FGF1 and HSPA9

Number of citations of the paper that reports this interaction (PMID 10510314)
16

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		FGF1	HSPA9
Gene Name		fibroblast growth factor 1 (acidic)	heat shock 70kDa protein 9 (mortalin)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Nucleoplasm Nucleolus Cytosol Cell Cortex	Nucleolus Cytoplasm Mitochondrion Focal Adhesion Mitochondrial Nucleoid Extracellular Vesicular Exosome
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Hsp70 Protein Binding S100 Protein Binding	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Angiogenesis Organ Induction Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Multicellular Organismal Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Anatomical Structure Morphogenesis Lung Development Positive Regulation Of Cell Migration Cellular Response To Heat Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of ERK1 And ERK2 Cascade Mesonephric Epithelium Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor	Protein Folding Protein Export From Nucleus Protein Targeting To Mitochondrion Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process
Pathways		Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Signaling by FGFR2 mutants DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade Signaling by activated point mutants of FGFR1 Signaling by FGFR1 mutants PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer Activated point mutants of FGFR2 PI3K events in ERBB4 signaling Signaling by ERBB2 FGFR4 ligand binding and activation Signaling by EGFR Signaling by FGFR3 mutants Downstream signal transduction Signaling by activated point mutants of FGFR3 Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling FGFR1b ligand binding and activation Downstream signaling of activated FGFR FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR ligand binding and activation FGFR2b ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane FGFR3 ligand binding and activation Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR FRS2-mediated cascade FGFR2 ligand binding and activation IRS-mediated signalling FGFR1 ligand binding and activation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade	Mitochondrial protein import
Drugs		Pentosan Polysulfate Amlexanox Sucrose Octasulfate Formic Acid O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine Naphthalene Trisulfonate Pazopanib 5-AMINO-NAPHTALENE-2-MONOSULFONATE
Diseases
GWAS		Cardiac hypertrophy ( 21348951)
Protein-Protein Interactions		14 interactors: CSNK2A1 CSNK2A2 CSNK2B FGFBP1 FGFR1 FGFR2 FGFR3 FGFR4 FIBP HSPA9 NRP1 RPS2 S100A13 SYT1	15 interactors: APP DNAJA3 DNAJC19 DNLZ FGF1 HSP90B1 HSPBP1 LSM8 MVD NELFB SUMO4 TP53 XPO1 YKT6 YWHAG
Entrez ID		2246	3313
HPRD ID		00567	02770
Ensembl ID		ENSG00000113578	ENSG00000113013
Uniprot IDs		A8K147 P05230 Q16089	P38646
PDB IDs		1AXM 1DJS 1DZC 1DZD 1E0O 1EVT 1HKN 1JQZ 1JT3 1JT4 1JT5 1JT7 1JTC 1JY0 1K5U 1K5V 1M16 1NZK 1P63 1PZZ 1Q03 1Q04 1QCT 1RG8 1RML 1RY7 1YTO 1Z2V 1Z4S 2AFG 2AQZ 2AXM 2ERM 2HW9 2HWA 2HWM 2HZ9 2K43 2K4A 2K8R 2KI4 2KI6 2LDN 2NTD 2Q9X 2RQ9 3B9U 3BA4 3BA5 3BA7 3BAD 3BAG 3BAH 3BAO 3BAQ 3BAU 3BAV 3BB2 3CQA 3CRG 3CRH 3CRI 3CU1 3FGM 3FJ8 3FJ9 3FJA 3FJB 3FJC 3FJD 3FJE 3FJF 3FJH 3FJI 3FJJ 3FJK 3HOM 3JUT 3K1X 3O3Q 3OJ2 3OJM 3OJV 3UD7 3UD8 3UD9 3UDA	3N8E
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Axonogenesis Axon Development Negative Regulation Of Mitotic Nuclear Division Cell Morphogenesis Involved In Neuron Differentiation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Proliferation Neuron Projection Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Division Neuron Projection Development Protein Phosphorylation Cell Projection Morphogenesis Regulation Of Cellular Component Organization Cell Part Morphogenesis Peptidyl-tyrosine Phosphorylation Cell-cell Signaling Alveolar Secondary Septum Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Cellular Response To Growth Factor Stimulus Neuron Development Cell Fate Commitment Response To Growth Factor Branching Involved In Salivary Gland Morphogenesis Regulation Of Mitotic Nuclear Division Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Signaling Cell Morphogenesis Ventricular Zone Neuroblast Division Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol-mediated Signaling Neuron Differentiation Insulin Receptor Signaling Pathway Cell Projection Organization Tube Development Orbitofrontal Cortex Development Axon Guidance Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Salivary Gland Morphogenesis Phosphorylation Salivary Gland Development Lung Alveolus Development Inner Ear Development Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of ERK1 And ERK2 Cascade	Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Protein Folding Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Localization Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Mitochondrial DNA Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Protein Transport Establishment Of Protein Localization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intracellular Transport Mitochondrial Genome Maintenance Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Catalytic Activity Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Localization Response To Abiotic Stimulus Positive Regulation Of Cellular Metabolic Process Neuromuscular Junction Development Neuron Apoptotic Process Positive Regulation Of Mitochondrion Organization Cytoplasmic Transport Establishment Of Localization In Cell Immune Response Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of Proteolysis Neuron Death T Cell Differentiation In Thymus Negative Regulation Of Cellular Metabolic Process Cellular Protein Localization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Aging Innate Immune Response Membrane Organization Negative Regulation Of Macromitophagy Synaptic Growth At Neuromuscular Junction Actin Rod Assembly Oligodendrocyte Apoptotic Process Regulation Of Mitochondrion Organization Mitochondrion Organization Negative Regulation Of Hydrolase Activity Intracellular Protein Transport
Tagcloud ?		autoradiography cholera csfr edb erba fes fgf2 igfr il1 il2 il3 il4 il6 ils int2 interleukins irreversibly myofibroblasts pdgf pdgfr pim raf rel slot tetradecanoyl tgfa tgfb trk tumoral	5q 5q31 cfu collectively colony comprehensively defect del deleted haploinsufficiency haploinsufficient hematopoiesis heterozygous homozygous implicate intrinsic knockdown knockout lethal lymphopoiesis malignancies observe preb progenitors rnai stat5 supporting viable zebrafish
Tagcloud (Difference) ?		autoradiography cholera csfr edb erba fes fgf2 igfr il1 il2 il3 il4 il6 ils int2 interleukins irreversibly myofibroblasts pdgf pdgfr pim raf rel slot tetradecanoyl tgfa tgfb trk tumoral	5q 5q31 cfu collectively colony comprehensively defect del deleted haploinsufficiency haploinsufficient hematopoiesis heterozygous homozygous implicate intrinsic knockdown knockout lethal lymphopoiesis malignancies observe preb progenitors rnai stat5 supporting viable zebrafish
Tagcloud (Intersection) ?