APEH and LGALS8

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		APEH	LGALS8
Description		acylaminoacyl-peptide hydrolase	galectin 8
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Nuclear Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Space Cytoplasm Cytosol Membrane Cytoplasmic Vesicle
	Molecular Function	RNA Binding Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Omega Peptidase Activity Hydrolase Activity Identical Protein Binding	Integrin Binding Protein Binding Carbohydrate Binding
	Biological Process	Translational Termination Proteolysis Amyloid-beta Metabolic Process	Plasma Cell Differentiation Autophagy T Cell Costimulation Cellular Response To Virus Xenophagy Lymphatic Endothelial Cell Migration
Pathways		Neutrophil degranulation Eukaryotic Translation Termination
Drugs
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Extremely high intelligence ( 29520040) Feeling tense ( 29500382) Feeling worry ( 29500382) Household income ( 31844048) Inflammatory bowel disease ( 28067908) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 21297633 28067908)	Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		7 interacting genes: CEBPA IST1 LGALS8 RUNX1 SHBG TMEM62 UBA5	22 interacting genes: ANXA1 APEH BARD1 CALCOCO2 ERBB2 G3BP1 ITGA3 ITGA4 ITGB1 LRRK2 MEFV MID2 NACC1 NR1D2 NUFIP2 TRIM17 TRIM22 TRIM23 TRIM49 TRIM5 TRIM6 WBP2
Entrez ID		327	3964
HPRD ID		00034	09356
Ensembl ID		ENSG00000164062	ENSG00000116977
Uniprot IDs		P13798	O00214
PDB IDs			2YRO 2YV8 2YXS 3AP4 3AP5 3AP6 3AP7 3AP9 3APB 3OJB 3VKL 3VKM 3VKN 3VKO 4BMB 4BME 4FQZ 4GXL 4HAN 5GZC 5GZD 5GZE 5GZF 5GZG 5T7I 5T7S 5T7T 5T7U 5VWG 6W4Z 6Z6Y 7AEN 7ALS 7P1M 8CM8 8HL9 9FYJ
Enriched GO Terms of Interacting Partners?		Hematopoietic Stem Cell Proliferation Leukocyte Differentiation Stem Cell Proliferation Regulation Of Proteolysis Positive Regulation Of Cell Activation Myeloid Cell Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding UFM1 Activating Enzyme Activity Core-binding Factor Complex Negative Regulation Of Hemopoiesis Regeneration CHOP-C/EBP Complex Response To Vitamin B2 C/EBP Complex Lymphatic Endothelial Cell Migration MIT Domain Binding Cardiac Muscle Tissue Regeneration Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Myeloid Leukocyte Differentiation Regulation Of Cell Activation White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Macroautophagy Androgen Binding Protein K69-linked Ufmylation Protein Homodimerization Activity DNA-binding Transcription Factor Binding Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Plasma Cell Differentiation Positive Regulation Of Proteolysis Response To Phenylpropanoid Xenophagy Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Granulocyte Differentiation Fat Cell Proliferation Regulation Of Cell Development Protein Domain Specific Binding Positive Regulation Of Cell Differentiation Negative Regulation Of Granulocyte Differentiation ESCRT III Complex Disassembly ESCRT Complex Disassembly Ubiquitin-like Modifier Activating Enzyme Activity Protein Ufmylation Transcription Cis-regulatory Region Binding Positive Regulation Of T Cell Activation Peripheral Nervous System Neuron Development Urea Cycle	Ubiquitin Protein Ligase Activity Innate Immune Response Immune System Process Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of Autophagy Immune Response Positive Regulation Of Metabolic Process Defense Response Regulation Of Metabolic Process Response To Other Organism Integrin Alpha3-beta1 Complex Response To External Biotic Stimulus Integrin Alpha4-beta1 Complex Metal Ion Binding Positive Regulation Of Catabolic Process Integrin Complex Positive Regulation Of Macromolecule Metabolic Process Cytoplasm Response To Stress Regulation Of Autophagy Fibronectin Binding Protein Ubiquitination Zinc Ion Binding Regulation Of Protein Localization C-X3-C Chemokine Binding Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Defense Response To Virus Cell-cell Adhesion Mediated By Integrin Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Coreceptor Activity Regulation Of Defense Response Post-translational Protein Modification Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Negative Regulation Of Vasoconstriction Response To Virus Neuromuscular Junction Mesodermal Cell Differentiation Protein-macromolecule Adaptor Activity Focal Adhesion Transferase Activity Regulation Of Rho Protein Signal Transduction Suppression Of Viral Release By Host Positive Regulation Of Immune System Process
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