HSPA9 and IL4

		HSPA9	IL4
Description		heat shock protein family A (Hsp70) member 9	interleukin 4
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GO Annotations	Cellular Component	SAM Complex Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Mitochondrial Matrix Focal Adhesion Mitochondrial Nucleoid Extracellular Exosome MIB Complex	Extracellular Region Extracellular Space
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Cytokine Activity Cytokine Receptor Binding Interleukin-4 Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Protein Folding Protein Export From Nucleus Intracellular Protein Transport Inner Mitochondrial Membrane Organization Iron-sulfur Cluster Assembly Erythrocyte Differentiation Calcium Import Into The Mitochondrion Protein Refolding Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Erythrocyte Differentiation Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Hemopoiesis	Negative Regulation Of Transcription By RNA Polymerase II Immune Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Cholesterol Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Macroautophagy B Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Interleukin-4-mediated Signaling Pathway Type 2 Immune Response Positive Regulation Of T Cell Proliferation T Cell Activation B Cell Activation Macrophage Activation Myeloid Dendritic Cell Differentiation Negative Regulation Of Apoptotic Process Regulation Of Isotype Switching Leukocyte Activation Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of T Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Inflammatory Response Regulation Of Immune Response Regulation Of Multicellular Organismal Process Regulation Of Primary Metabolic Process Dendritic Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Positive Regulation Of Amyloid-beta Clearance Positive Regulation Of Cellular Respiration Negative Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of ATP Biosynthetic Process
Pathways		Mitochondrial protein import Regulation of HSF1-mediated heat shock response Complex I biogenesis Cristae formation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt) Complex III assembly	Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling
Drugs			Pascolizumab Dupilumab Romilkimab
Diseases			Asthma
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Schizophrenia ( 25056061 29483656)	Asthma ( 29273806 31619474 31959851) Asthma (childhood onset) ( 29273806 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 25574825) Atopic march ( 26542096) Inflammatory bowel disease ( 23128233) Psoriasis ( 23143594 25574825) Psoriasis vulgaris ( 26626624) Refractive error ( 32231278)
Interacting Genes		31 interacting genes: APP DNAJC19 DNLZ ERBB2 ERCC6 FGF1 HSP90B1 HSPBP1 LAMTOR5 LCOR LINC01554 LSM8 MATK MVD NEDD8 NELFB OGT PTPN11 PTPRF RNF10 RNF26 SIRPA STUB1 SUMO2 SUMO4 SUPT6H TP53 USP7 XPO1 YKT6 YWHAG	7 interacting genes: A2M CD53 FBXO7 IL13RA2 IL2RG IL4R PIK3CD
Entrez ID		3313	3565
HPRD ID		02770	00989
Ensembl ID		ENSG00000113013	ENSG00000113520
Uniprot IDs		A0A384P5G6 P38646	D4HNR6 P05112 Q5FC01 U3LVN1
PDB IDs		3N8E 4KBO 6NHK 6P2U 6PMT 9BLS 9BLT 9BLU	1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7 4YDY 5FHX 6OEL 8A4F 8CGF 8CH7
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Growth Factor Activity Regulation Of Phosphorus Metabolic Process Protein Modification Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Protein Tag Activity Regulation Of Proteasomal Protein Catabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Protein Localization To Organelle Regulation Of Protein Metabolic Process Regulation Of Macromolecule Biosynthetic Process Receptor Tyrosine Kinase Binding Protein Modification By Small Protein Conjugation TORC1 Signaling Regulation Of Protein Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Protein-containing Complex Positive Regulation Of Gene Expression Regulation Of Purine Nucleotide Metabolic Process TOR Signaling Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Metabolic Process Intracellular Protein Localization Post-translational Protein Modification Regulation Of Cell Activation Regulation Of TORC1 Signaling Regulation Of Small Molecule Metabolic Process Positive Regulation Of Proteolysis Protein-folding Chaperone Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Cytokine Activity Regulation Of Protein Localization Positive Regulation Of Cell Population Proliferation Regulation Of Lymphocyte Activation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Protein Metabolic Process Developmental Growth Protein Stabilization Positive Regulation Of Cell Activation Cellular Response To Manganese Ion	Regulation Of Immune System Process Interleukin-4 Receptor Activity Negative Regulation Of Immune System Process Cytokine Receptor Activity Lymphocyte Differentiation Interleukin-4-mediated Signaling Pathway Regulation Of Immunoglobulin Production Mononuclear Cell Differentiation Leukocyte Differentiation Negative Regulation Of Hemopoiesis Positive Regulation Of Myoblast Fusion Regulation Of Hemopoiesis Lymphocyte Activation Leukocyte Mediated Immunity Regulation Of Myoblast Fusion Immune System Process T Cell Differentiation Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Lymphocyte Activation Regulation Of Production Of Molecular Mediator Of Immune Response Leukocyte Activation Receptor Complex Regulation Of Mast Cell Degranulation Regulation Of Lymphocyte Differentiation Regulation Of Cell Activation Cell Activation Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Immunoglobulin Mediated Immune Response Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Cytokine Binding Positive Regulation Of T Cell Activation B Cell Mediated Immunity Negative Regulation Of Cell Development Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Leukocyte Cell-cell Adhesion T Cell Activation Adaptive Immune Response Positive Regulation Of Immunoglobulin Production Positive Regulation Of Alpha-beta T Cell Differentiation Regulation Of Cell Development Negative Regulation Of Lymphocyte Differentiation CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Cell-cell Adhesion Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Lymphocyte Activation Alpha-beta T Cell Differentiation Cellular Developmental Process
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