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HSPBP1 and HSPA1A
Number of citations of the paper that reports this interaction (PubMedID
9830037
)
0
Data Source:
HPRD
(in vitro, two hybrid)
HSPBP1
HSPA1A
Description
HSPA (Hsp70) binding protein 1
heat shock protein family A (Hsp70) member 1A
Image
GO Annotations
Cellular Component
Extracellular Space
Endoplasmic Reticulum
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Centrosome
Centriole
Cytosol
Cytoskeleton
Plasma Membrane
Focal Adhesion
COP9 Signalosome
Inclusion Body
Aggresome
Nuclear Speck
Vesicle
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Blood Microparticle
Ficolin-1-rich Granule Lumen
Ribonucleoprotein Complex
Molecular Function
Adenyl-nucleotide Exchange Factor Activity
Enzyme Inhibitor Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Molecular Sequestering Activity
Nucleotide Binding
Virus Receptor Activity
G Protein-coupled Receptor Binding
Transcription Corepressor Activity
RNA Binding
Signaling Receptor Binding
Protein Binding
ATP Binding
ATP Hydrolysis Activity
Enzyme Binding
Heat Shock Protein Binding
Denatured Protein Binding
Ubiquitin Protein Ligase Binding
Death Receptor Agonist Activity
Histone Deacetylase Binding
Protein Folding Chaperone
Cadherin Binding
Receptor Ligand Activity
Unfolded Protein Binding
Misfolded Protein Binding
C3HC4-type RING Finger Domain Binding
Disordered Domain Specific Binding
Transcription Regulator Inhibitor Activity
ATP-dependent Protein Disaggregase Activity
ATP-dependent Protein Folding Chaperone
Biological Process
Protein Folding
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
MRNA Catabolic Process
Protein Folding
Response To Unfolded Protein
Lysosomal Transport
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Negative Regulation Of Cell Growth
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Regulation Of Protein Ubiquitination
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of RNA Splicing
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To Unfolded Protein
Protein Refolding
Negative Regulation Of Apoptotic Process
Positive Regulation Of Erythrocyte Differentiation
ATP Metabolic Process
Symbiont Entry Into Host Cell
Protein Stabilization
Positive Regulation Of NF-kappaB Transcription Factor Activity
Chaperone-mediated Protein Complex Assembly
Cellular Heat Acclimation
Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Cellular Response To Steroid Hormone Stimulus
Positive Regulation Of Microtubule Nucleation
Negative Regulation Of Inclusion Body Assembly
Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Mitotic Spindle Assembly
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Viral RNP Complexes in the Host Cell Nucleus
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Attenuation phase
HSF1-dependent transactivation
AUF1 (hnRNP D0) binds and destabilizes mRNA
Neutrophil degranulation
PKR-mediated signaling
Mitochondrial unfolded protein response (UPRmt)
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Attenuation phase
HSF1-dependent transactivation
Neutrophil degranulation
PKR-mediated signaling
Mitochondrial unfolded protein response (UPRmt)
Drugs
Diseases
GWAS
Thyroid stimulating hormone levels (
32769997
)
Asthma (
31619474
)
Asthma (childhood onset) (
31619474
)
Asthma and major depressive disorder (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Inflammatory bowel disease (
28067908
)
Schizophrenia (
30285260
)
Systemic lupus erythematosus (
32771030
)
Ulcerative colitis (
28067908
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
14 interacting genes:
APP
CLK1
EFEMP2
HSPA1A
HSPA1B
HSPA2
HSPA4
HSPA5
HSPA8
HSPA9
KRT27
LRIF1
NOTCH2NLA
PTEN
95 interacting genes:
ACE2
AIFM1
APAF1
APEX1
APOB
ATXN1
BAG1
BAG2
BAG3
BAG4
BCL2
BRSK1
CACNA1E
CDK9
CFAP52
DAPP1
DNAAF4
DNAJA2
DNAJA3
DNAJB1
DNAJB11
DNAJB4
DNAJC3
EGFR
EIF2AK2
EIF4ENIF1
ERBB2
ERBB3
FANCC
FILNC1
FNDC3B
FOS
FTCD
GPR37
GRIN1
GRIN2D
HAP1
