FGF1 and FGFR2

Number of citations of the paper that reports this interaction (PMID 11069186)
128

Data Source:
HPRD (in vivo, in vitro)

		FGF1	FGFR2
Gene Name		fibroblast growth factor 1 (acidic)	fibroblast growth factor receptor 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Nucleoplasm Nucleolus Cytosol Cell Cortex	Extracellular Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Cell Surface Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Extracellular Matrix Intracellular Membrane-bounded Organelle Excitatory Synapse
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Hsp70 Protein Binding S100 Protein Binding	Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding Protein Homodimerization Activity
	Biological Process	Angiogenesis Organ Induction Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Multicellular Organismal Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Anatomical Structure Morphogenesis Lung Development Positive Regulation Of Cell Migration Cellular Response To Heat Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of ERK1 And ERK2 Cascade Mesonephric Epithelium Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Ureteric Bud Development In Utero Embryonic Development Epithelial To Mesenchymal Transition Positive Regulation Of Mesenchymal Cell Proliferation Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Axonogenesis Neuromuscular Junction Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Smoothened Signaling Pathway Post-embryonic Development Embryonic Pattern Specification Organ Morphogenesis Regulation Of Cell Fate Commitment Positive Regulation Of Phospholipase Activity Morphogenesis Of Embryonic Epithelium Peptidyl-tyrosine Phosphorylation Orbitofrontal Cortex Development Ventricular Zone Neuroblast Division Pyramidal Neuron Development Gland Morphogenesis Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Lung Development Epithelial Cell Differentiation Midbrain Development Otic Vesicle Formation Hair Follicle Morphogenesis Lacrimal Gland Development Regulation Of Osteoblast Proliferation Multicellular Organism Growth Organ Growth Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Fc-epsilon Receptor Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Odontogenesis Positive Regulation Of MAPK Cascade Innate Immune Response Cell Fate Commitment Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Lung Alveolus Development Mesodermal Cell Differentiation Synaptic Vesicle Transport Embryonic Digestive Tract Morphogenesis Embryonic Organ Morphogenesis Digestive Tract Development Embryonic Organ Development Reproductive Structure Development Positive Regulation Of Smooth Muscle Cell Proliferation Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Epidermis Morphogenesis Branching Morphogenesis Of A Nerve Mesenchymal Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Cell Division Ventricular Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Limb Bud Formation Bone Development Bone Morphogenesis Coronal Suture Morphogenesis Branching Involved In Prostate Gland Morphogenesis Branching Involved In Salivary Gland Morphogenesis Bud Elongation Involved In Lung Branching Lung Lobe Morphogenesis Lung-associated Mesenchyme Development Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Prostate Gland Morphogenesis Prostate Epithelial Cord Elongation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Lateral Sprouting From An Epithelium Mammary Gland Bud Formation Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Branch Elongation Involved In Salivary Gland Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Mesenchymal Cell Differentiation Involved In Lung Development Mesenchymal Cell Proliferation Involved In Lung Development Endodermal Digestive Tract Morphogenesis Lens Fiber Cell Development Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Signaling by FGFR2 mutants DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade Signaling by activated point mutants of FGFR1 Signaling by FGFR1 mutants PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer Activated point mutants of FGFR2 PI3K events in ERBB4 signaling Signaling by ERBB2 FGFR4 ligand binding and activation Signaling by EGFR Signaling by FGFR3 mutants Downstream signal transduction Signaling by activated point mutants of FGFR3 Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling FGFR1b ligand binding and activation Downstream signaling of activated FGFR FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR ligand binding and activation FGFR2b ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane FGFR3 ligand binding and activation Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR FRS2-mediated cascade FGFR2 ligand binding and activation IRS-mediated signalling FGFR1 ligand binding and activation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade	Signaling by FGFR2 amplification mutants Signaling by FGFR2 mutants Signaling by FGFR in disease Signaling by FGFR mutants Activated point mutants of FGFR2
