FCGR1A and FCAR

Number of citations of the paper that reports this interaction (PubMedID 8530370)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		FCGR1A	FCAR
Description		Fc gamma receptor Ia	Fc alpha receptor
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane	Extracellular Region Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding IgG Receptor Activity High-affinity IgG Receptor Activity IgG Binding	IgA Receptor Activity IgA Binding
	Biological Process	Antibody-dependent Cellular Cytotoxicity Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Type III Hypersensitivity Immune System Process Receptor-mediated Endocytosis Phagocytosis, Recognition Phagocytosis, Engulfment Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To Bacterium Antigen Processing And Presentation Of Exogenous Antigen Positive Regulation Of Tumor Necrosis Factor Production Fc-gamma Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Defense Response To Bacterium Innate Immune Response Positive Regulation Of Phagocytosis Regulation Of Immune Response	Neutrophil Mediated Immunity Immune Response-regulating Signaling Pathway Immune Response Positive Regulation Of Neutrophil Apoptotic Process Cellular Response To Interferon-alpha Fc Receptor Signaling Pathway Neutrophil Activation Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Pathways		Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes) Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Interferon gamma signaling FCGR3A-mediated IL10 synthesis	Neutrophil degranulation
Drugs		Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Natalizumab Palivizumab Daclizumab Bevacizumab Porfimer sodium Catumaxomab Sarilumab Trastuzumab deruxtecan
Diseases
GWAS			Ulcerative colitis ( 28067908)
Interacting Genes		31 interacting genes: ADIPOQ APCS ASGR1 BIK BMP10 CD163 CLDN19 CLEC7A CLIC6 CRKL CRP FAM3C FCAR FCGR3A HCK HRG ITM2A JAGN1 LAT LHFPL5 LILRB2 MALL NINJ1 NRSN1 RPRM SYK TNMD TSPO2 UPK2 VSTM1 VTI1B	6 interacting genes: CD79A FCGR1A LYN OSCAR PILRA PPP2CA
Entrez ID		2209	2204
HPRD ID		00904	00914
Ensembl ID		ENSG00000150337	ENSG00000186431
Uniprot IDs		P12314	A0A1P8A760 P24071
PDB IDs		3RJD 4W4O 4X4M 4ZNE 8DIN 8DIR 8DJ7	1OVZ 1OW0 1UCT 8SKU
Enriched GO Terms of Interacting Partners?		Immune System Process Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Defense Response Inflammatory Response Immune Effector Process Regulation Of Immune Response Leukocyte Degranulation Regulation Of Immune System Process Positive Regulation Of Monocyte Chemotactic Protein-1 Production Fc Receptor Signaling Pathway Immune Response Acute Inflammatory Response Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Positive Regulation Of Immune System Process Response To External Biotic Stimulus Regulation Of Cell Population Proliferation Regulation Of Interleukin-8 Production Regulation Of Superoxide Metabolic Process Cellular Response To Molecule Of Fungal Origin Membrane Extracellular Region Fc-gamma Receptor Signaling Pathway Exocytosis Response To Molecule Of Fungal Origin Regulation Of Phagocytosis Regulated Exocytosis Plasma Membrane Acute-phase Response Leukocyte Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Complement Component C1q Complex Binding Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Mediated By Integrin Neutrophil Differentiation Response To Other Organism Positive Regulation Of Myeloid Cell Apoptotic Process Defense Response To Fungus Cell Activation Virion Binding Positive Regulation Of Immune Response Response To Fungus Positive Regulation Of Interleukin-8 Production Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Tumor Necrosis Factor Production Carbohydrate Binding Negative Regulation Of Inflammatory Response Defense Response To Symbiont	Immune Response-regulating Signaling Pathway Adaptive Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Membrane Raft B Cell Proliferation Fc-gamma Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Immune Response Fc Receptor Signaling Pathway Leukocyte Differentiation Lymphocyte Homeostasis Signal Transduction Plasma Membrane High-affinity IgG Receptor Activity Leukocyte Homeostasis RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune Response IgM B Cell Receptor Complex Lymphocyte Proliferation Leukocyte Proliferation Mononuclear Cell Proliferation Immune System Process Regulation Of Immune System Process B Cell Receptor Complex Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Type III Hypersensitivity Platelet Degranulation Histamine Secretion By Mast Cell Negative Regulation Of Mast Cell Proliferation Myeloid Leukocyte Differentiation Fc Receptor Mediated Inhibitory Signaling Pathway Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Postsynaptic Specialization, Intracellular Component Positive Regulation Of Mast Cell Proliferation Integrin Alpha2-beta1 Complex Tolerance Induction To Self Antigen Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Phosphate Metabolic Process Positive Regulation Of Dendritic Cell Apoptotic Process Homeostasis Of Number Of Cells Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Collagen Receptor Activity B Cell Activation IgG Receptor Activity Regulation Of Oligodendrocyte Progenitor Proliferation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
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