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FCGR1A and CRKL
Number of citations of the paper that reports this interaction (PubMedID
9820532
)
0
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
FCGR1A
CRKL
Description
Fc gamma receptor Ia
CRK like proto-oncogene, adaptor protein
Image
GO Annotations
Cellular Component
Plasma Membrane
External Side Of Plasma Membrane
Membrane
Clathrin-coated Endocytic Vesicle Membrane
Early Endosome Membrane
Nucleoplasm
Cytoplasm
Cytosol
Neuromuscular Junction
Protein-containing Complex
Synapse
Extrinsic Component Of Postsynaptic Membrane
Molecular Function
Protein Binding
IgG Receptor Activity
High-affinity IgG Receptor Activity
IgG Binding
Phosphotyrosine Residue Binding
RNA Binding
Protein Binding
Receptor Tyrosine Kinase Binding
Signaling Adaptor Activity
Identical Protein Binding
Cadherin Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Biological Process
Antibody-dependent Cellular Cytotoxicity
Positive Regulation Of Type IIa Hypersensitivity
Positive Regulation Of Type III Hypersensitivity
Immune System Process
Receptor-mediated Endocytosis
Phagocytosis, Recognition
Phagocytosis, Engulfment
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Response To Bacterium
Antigen Processing And Presentation Of Exogenous Antigen
Positive Regulation Of Tumor Necrosis Factor Production
Fc-gamma Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Defense Response To Bacterium
Innate Immune Response
Positive Regulation Of Phagocytosis
Regulation Of Immune Response
Regulation Of Cell Growth
Blood Vessel Development
Urogenital System Development
Neuron Migration
B Cell Apoptotic Process
Regulation Of Leukocyte Migration
Outflow Tract Morphogenesis
Lipid Metabolic Process
Enzyme-linked Receptor Protein Signaling Pathway
JNK Cascade
Ras Protein Signal Transduction
Spermatogenesis
Single Fertilization
Pattern Specification Process
Heart Development
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Male Gonad Development
Animal Organ Morphogenesis
Anterior/posterior Pattern Specification
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Dendrite Development
Cell Migration
Hippocampus Development
Cerebral Cortex Development
Establishment Of Cell Polarity
Regulation Of Cell Migration
Regulation Of Cell Adhesion Mediated By Integrin
Positive Regulation Of Rac Protein Signal Transduction
Intracellular Signal Transduction
Helper T Cell Diapedesis
Reelin-mediated Signaling Pathway
Positive Regulation Of MAPK Cascade
Retinoic Acid Receptor Signaling Pathway
Thymus Development
Regulation Of Dendrite Development
T Cell Receptor Signaling Pathway
Parathyroid Gland Development
Cell Chemotaxis
Negative Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Growth Factor Stimulus
Cellular Response To Xenobiotic Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Fibroblast Growth Factor
Endothelin Receptor Signaling Pathway
Acetylcholine Receptor Signaling Pathway
Postsynaptic Specialization Assembly
Cerebellar Neuron Development
Cellular Response To Interleukin-7
Chordate Pharynx Development
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Glial Cell Migration
Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Cranial Skeletal System Development
Regulation Of T Cell Migration
Pathways
Cross-presentation of soluble exogenous antigens (endosomes)
Cross-presentation of soluble exogenous antigens (endosomes)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
FCGR activation
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
Interferon gamma signaling
FCGR3A-mediated IL10 synthesis
Frs2-mediated activation
Frs2-mediated activation
Downstream signal transduction
MET activates RAP1 and RAC1
MET receptor recycling
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
Drugs
Cetuximab
Etanercept
Human immunoglobulin G
Gemtuzumab ozogamicin
Alemtuzumab
Natalizumab
Palivizumab
Daclizumab
Bevacizumab
Porfimer sodium
Catumaxomab
Sarilumab
Trastuzumab deruxtecan
Diseases
GWAS
Mean platelet volume (
32888494
)
Platelet distribution width (
27863252