Drugs		Pentosan Polysulfate Amlexanox Sucrose Octasulfate Formic Acid O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine Naphthalene Trisulfonate Pazopanib 5-AMINO-NAPHTALENE-2-MONOSULFONATE	Palifermin Thalidomide SU4984 4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-Amine Regorafenib Ponatinib
Diseases
GWAS		Cardiac hypertrophy ( 21348951)	Breast cancer ( 21263130 20872241 23354978 17529967 23535729 17529973 22951594 20453838 19330030 21060860) Prostate-specific antigen levels ( 21160077)
Protein-Protein Interactions		14 interactors: CSNK2A1 CSNK2A2 CSNK2B FGFBP1 FGFR1 FGFR2 FGFR3 FGFR4 FIBP HSPA9 NRP1 RPS2 S100A13 SYT1	21 interactors: APP CACNA1D EPHA4 FGF1 FGF10 FGF17 FGF18 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 ITGA5 NEDD4 PAK4 PLCG1 PPM1A PTK2B
Entrez ID		2246	2263
HPRD ID		00567	01492
Ensembl ID		ENSG00000113578	ENSG00000066468
Uniprot IDs		A8K147 P05230 Q16089	D2CGD1 P21802
PDB IDs		1AXM 1DJS 1DZC 1DZD 1E0O 1EVT 1HKN 1JQZ 1JT3 1JT4 1JT5 1JT7 1JTC 1JY0 1K5U 1K5V 1M16 1NZK 1P63 1PZZ 1Q03 1Q04 1QCT 1RG8 1RML 1RY7 1YTO 1Z2V 1Z4S 2AFG 2AQZ 2AXM 2ERM 2HW9 2HWA 2HWM 2HZ9 2K43 2K4A 2K8R 2KI4 2KI6 2LDN 2NTD 2Q9X 2RQ9 3B9U 3BA4 3BA5 3BA7 3BAD 3BAG 3BAH 3BAO 3BAQ 3BAU 3BAV 3BB2 3CQA 3CRG 3CRH 3CRI 3CU1 3FGM 3FJ8 3FJ9 3FJA 3FJB 3FJC 3FJD 3FJE 3FJF 3FJH 3FJI 3FJJ 3FJK 3HOM 3JUT 3K1X 3O3Q 3OJ2 3OJM 3OJV 3UD7 3UD8 3UD9 3UDA	1DJS 1E0O 1EV2 1GJO 1II4 1IIL 1NUN 1OEC 1WVZ 2FDB 2PSQ 2PVF 2PVY 2PWL 2PY3 2PZ5 2PZP 2PZR 2Q0B 3B2T 3CAF 3CLY 3CU1 3DAR 3EUU 3OJ2 3OJM 3RI1 4J95 4J96 4J97 4J98 4J99
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Axonogenesis Axon Development Negative Regulation Of Mitotic Nuclear Division Cell Morphogenesis Involved In Neuron Differentiation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Proliferation Neuron Projection Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Division Neuron Projection Development Protein Phosphorylation Cell Projection Morphogenesis Regulation Of Cellular Component Organization Cell Part Morphogenesis Peptidyl-tyrosine Phosphorylation Cell-cell Signaling Alveolar Secondary Septum Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Cellular Response To Growth Factor Stimulus Neuron Development Cell Fate Commitment Response To Growth Factor Branching Involved In Salivary Gland Morphogenesis Regulation Of Mitotic Nuclear Division Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Signaling Cell Morphogenesis Ventricular Zone Neuroblast Division Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol-mediated Signaling Neuron Differentiation Insulin Receptor Signaling Pathway Cell Projection Organization Tube Development Orbitofrontal Cortex Development Axon Guidance Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Salivary Gland Morphogenesis Phosphorylation Salivary Gland Development Lung Alveolus Development Inner Ear Development Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of ERK1 And ERK2 Cascade	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Phosphatidylinositol-mediated Signaling Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Innate Immune Response Response To Peptide Hormone Immune Response-regulating Signaling Pathway Cellular Response To Organonitrogen Compound Response To Peptide Cell Surface Receptor Signaling Pathway Immune Response Cellular Response To Hormone Stimulus Response To Organonitrogen Compound Response To Hormone Defense Response Immune System Process Signal Transduction Cellular Response To Organic Substance Regulation Of Immune Response Cell-cell Signaling Signaling Positive Regulation Of Cell Division Cell Communication Regulation Of Immune System Process Positive Regulation Of Cell Proliferation Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Cell Differentiation Response To Stress System Development
Tagcloud ?		autoradiography cholera csfr edb erba fes fgf2 igfr il1 il2 il3 il4 il6 ils int2 interleukins irreversibly myofibroblasts pdgf pdgfr pim raf rel slot tetradecanoyl tgfa tgfb trk tumoral	altogether basic bfgf bfgf1 bfgf55 bfgf75 bk1 bk2 chimera chimeras confer fgfr1 fgfr4 fibroblast gfg interacted kb1 kb2 keratinocyte kgf kgf111 kgf31 kgf91 kgfr neutralized neutralizing reciprocal structurally
Tagcloud (Difference) ?		autoradiography cholera csfr edb erba fes fgf2 igfr il1 il2 il3 il4 il6 ils int2 interleukins irreversibly myofibroblasts pdgf pdgfr pim raf rel slot tetradecanoyl tgfa tgfb trk tumoral	altogether basic bfgf bfgf1 bfgf55 bfgf75 bk1 bk2 chimera chimeras confer fgfr1 fgfr4 fibroblast gfg interacted kb1 kb2 keratinocyte kgf kgf111 kgf31 kgf91 kgfr neutralized neutralizing reciprocal structurally
Tagcloud (Intersection) ?