FGF1 and FGFBP1

Number of citations of the paper that reports this interaction (PubMedID 11509569)
0

Data Source:
HPRD (in vitro)

		FGF1	FGFBP1
Description		fibroblast growth factor 1	fibroblast growth factor binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Cell Cortex Extracellular Matrix	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane
	Molecular Function	Fibroblast Growth Factor Receptor Binding Integrin Binding Protein Binding Growth Factor Activity Heparin Binding S100 Protein Binding	Protein Binding Heparin Binding Fibroblast Growth Factor Binding Growth Factor Binding
	Biological Process	Angiogenesis Branching Involved In Ureteric Bud Morphogenesis Organ Induction Signal Transduction Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Anatomical Structure Morphogenesis Positive Regulation Of Endothelial Cell Migration Neurogenesis Cell Differentiation Lung Development Regulation Of Cell Migration Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Cellular Response To Heat Wound Healing Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of ERK1 And ERK2 Cascade Mesonephric Epithelium Development Regulation Of Endothelial Tube Morphogenesis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Sprouting Angiogenesis Regulation Of Morphogenesis Of An Epithelium Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor	Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Myoblast Proliferation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Myoblast Proliferation
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR1b ligand binding and activation FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR2b ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR2 IIIa TM	FGFR2b ligand binding and activation
Drugs		Pentosan polysulfate Amlexanox Heparin Sucrosofate Formic acid O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine Naphthalene Trisulfonate Pazopanib 5-aminonaphthalene-2-sulfonic acid Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal)
Diseases
GWAS		A body shape index ( 34021172) Cardiac hypertrophy ( 21348951) Central corneal thickness ( 29760442 32528159) Coronary artery disease ( 33020668) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Hip index ( 34021172) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Pre-treatment viral load in HIV-1 infection ( 31219150) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 31217584) Waist-to-hip ratio adjusted for BMI ( 34021172)	Severe insulin-deficient type 2 diabetes ( 34737425)
Interacting Genes		16 interacting genes: CSNK2A1 CSNK2A2 CSNK2B FGFBP1 FGFR1 FGFR2 FGFR3 FGFR4 FIBP HSPA9 NRP1 PTX3 RPS2 S100A13 SYT1 VBP1	7 interacting genes: ANXA1 ASPH FGF1 FGF2 FIBP HSPG2 UBQLN4
Entrez ID		2246	9982
HPRD ID		00567	06371
Ensembl ID		ENSG00000113578	ENSG00000137440
Uniprot IDs		A8K147 P05230 Q16089	Q14512
PDB IDs		1AXM 1DJS 1DZC 1DZD 1E0O 1EVT 1HKN 1JQZ 1JT3 1JT4 1JT5 1JT7 1JTC 1JY0 1K5U 1K5V 1M16 1NZK 1P63 1PZZ 1Q03 1Q04 1RG8 1RML 1RY7 1YTO 1Z2V 1Z4S 2AFG 2AQZ 2AXM 2ERM 2HW9 2HWA 2HWM 2HZ9 2K43 2K4A 2K8R 2KI4 2KI6 2NTD 2Q9X 2RQ9 3B9U 3BA4 3BA5 3BA7 3BAD 3BAG 3BAH 3BAO 3BAQ 3BAU 3BAV 3BB2 3CQA 3CRG 3CRH 3CRI 3CU1 3FGM 3FJ8 3FJ9 3FJA 3FJB 3FJC 3FJD 3FJE 3FJF 3FJH 3FJI 3FJJ 3FJK 3HOM 3JUT 3K1X 3O3Q 3OJ2 3OJM 3OJV 3UD7 3UD8 3UD9 3UDA 4J23 4Q91 4Q9G 4Q9P 4QAL 4QBC 4QBV 4QC4 4QO3 4XKI 4YOL
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Binding Fibroblast Growth Factor Receptor Activity Fibroblast Growth Factor Receptor Signaling Pathway Protein Kinase CK2 Complex Positive Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Heparin Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Receptor Complex Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway PcG Protein Complex Positive Regulation Of Growth Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Protein Metabolic Process Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Positive Regulation Of Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Protein Kinase Activity Protein Tyrosine Kinase Activity Positive Regulation Of Catalytic Activity Regulation Of Developmental Growth Forebrain Neuroblast Division Positive Regulation Of Cell Population Proliferation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Growth Cell-cell Signaling Kinase Activity Forebrain Ventricular Zone Progenitor Cell Division Peptidyl-tyrosine Phosphorylation Positive Regulation Of Developmental Growth Signaling Cell Communication Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Endothelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Lung-associated Mesenchyme Development Positive Regulation Of Epithelial Cell Proliferation Endochondral Bone Growth Extracellular Region Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction	Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Endothelial Cell Migration Integrin Binding Regulation Of Endothelial Cell Migration Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Epithelial Cell Proliferation Organ Induction Fibroblast Growth Factor Receptor Binding Positive Regulation Of Sprouting Angiogenesis Regulation Of Animal Organ Formation Developmental Induction Positive Regulation Of MAP Kinase Activity Regulation Of Protein Metabolic Process Branching Involved In Ureteric Bud Morphogenesis Regulation Of Cell Population Proliferation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Cell Population Proliferation Regulation Of Anatomical Structure Morphogenesis Regulation Of Vasculature Development Regulation Of Angiogenesis Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Sprouting Angiogenesis Angiogenesis Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of MAP Kinase Activity Regulation Of Morphogenesis Of An Epithelium Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Wound Healing Branch Elongation Involved In Ureteric Bud Branching Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Extracellular Matrix Regulation Of Animal Organ Morphogenesis Positive Regulation Of Cell Division Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Endothelial Cell Proliferation Epidermal Cell Differentiation Peptidyl-aspartic Acid 3-dioxygenase Activity Lung Development Response To Wortmannin Positive Regulation Of Inner Ear Receptor Cell Differentiation Positive Regulation Of Cell Fate Specification Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Collagen V Binding Nuclear Proteasome Complex Neurogenesis Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Migration
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