FCGR1A and MALL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FCGR1A	MALL
Description		Fc gamma receptor Ia	mal, T cell differentiation protein like
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane	Golgi Membrane Plasma Membrane Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft
	Molecular Function	Protein Binding IgG Receptor Activity High-affinity IgG Receptor Activity IgG Binding	Protein Binding Structural Constituent Of Myelin Sheath
	Biological Process	Antibody-dependent Cellular Cytotoxicity Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Type III Hypersensitivity Immune System Process Receptor-mediated Endocytosis Phagocytosis, Recognition Phagocytosis, Engulfment Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To Bacterium Antigen Processing And Presentation Of Exogenous Antigen Positive Regulation Of Tumor Necrosis Factor Production Fc-gamma Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Defense Response To Bacterium Innate Immune Response Positive Regulation Of Phagocytosis Regulation Of Immune Response	Myelination Cholesterol Homeostasis
Pathways		Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes) Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Interferon gamma signaling FCGR3A-mediated IL10 synthesis
Drugs		Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Natalizumab Palivizumab Daclizumab Bevacizumab Porfimer sodium Catumaxomab Sarilumab Trastuzumab deruxtecan
Diseases
GWAS
Interacting Genes		31 interacting genes: ADIPOQ APCS ASGR1 BIK BMP10 CD163 CLDN19 CLEC7A CLIC6 CRKL CRP FAM3C FCAR FCGR3A HCK HRG ITM2A JAGN1 LAT LHFPL5 LILRB2 MALL NINJ1 NRSN1 RPRM SYK TNMD TSPO2 UPK2 VSTM1 VTI1B	69 interacting genes: AMIGO1 AQP6 ARL13B ATP5PF BEST2 BNIP3 BNIP3L BRI3 BSCL2 CAV1 CAV2 CD79A CLDN7 CLDN9 CLEC10A CLEC12B CLEC14A CPLX4 CREB3 CREB3L1 CRHR2 CTLA4 DAGLA DCBLD2 ELOVL2 ELOVL4 EMP1 ERGIC3 EVI2A FCGR1A FFAR2 FNDC9 GGT7 GJA8 GPA33 IL7R KASH5 KLRC1 LDLRAD1 LEPROTL1 LMNA MANBAL MCEMP1 MS4A12 MSR1 MUC1 OPRM1 PGRMC2 PLA2G2E RETREG3 RNF185 SIGLEC6 SIT1 SLC10A1 SLC10A6 SLC18A1 SLC35H1 STMN4 STX1A SYNE4 SYT2 TMEM139 TMEM182 TMEM248 TMEM31 TMEM80 TMX2 UBE2I ZP3
Entrez ID		2209	7851
HPRD ID		00904	15997
Ensembl ID		ENSG00000150337	ENSG00000144063
Uniprot IDs		P12314	Q13021
PDB IDs		3RJD 4W4O 4X4M 4ZNE 8DIN 8DIR 8DJ7
Enriched GO Terms of Interacting Partners?		Immune System Process Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Defense Response Inflammatory Response Immune Effector Process Regulation Of Immune Response Leukocyte Degranulation Regulation Of Immune System Process Positive Regulation Of Monocyte Chemotactic Protein-1 Production Fc Receptor Signaling Pathway Immune Response Acute Inflammatory Response Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Positive Regulation Of Immune System Process Response To External Biotic Stimulus Regulation Of Cell Population Proliferation Regulation Of Interleukin-8 Production Regulation Of Superoxide Metabolic Process Cellular Response To Molecule Of Fungal Origin Membrane Extracellular Region Fc-gamma Receptor Signaling Pathway Exocytosis Response To Molecule Of Fungal Origin Regulation Of Phagocytosis Regulated Exocytosis Plasma Membrane Acute-phase Response Leukocyte Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Complement Component C1q Complex Binding Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Mediated By Integrin Neutrophil Differentiation Response To Other Organism Positive Regulation Of Myeloid Cell Apoptotic Process Defense Response To Fungus Cell Activation Virion Binding Positive Regulation Of Immune Response Response To Fungus Positive Regulation Of Interleukin-8 Production Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Tumor Necrosis Factor Production Carbohydrate Binding Negative Regulation Of Inflammatory Response Defense Response To Symbiont	Membrane Protein Binding Plasma Membrane Caveolar Macromolecular Signaling Complex Nuclear Envelope Adaptive Immune Response Natural Killer Cell Inhibitory Signaling Pathway Endoplasmic Reticulum-autophagosome Adaptor Activity Carbohydrate Binding External Side Of Plasma Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Acute Inflammatory Response Bile Acid:sodium Symporter Activity Membrane Organization Immune Response-regulating Signaling Pathway Lipid Storage Positive Regulation Of Hypersensitivity Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Substrate Localization To Autophagosome Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Fatty Acid Elongation, Saturated Fatty Acid Mitochondrial Outer Membrane Permeabilization Caveola Assembly Organic Hydroxy Compound Transport Regulation Of Response To Endoplasmic Reticulum Stress Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Regulation Of Calcium Ion-dependent Exocytosis Mitochondrial Protein Catabolic Process Plasma Membrane Raft Assembly Negative Regulation Of T Cell Mediated Cytotoxicity Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Acute Inflammatory Response Immune Response-inhibiting Signal Transduction
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