HSPA9 and HSP90B1

Number of citations of the paper that reports this interaction (PMID 12470827)
10

Data Source:
HPRD (in vitro, in vivo)

		HSPA9	HSP90B1
Gene Name		heat shock 70kDa protein 9 (mortalin)	heat shock protein 90kDa beta (Grp94), member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Mitochondrion Focal Adhesion Mitochondrial Nucleoid Extracellular Vesicular Exosome	Extracellular Region Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Focal Adhesion Membrane Midbody Extracellular Matrix Melanosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Endocytic Vesicle Lumen
	Molecular Function	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Unfolded Protein Binding	RNA Binding Calcium Ion Binding Protein Binding ATP Binding Protein Phosphatase Binding Virion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding
	Biological Process	Protein Folding Protein Export From Nucleus Protein Targeting To Mitochondrion Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process	Response To Hypoxia Toll-like Receptor Signaling Pathway Protein Folding Receptor-mediated Endocytosis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Protein Transport ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Actin Rod Assembly Negative Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Cellular Protein Metabolic Process Innate Immune Response Sequestering Of Calcium Ion Cellular Response To ATP
Pathways		Mitochondrial protein import	Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Scavenging by Class A Receptors ATF6-alpha activates chaperones ATF6-alpha activates chaperone genes Unfolded Protein Response (UPR) Innate Immune System
Drugs			Rifabutin 2-Chlorodideoxyadenosine 1-Methoxy-2-(2-Methoxyethoxy)Ethane Adenosine-5\'-Diphosphate N-Ethyl-5\'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE
Diseases
GWAS			Coronary heart disease ( 21626137)
Protein-Protein Interactions		15 interactors: APP DNAJA3 DNAJC19 DNLZ FGF1 HSP90B1 HSPBP1 LSM8 MVD NELFB SUMO4 TP53 XPO1 YKT6 YWHAG	21 interactors: APOB ASGR1 BIRC2 CCT2 CSNK2A1 CSNK2A2 EGFR ERBB2 FANCC HSPA9 LRP1 MAPK6 MDM2 MTTP NKX3-1 POLR2E TG TLR1 TLR2 TLR4 TXNDC11
Entrez ID		3313	7184
HPRD ID		02770	01860
Ensembl ID		ENSG00000113013	ENSG00000166598
Uniprot IDs		P38646	B4DHT9 P14625
PDB IDs		3N8E
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Protein Folding Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Localization Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Mitochondrial DNA Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Protein Transport Establishment Of Protein Localization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intracellular Transport Mitochondrial Genome Maintenance Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Catalytic Activity Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Localization Response To Abiotic Stimulus Positive Regulation Of Cellular Metabolic Process Neuromuscular Junction Development Neuron Apoptotic Process Positive Regulation Of Mitochondrion Organization Cytoplasmic Transport Establishment Of Localization In Cell Immune Response Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of Proteolysis Neuron Death T Cell Differentiation In Thymus Negative Regulation Of Cellular Metabolic Process Cellular Protein Localization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Aging Innate Immune Response Membrane Organization Negative Regulation Of Macromitophagy Synaptic Growth At Neuromuscular Junction Actin Rod Assembly Oligodendrocyte Apoptotic Process Regulation Of Mitochondrion Organization Mitochondrion Organization Negative Regulation Of Hydrolase Activity Intracellular Protein Transport	Cellular Response To Stimulus Response To External Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Detection Of Molecule Of Bacterial Origin Response To Stimulus Innate Immune Response Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Lipoprotein Transport Cellular Response To Triacyl Bacterial Lipopeptide Detection Of Triacyl Bacterial Lipopeptide Negative Regulation Of Mitotic Cell Cycle Cellular Response To Lipid Detection Of Biotic Stimulus Macrophage Activation Response To Abiotic Stimulus Toll-like Receptor Signaling Pathway Positive Regulation Of Nucleocytoplasmic Transport Immune System Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Immune Response Cell Communication Response To Stress Positive Regulation Of Nitric Oxide Biosynthetic Process Activation Of Innate Immune Response Cellular Metabolic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Immune Response Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Transport Defense Response Cellular Protein Metabolic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Transport Detection Of Bacterial Lipoprotein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Innate Immune Response Regulation Of Establishment Of Protein Localization Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cell Proliferation Regulation Of Mitotic Cell Cycle Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Tagcloud ?		5q 5q31 cfu collectively colony comprehensively defect del deleted haploinsufficiency haploinsufficient hematopoiesis heterozygous homozygous implicate intrinsic knockdown knockout lethal lymphopoiesis malignancies observe preb progenitors rnai stat5 supporting viable zebrafish	adaptive attenuates attractive carcinogen ceramides chaperone compensatory controversial cre dena diethyl expansion gp96 grp94 hccs hepatocyte hepatocytes hyperplasia maintains nitrosoamine oncogenesis paralog perturbs pharmacologically predisposes probed recombinase steatotic vital
Tagcloud (Difference) ?		5q 5q31 cfu collectively colony comprehensively defect del deleted haploinsufficiency haploinsufficient hematopoiesis heterozygous homozygous implicate intrinsic knockdown knockout lethal lymphopoiesis malignancies observe preb progenitors rnai stat5 supporting viable zebrafish	adaptive attenuates attractive carcinogen ceramides chaperone compensatory controversial cre dena diethyl expansion gp96 grp94 hccs hepatocyte hepatocytes hyperplasia maintains nitrosoamine oncogenesis paralog perturbs pharmacologically predisposes probed recombinase steatotic vital
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