HSPBP1 and HSPA9

Number of citations of the paper that reports this interaction (PMID 19659607)
11

Data Source:
HPRD (in vitro)

		HSPBP1	HSPA9
Gene Name		HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1	heat shock 70kDa protein 9 (mortalin)
Image
Gene Ontology Annotations	Cellular Component		Nucleolus Cytoplasm Mitochondrion Focal Adhesion Mitochondrial Nucleoid Extracellular Vesicular Exosome
	Molecular Function	Enzyme Inhibitor Activity Protein Binding	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Protein Folding Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catalytic Activity	Protein Folding Protein Export From Nucleus Protein Targeting To Mitochondrion Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process
Pathways			Mitochondrial protein import
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: APP HSPA1A HSPA1B HSPA2 HSPA4 HSPA5 HSPA8 HSPA9 LRIF1 NOTCH2NL	15 interactors: APP DNAJA3 DNAJC19 DNLZ FGF1 HSP90B1 HSPBP1 LSM8 MVD NELFB SUMO4 TP53 XPO1 YKT6 YWHAG
Entrez ID		23640	3313
HPRD ID		09991	02770
Ensembl ID		ENSG00000133265	ENSG00000113013
Uniprot IDs		Q9NZL4	P38646
PDB IDs		1XQR 1XQS	3N8E
Enriched GO Terms of Interacting Partners?		Response To Unfolded Protein Protein Refolding Negative Regulation Of Inclusion Body Assembly Regulation Of Inclusion Body Assembly Protein Folding Regulation Of Cellular Response To Heat Cellular Heat Acclimation Cellular Response To Heat Response To Heat Positive Regulation Of Erythrocyte Differentiation MRNA Metabolic Process Response To Temperature Stimulus Regulation Of Protein Ubiquitination Regulation Of Erythrocyte Differentiation Response To Stress Viral Entry Into Host Cell Entry Into Host Cell Response To Organic Substance Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Targeting To Mitochondrion Negative Regulation Of Apoptotic Process Platelet Degranulation Negative Regulation Of Programmed Cell Death Protein Localization To Mitochondrion Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G2/M Transition Of Mitotic Cell Cycle Synaptonemal Complex Disassembly Negative Regulation Of Fibril Organization Regulation Of Protein Folding In Endoplasmic Reticulum Positive Regulation Of Myeloid Cell Differentiation Response To External Stimulus Cellular Protein Metabolic Process Negative Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Oxidative Stress Protein Stabilization Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Establishment Of Localization In Cell Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Protein Ubiquitination Interaction With Host Cerebellum Structural Organization Synaptic Growth At Neuromuscular Junction Secretion By Cell Protein Localization To Organelle Regulation Of Protein Metabolic Process Locomotion Collateral Sprouting In Absence Of Injury Regulation Of Fibril Organization Viral Process	Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Protein Folding Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Localization Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Mitochondrial DNA Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Protein Transport Establishment Of Protein Localization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intracellular Transport Mitochondrial Genome Maintenance Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Catalytic Activity Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Localization Response To Abiotic Stimulus Positive Regulation Of Cellular Metabolic Process Neuromuscular Junction Development Neuron Apoptotic Process Positive Regulation Of Mitochondrion Organization Cytoplasmic Transport Establishment Of Localization In Cell Immune Response Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of Proteolysis Neuron Death T Cell Differentiation In Thymus Negative Regulation Of Cellular Metabolic Process Cellular Protein Localization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Aging Innate Immune Response Membrane Organization Negative Regulation Of Macromitophagy Synaptic Growth At Neuromuscular Junction Actin Rod Assembly Oligodendrocyte Apoptotic Process Regulation Of Mitochondrion Organization Mitochondrion Organization Negative Regulation Of Hydrolase Activity Intracellular Protein Transport
Tagcloud ?		accelerating associates bag biogenesis cftr cochaperone compartments conductance cystic deltaf508 export fibrosis folding hsc70 hsp105 hsp105alpha impairing inform interferes misfolded misfolding multilevel opportunities phe potently relates serves stabilizes super	5q 5q31 cfu collectively colony comprehensively defect del deleted haploinsufficiency haploinsufficient hematopoiesis heterozygous homozygous implicate intrinsic knockdown knockout lethal lymphopoiesis malignancies observe preb progenitors rnai stat5 supporting viable zebrafish
Tagcloud (Difference) ?		accelerating associates bag biogenesis cftr cochaperone compartments conductance cystic deltaf508 export fibrosis folding hsc70 hsp105 hsp105alpha impairing inform interferes misfolded misfolding multilevel opportunities phe potently relates serves stabilizes super	5q 5q31 cfu collectively colony comprehensively defect del deleted haploinsufficiency haploinsufficient hematopoiesis heterozygous homozygous implicate intrinsic knockdown knockout lethal lymphopoiesis malignancies observe preb progenitors rnai stat5 supporting viable zebrafish
Tagcloud (Intersection) ?