HCFC1
HEMGN
HIVEP1
HMGA1
HSBP1
HSF1
HSPA8
HSPBP1
IKBKG
INS
KRT18
KRT7
MAP3K5
MAPRE1
METTL21A
MOS
MSR1
NQO1
NR3C1
OGT
PEX5
PGR
PLG
POT1
PPP1R15A
PRKCA
PSMC5
PTGES3
PTMA
PTPRF
RAP1A
RAPGEF2
RHOA
SAE1
SLC13A1
SLC5A1
SNCB
SNRK
SOX9
ST13
STIP1
STUB1
SUMO2
TCERG1
TGM2
TOMM70
TP53
TRIAP1
TRIM24
TRIM38
TSSK6
TTC1
UBE2D3
XIAP
YWHAB
YWHAG
YWHAQ
YWHAZ
Entrez ID
23640
3303
HPRD ID
09991
00774
Ensembl ID
ENSG00000133265
ENSG00000204389
Uniprot IDs
Q9NZL4
A8K5I0
B3KTT5
P0DMV8
P0DMV9
PDB IDs
1XQR
1XQS
8X87
1HJO
1S3X
1XQS
2E88
2E8A
2LMG
3A8Y
3ATU
3ATV
3AY9
3D2E
3D2F
3JXU
3LOF
3Q49
4IO8
4J8F
4PO2
4WV5
4WV7
5AQW
5AQX
5AQY
5AQZ
5AR0
5BN8
5BN9
5BPL
5BPM
5BPN
5GJJ
5MKR
5MKS
5XI9
5XIR
6FDT
6FHK
6G3R
6G3S
6JPV
6K39
6ZYI
7F4X
7F4Z
7F50
7FGM
7GY4
7GY5
7GY6
7GY7
7GY8
7GY9
7GYA
7GYB
7GYC
7GYD
7GYE
7GYF
7GYG
7GYH
7GYI
7GYJ
7GYK
7GYL
7GYM
7GYN
7GYO
7GYP
7GYQ
7GYR
7GYS
7GYT
7GYU
7GYV
7GYW
7GYX
7KW7
7Q4R
Enriched GO Terms of Interacting Partners
?
ATP-dependent Protein Folding Chaperone
Protein Refolding
Protein Folding Chaperone
Heat Shock Protein Binding
Protein Folding
Enzyme Binding
Unfolded Protein Binding
C3HC4-type RING Finger Domain Binding
ATP-dependent Protein Disaggregase Activity
Negative Regulation Of Inclusion Body Assembly
ATP Hydrolysis Activity
G Protein-coupled Receptor Binding
Extracellular Exosome
Regulation Of Inclusion Body Assembly
Response To Unfolded Protein
Protein-folding Chaperone Binding
Regulation Of Protein Import
Blood Microparticle
Ubiquitin Protein Ligase Binding
ATP Binding
Regulation Of Erythrocyte Differentiation
Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Cellular Heat Acclimation
Negative Regulation Of Cellular Component Organization
Focal Adhesion
Positive Regulation Of Proteolysis
Nucleotide Binding
Positive Regulation Of Microtubule Nucleation
Cellular Response To Steroid Hormone Stimulus
Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Response To Heat
Regulation Of Response To Endoplasmic Reticulum Stress
Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Misfolded Protein Binding
Inclusion Body
Regulation Of Microtubule Nucleation
Ficolin-1-rich Granule Lumen
Receptor Ligand Activity
Chaperone-mediated Protein Complex Assembly
Regulation Of Mitotic Spindle Assembly
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Protein Stability
Negative Regulation Of Cell Population Proliferation
Regulation Of Proteolysis
Regulation Of Supramolecular Fiber Organization
Response To Temperature Stimulus
Regulation Of Cellular Component Organization
Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Programmed Cell Death
Protein-folding Chaperone Binding
Protein Folding
Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Cytosol
Positive Regulation Of Macromolecule Metabolic Process
Protein Folding Chaperone Complex
Negative Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Apoptotic Process
Cytoplasm
Intracellular Signal Transduction
Heat Shock Protein Binding
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Cellular Response To Stress
Protein-containing Complex
Intracellular Signaling Cassette
Ubiquitin Protein Ligase Binding
Response To Stress
Regulation Of Protein Metabolic Process
Hsp70 Protein Binding
Signal Transduction
Negative Regulation Of Macromolecule Biosynthetic Process
Adenyl-nucleotide Exchange Factor Activity
Apoptotic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Stability
Response To Heat
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Programmed Cell Death
Negative Regulation Of RNA Metabolic Process
Cell Death
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Oxygen-containing Compound
Regulation Of Signal Transduction
Negative Regulation Of DNA-templated Transcription
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Response To Temperature Stimulus
Neuron Apoptotic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Intracellular Signal Transduction
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