32888494
)
Interacting Genes
31 interacting genes:
ADIPOQ
APCS
ASGR1
BIK
BMP10
CD163
CLDN19
CLEC7A
CLIC6
CRKL
CRP
FAM3C
FCAR
FCGR3A
HCK
HRG
ITM2A
JAGN1
LAT
LHFPL5
LILRB2
MALL
NINJ1
NRSN1
RPRM
SYK
TNMD
TSPO2
UPK2
VSTM1
VTI1B
78 interacting genes:
ABL1
AOX1
AREL1
ARHGAP32
BCAR1
BCR
BIK
BLK
BLNK
CBL
CBLB
CD34
CRK
DAB1
DOCK2
DOK1
DOK2
EPHB6
EPOR
ERBB2
ERBB3
ETV6
EVL
FCGR1A
GAB1
GAB2
GAREM1
GRB2
GRN
IFNAR1
IGF1R
INPP5D
INSR
IRS4
ITGB1
KHDRBS1
KIDINS220
KIT
LAMA5
LTBP4
LYN
MAP4K1
MAP4K5
MEGF6
MSL1
NEDD9
NOTCH2
PDGFRA
PHC2
PIK3R1
PIK3R2
PLEKHA1
PLSCR1
POLR1D
PPFIBP2
PSMC6
PTPDC1
PTPN11
PXN
RAPGEF1
RPL31
SASH1
SHANK3
SHC1
SOS1
SOS2
STAT5A
STAT5B
SYK
TGFB1I1
TMEM168
TYK2
USP53
WAC
WAS
WIPF1
YES1
YY1
Entrez ID
2209
1399
HPRD ID
00904
03596
Ensembl ID
ENSG00000150337
ENSG00000099942
Uniprot IDs
P12314
P46109
PDB IDs
3RJD
4W4O
4X4M
4ZNE
8DIN
8DIR
8DJ7
2BZX
2BZY
2DBK
2EO3
2LQN
2LQW
Enriched GO Terms of Interacting Partners
?
Immune System Process
Immune Response-regulating Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Defense Response
Inflammatory Response
Immune Effector Process
Regulation Of Immune Response
Leukocyte Degranulation
Regulation Of Immune System Process
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Fc Receptor Signaling Pathway
Immune Response
Acute Inflammatory Response
Positive Regulation Of Superoxide Anion Generation
Regulation Of Superoxide Anion Generation
Positive Regulation Of Immune System Process
Response To External Biotic Stimulus
Regulation Of Cell Population Proliferation
Regulation Of Interleukin-8 Production
Regulation Of Superoxide Metabolic Process
Cellular Response To Molecule Of Fungal Origin
Membrane
Extracellular Region
Fc-gamma Receptor Signaling Pathway
Exocytosis
Response To Molecule Of Fungal Origin
Regulation Of Phagocytosis
Regulated Exocytosis
Plasma Membrane
Acute-phase Response
Leukocyte Migration
Immune Response-activating Cell Surface Receptor Signaling Pathway
Complement Component C1q Complex Binding
Phosphotyrosine Residue Binding
Regulation Of Cell Adhesion Mediated By Integrin
Neutrophil Differentiation
Response To Other Organism
Positive Regulation Of Myeloid Cell Apoptotic Process
Defense Response To Fungus
Cell Activation
Virion Binding
Positive Regulation Of Immune Response
Response To Fungus
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Regulation Of Tumor Necrosis Factor Production
Carbohydrate Binding
Negative Regulation Of Inflammatory Response
Defense Response To Symbiont
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
SH3 Domain Binding
Phosphotyrosine Residue Binding
Intracellular Signal Transduction
Protein Tyrosine Kinase Activity
Immune System Process
Insulin Receptor Signaling Pathway
Cell Activation
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Immune Response
Leukocyte Activation
Immune Effector Process
ERBB Signaling Pathway
B Cell Receptor Signaling Pathway
Lymphocyte Activation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Intracellular Signaling Cassette
Cytosol
Regulation Of Immune System Process
B Cell Differentiation
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Immune System Process
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
B Cell Activation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Positive Regulation Of MAPK Cascade
Cell Migration
Cellular Response To Growth Factor Stimulus
Plasma Membrane
Regulation Of Cell Activation
Immune Response-regulating Signaling Pathway
Protein Tyrosine Kinase Binding
Positive Regulation Of Cellular Component Organization
Regulation Of MAPK Cascade
Protein Kinase Activity
Positive Regulation Of Immune Response
Regulation Of Multicellular Organismal Process
Growth Hormone Receptor Signaling Pathway
T Cell Activation
Regulation Of Signaling
Regulation Of Cell Communication
Response To Growth Factor
Regulation Of Multicellular Organismal Development
Ephrin Receptor Binding
Regulation Of Leukocyte Proliferation
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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