CITED1 and TFAP2B

Number of citations of the paper that reports this interaction (PMID 11744733)
26

Data Source:
BioGRID (pull down)

		CITED1	TFAP2B
Gene Name		Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus
	Molecular Function	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Protein C-terminus Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding LBD Domain Binding Co-SMAD Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Coactivator Activity RNA Polymerase II Transcription Corepressor Activity Enhancer Sequence-specific DNA Binding DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Sequence-specific DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity
	Biological Process	Embryonic Axis Specification Vasculogenesis Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Placenta Development Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Nucleocytoplasmic Transport Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Brain Development Cell Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Wnt Signaling Pathway Melanocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Lipopolysaccharide Response To Insulin Response To Cytokine Response To Interferon-gamma Melanin Biosynthetic Process Pigmentation Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Response To CAMP Mesenchymal To Epithelial Transition SMAD Protein Signal Transduction Labyrinthine Layer Development Spongiotrophoblast Layer Development Response To Interleukin-1 Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-6 Response To Interleukin-9 Response To Interleukin-11 Response To Parathyroid Hormone Response To Transforming Growth Factor Beta	Negative Regulation Of Transcription From RNA Polymerase II Promoter Kidney Development Renal Water Homeostasis Glucose Metabolic Process Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Lithium Ion Retina Layer Formation Magnesium Ion Homeostasis Regulation Of BMP Signaling Pathway Forelimb Morphogenesis Hindlimb Morphogenesis Positive Regulation Of Urine Volume Aorta Morphogenesis Response To Drug Glucose Homeostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Skin Development Fat Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Sympathetic Nervous System Development Regulation Of Insulin Secretion Phosphate Ion Homeostasis Calcium Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Distal Tubule Development Collecting Duct Development Metanephric Nephron Development Ductus Arteriosus Closure Cellular Ammonia Homeostasis Cellular Creatinine Homeostasis Cellular Urea Homeostasis
Pathways
Drugs
Diseases
GWAS			Adiposity ( 19557161) Body mass index ( 23563607 20935630) Metabolic syndrome (bivariate traits) ( 21386085) Obesity ( 23563607) Obesity (extreme) ( 21935397) Renal function-related traits (BUN) ( 22797727)
Protein-Protein Interactions		8 interactors: CREBBP EP300 ESR1 HSPA8 LNX1 SMAD4 TFAP2B TFAP2C	11 interactors: CITED1 CITED2 CITED4 HIST1H2AC LZTR1 MYC SSBP4 SYT4 UBE2I VPS11 YEATS4
Entrez ID		4435	7021
HPRD ID		02146	03360
Ensembl ID		ENSG00000125931	ENSG00000008196
Uniprot IDs		Q99966	Q92481
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Cellular Response To Heat Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Negative Regulation Of Biosynthetic Process Anatomical Structure Morphogenesis Cellular Response To Heat Tube Development Germ-line Stem Cell Maintenance Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Sebaceous Gland Development Regulation Of Transcription From RNA Polymerase II Promoter Response To Heat N-terminal Protein Amino Acid Acetylation RNA Metabolic Process Organ Morphogenesis Positive Regulation Of Metabolic Process Epithelium Development Gene Expression Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Stem Cell Maintenance Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Mammary Gland Epithelial Cell Proliferation Branch Elongation Of An Epithelium Response To Temperature Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Branching Morphogenesis Of An Epithelial Tube Tissue Morphogenesis N-terminal Protein Amino Acid Modification Regulation Of Transcription, DNA-templated Skin Development DNA-templated Transcription, Initiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Morphogenesis Of A Branching Epithelium	Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Organ Morphogenesis Response To Estrogen Positive Regulation Of Transcription, DNA-templated Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Branching Involved In Ureteric Bud Morphogenesis Ureteric Bud Morphogenesis Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Response To Interleukin-11 Positive Regulation Of SUMO Transferase Activity Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nephron Morphogenesis Renal Tubule Morphogenesis Regulation Of RNA Metabolic Process Renal Tubule Development Negative Regulation Of Transcription, DNA-templated Kidney Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Adrenal Cortex Formation Fibroblast Apoptotic Process Response To Steroid Hormone Axis Specification Regulation Of Gene Expression Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Mesonephros Development Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Response To Interleukin-9 Transcription, DNA-templated Negative Regulation Of Gene Expression Nephron Development Negative Regulation Of Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia RNA Biosynthetic Process Kidney Epithelium Development Embryonic Heart Tube Left/right Pattern Formation Positive Regulation Of Cellular Metabolic Process Determination Of Left/right Asymmetry In Lateral Mesoderm
Tagcloud ?		calm3 cblb ccna2 ccnd3 cdk6 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9	438delccgg 5g abnormalities arteriosus char cited2 coactivator congenital constructed cpb defects ductus express facial familial families fingers haploinsufficiency interacting luciferase mutated mutations patent pda plasmids transactivation transactivator transfected
Tagcloud (Difference) ?		calm3 cblb ccna2 ccnd3 cdk6 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9	438delccgg 5g abnormalities arteriosus char cited2 coactivator congenital constructed cpb defects ductus express facial familial families fingers haploinsufficiency interacting luciferase mutated mutations patent pda plasmids transactivation transactivator transfected
Tagcloud (Intersection) ?