HSPBP1 and KRT27

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HSPBP1	KRT27
Description		HSPA (Hsp70) binding protein 1	keratin 27
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum	Cytoplasm Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Enzyme Inhibitor Activity Protein Binding Ubiquitin Protein Ligase Binding Molecular Sequestering Activity	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Protein Folding Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Morphogenesis Of An Epithelium Epithelial Cell Differentiation Hair Follicle Morphogenesis Intermediate Filament Organization
Pathways			Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Thyroid stimulating hormone levels ( 32769997)	Asthma ( 31959851)
Interacting Genes		14 interacting genes: APP CLK1 EFEMP2 HSPA1A HSPA1B HSPA2 HSPA4 HSPA5 HSPA8 HSPA9 KRT27 LRIF1 NOTCH2NLA PTEN	139 interacting genes: AARD ABI2 AMOT ARFIP1 ARHGEF6 ATP6V1D BCAS2 BEX2 BFSP2 C19orf44 C1orf216 C21orf58 CCBE1 CCDC138 CCDC146 CCDC185 CCDC187 CCDC22 CCDC68 CCHCR1 CCNC CEP95 CFAP58 COX5B DPPA3 DTNB DUSP26 EXOC3L1 EXOSC5 FAM107A FAM110A FMNL2 GADD45GIP1 GFAP GNG13 GOLGA1 GPS2 GSTK1 HAPLN2 HDAC4 HGS HOXB9 HSPBP1 ICA1L IGF1R INSR INSRR JOSD1 KANK2 KIAA1217 KLHL38 KRT1 KRT2 KRT20 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT7 KRT71 KRT72 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT81 KRT82 KRT83 KRT85 KRT86 LKAAEAR1 LMNTD2 MATR3 MBD3L2 MID2 MORN4 MOS MTMR9 NDC80 NDUFAF3 NTAQ1 NUP54 NUP58 ODAD3 OIP5 PBX3 PCDHB14 PNN POLL PPP1R18 PRPH PSMC5 RASAL3 RBM41 RCOR3 RNF39 RTP5 RUNX1T1 SCNM1 SDHAF1 SEMA4C SLC22A5 SLIRP SMARCC2 SMARCD1 SMARCE1 SSC5D SSX3 SUFU SUOX TBRG4 TEAD4 TEDC2 TEX28 THAP7 TNNT1 TRAF3IP3 TRIML2 TSKS TTC23 TXLNB TXN2 USHBP1 USP2 VPS37C WASHC3 XRCC4 ZC3H14 ZFYVE26 ZNF3 ZNF580 ZNF581 ZNF669 ZNF80
Entrez ID		23640	342574
HPRD ID		09991	17244
Ensembl ID		ENSG00000133265	ENSG00000171446
Uniprot IDs		Q9NZL4	Q7Z3Y8
PDB IDs		1XQR 1XQS 8X87
Enriched GO Terms of Interacting Partners?		ATP-dependent Protein Folding Chaperone Protein Refolding Protein Folding Chaperone Heat Shock Protein Binding Protein Folding Enzyme Binding Unfolded Protein Binding C3HC4-type RING Finger Domain Binding ATP-dependent Protein Disaggregase Activity Negative Regulation Of Inclusion Body Assembly ATP Hydrolysis Activity G Protein-coupled Receptor Binding Extracellular Exosome Regulation Of Inclusion Body Assembly Response To Unfolded Protein Protein-folding Chaperone Binding Regulation Of Protein Import Blood Microparticle Ubiquitin Protein Ligase Binding ATP Binding Regulation Of Erythrocyte Differentiation Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Negative Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Proteolysis Nucleotide Binding Positive Regulation Of Microtubule Nucleation Cellular Response To Steroid Hormone Stimulus Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Heat Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Misfolded Protein Binding Inclusion Body Regulation Of Microtubule Nucleation Ficolin-1-rich Granule Lumen Receptor Ligand Activity Chaperone-mediated Protein Complex Assembly Regulation Of Mitotic Spindle Assembly Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Stability Negative Regulation Of Cell Population Proliferation Regulation Of Proteolysis Regulation Of Supramolecular Fiber Organization Response To Temperature Stimulus Regulation Of Cellular Component Organization Regulation Of Extrinsic Apoptotic Signaling Pathway	Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Keratinization Keratin Filament Supramolecular Fiber Organization Cytoskeleton Organization Protein Binding Organelle Organization Insulin Receptor Activity Structural Constituent Of Cytoskeleton Insulin Receptor Complex Intermediate Filament Cytoskeleton Structural Molecule Activity Insulin Receptor Substrate Binding Epidermis Development Brahma Complex NpBAF Complex RSC-type Complex NBAF Complex Phosphatidylinositol 3-kinase Binding Nucleosome Disassembly Insulin Binding
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