythrocyte Differentiation Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Hemopoiesis	Inflammatory Response Immune Response Positive Regulation Of Cell Population Proliferation Immunoglobulin Mediated Immune Response B Cell Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Interleukin-5 Production Interleukin-9-mediated Signaling Pathway B Cell Proliferation Regulation Of Receptor Signaling Pathway Via JAK-STAT
Pathways		Mitochondrial protein import Regulation of HSF1-mediated heat shock response Complex I biogenesis Cristae formation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt) Complex III assembly	Interleukin-9 signaling
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321 ) Schizophrenia ( 25056061 29483656 )	Blood protein levels ( 30072576 ) Cerebrospinal fluid p-tau levels in Alzheimer's disease dementia ( 29274321 ) Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (continuous) ( 28628665 ) Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (dichotomous) ( 28628665 )
Interacting Genes		31 interacting genes: APP DNAJC19 DNLZ ERBB2 ERCC6 FGF1 HSP90B1 HSPBP1 LAMTOR5 LCOR LINC01554 LSM8 MATK MVD NEDD8 NELFB OGT PTPN11 PTPRF RNF10 RNF26 SIRPA STUB1 SUMO2 SUMO4 SUPT6H TP53 USP7 XPO1 YKT6 YWHAG	4 interacting genes: IL9R S100A6 S100P SNTA1
Entrez ID		3313	3578
HPRD ID		02770	00910
Ensembl ID		ENSG00000113013	ENSG00000145839
Uniprot IDs		A0A384P5G6 P38646	P15248
PDB IDs		3N8E 4KBO 6NHK 6P2U 6PMT 9BLS 9BLT 9BLU	7OX1 7OX2 7OX3 7OX5 7OX6
GO Terms Enriched among Interactors		Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Growth Factor Activity Regulation Of Phosphorus Metabolic Process Protein Modification Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Protein Tag Activity Regulation Of Proteasomal Protein Catabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Protein Localization To Organelle Regulation Of Protein Metabolic Process Regulation Of Macromolecule Biosynthetic Process Receptor Tyrosine Kinase Binding Protein Modification By Small Protein Conjugation TORC1 Signaling Regulation Of Protein Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Protein-containing Complex Positive Regulation Of Gene Expression Regulation Of Purine Nucleotide Metabolic Process TOR Signaling Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Metabolic Process Intracellular Protein Localization Post-translational Protein Modification Regulation Of Cell Activation Regulation Of TORC1 Signaling Regulation Of Small Molecule Metabolic Process Positive Regulation Of Proteolysis Protein-folding Chaperone Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Cytokine Activity Regulation Of Protein Localization Positive Regulation Of Cell Population Proliferation Regulation Of Lymphocyte Activation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Protein Metabolic Process Developmental Growth Protein Stabilization Positive Regulation Of Cell Activation Cellular Response To Manganese Ion	Interleukin-9 Binding Interleukin-9 Receptor Activity Calcium-dependent Protein Binding Negative Regulation Of Hematopoietic Stem Cell Differentiation Syntrophin Complex