FGF1 and FGFR4

Number of citations of the paper that reports this interaction (PMID 10336501)
28

Data Source:
HPRD (in vitro, in vivo)

		FGF1	FGFR4
Gene Name		fibroblast growth factor 1 (acidic)	fibroblast growth factor receptor 4
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Nucleoplasm Nucleolus Cytosol Cell Cortex	Extracellular Region Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Transport Vesicle
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Hsp70 Protein Binding S100 Protein Binding	Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding
	Biological Process	Angiogenesis Organ Induction Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Multicellular Organismal Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Anatomical Structure Morphogenesis Lung Development Positive Regulation Of Cell Migration Cellular Response To Heat Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of ERK1 And ERK2 Cascade Mesonephric Epithelium Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor	Organ Induction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Extracellular Matrix Disassembly Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Lipid Metabolic Process Fc-epsilon Receptor Signaling Pathway Glucose Homeostasis Innate Immune Response Positive Regulation Of Proteolysis Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Metalloenzyme Activity Phosphate Ion Homeostasis Alveolar Secondary Septum Development Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Bile Acid Biosynthetic Process Response To Bile Acid Regulation Of Cholesterol Homeostasis Positive Regulation Of DNA Biosynthetic Process
Pathways		Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Signaling by FGFR2 mutants DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade Signaling by activated point mutants of FGFR1 Signaling by FGFR1 mutants PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer Activated point mutants of FGFR2 PI3K events in ERBB4 signaling Signaling by ERBB2 FGFR4 ligand binding and activation Signaling by EGFR Signaling by FGFR3 mutants Downstream signal transduction Signaling by activated point mutants of FGFR3 Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling FGFR1b ligand binding and activation Downstream signaling of activated FGFR FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR ligand binding and activation FGFR2b ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane FGFR3 ligand binding and activation Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR FRS2-mediated cascade FGFR2 ligand binding and activation IRS-mediated signalling FGFR1 ligand binding and activation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade	Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation Signaling by FGFR4 mutants PI-3K cascade PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 FGFR4 ligand binding and activation Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR FGFR ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer betaKlotho-mediated ligand binding Signaling by FGFR Klotho-mediated ligand binding FRS2-mediated cascade IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs		Pentosan Polysulfate Amlexanox Sucrose Octasulfate Formic Acid O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine Naphthalene Trisulfonate Pazopanib 5-AMINO-NAPHTALENE-2-MONOSULFONATE	Palifermin Ponatinib
Diseases
GWAS		Cardiac hypertrophy ( 21348951)	Activated partial thromboplastin time ( 22703881)
Protein-Protein Interactions		14 interactors: CSNK2A1 CSNK2A2 CSNK2B FGFBP1 FGFR1 FGFR2 FGFR3 FGFR4 FIBP HSPA9 NRP1 RPS2 S100A13 SYT1	17 interactors: CDH2 EPHA4 FGF1 FGF17 FGF18 FGF19 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 PLCG1 STAT1 STAT3
Entrez ID		2246	2264
HPRD ID		00567	00625
Ensembl ID		ENSG00000113578	ENSG00000160867
Uniprot IDs		A8K147 P05230 Q16089	G3JVM2 J3KPQ0 P22455 Q96KE5
PDB IDs		1AXM 1DJS 1DZC 1DZD 1E0O 1EVT 1HKN 1JQZ 1JT3 1JT4 1JT5 1JT7 1JTC 1JY0 1K5U 1K5V 1M16 1NZK 1P63 1PZZ 1Q03 1Q04 1QCT 1RG8 1RML 1RY7 1YTO 1Z2V 1Z4S 2AFG 2AQZ 2AXM 2ERM 2HW9 2HWA 2HWM 2HZ9 2K43 2K4A 2K8R 2KI4 2KI6 2LDN 2NTD 2Q9X 2RQ9 3B9U 3BA4 3BA5 3BA7 3BAD 3BAG 3BAH 3BAO 3BAQ 3BAU 3BAV 3BB2 3CQA 3CRG 3CRH 3CRI 3CU1 3FGM 3FJ8 3FJ9 3FJA 3FJB 3FJC 3FJD 3FJE 3FJF 3FJH 3FJI 3FJJ 3FJK 3HOM 3JUT 3K1X 3O3Q 3OJ2 3OJM 3OJV 3UD7 3UD8 3UD9 3UDA	1QCT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Axonogenesis Axon Development Negative Regulation Of Mitotic Nuclear Division Cell Morphogenesis Involved In Neuron Differentiation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Proliferation Neuron Projection Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Division Neuron Projection Development Protein Phosphorylation Cell Projection Morphogenesis Regulation Of Cellular Component Organization Cell Part Morphogenesis Peptidyl-tyrosine Phosphorylation Cell-cell Signaling Alveolar Secondary Septum Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Cellular Response To Growth Factor Stimulus Neuron Development Cell Fate Commitment Response To Growth Factor Branching Involved In Salivary Gland Morphogenesis Regulation Of Mitotic Nuclear Division Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Signaling Cell Morphogenesis Ventricular Zone Neuroblast Division Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol-mediated Signaling Neuron Differentiation Insulin Receptor Signaling Pathway Cell Projection Organization Tube Development Orbitofrontal Cortex Development Axon Guidance Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Salivary Gland Morphogenesis Phosphorylation Salivary Gland Development Lung Alveolus Development Inner Ear Development Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of ERK1 And ERK2 Cascade	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Peptide Hormone Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Insulin Stimulus Cellular Response To Peptide Phosphatidylinositol-mediated Signaling Fc-epsilon Receptor Signaling Pathway Insulin Receptor Signaling Pathway Fc Receptor Signaling Pathway Response To Insulin Enzyme Linked Receptor Protein Signaling Pathway Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Response To Growth Factor Immune Response-regulating Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Regulation Of Immune Response Response To Hormone Defense Response Positive Regulation Of Cell Division Positive Regulation Of Cell Proliferation Immune Response Regulation Of Immune System Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Cell Proliferation Regulation Of Cell Division Cell Surface Receptor Signaling Pathway System Development Response To Organic Substance Immune System Process Multicellular Organismal Development Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Anatomical Structure Development Positive Regulation Of MAPK Cascade Developmental Process Cell Differentiation Response To Stress Positive Regulation Of Phosphorylation
Tagcloud ?		autoradiography cholera csfr edb erba fes fgf2 igfr il1 il2 il3 il4 il6 ils int2 interleukins irreversibly myofibroblasts pdgf pdgfr pim raf rel slot tetradecanoyl tgfa tgfb trk tumoral	5q35 boundary british canx centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf
Tagcloud (Difference) ?		autoradiography cholera csfr edb erba fes fgf2 igfr il1 il2 il3 il4 il6 ils int2 interleukins irreversibly myofibroblasts pdgf pdgfr pim raf rel slot tetradecanoyl tgfa tgfb trk tumoral	5q35 boundary british canx centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf
Tagcloud (Intersection) ?