FCGR1A and FCAR

Number of citations of the paper that reports this interaction (PMID 12524384)
58

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		FCGR1A	FCAR
Gene Name		Fc fragment of IgG, high affinity Ia, receptor (CD64)	Fc fragment of IgA, receptor for
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Receptor Signaling Protein Activity Protein Binding IgG Binding	IgA Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Phagocytosis, Engulfment Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Interferon-gamma-mediated Signaling Pathway	Immune Response
Pathways		Interferon gamma signaling Interferon Signaling Cross-presentation of soluble exogenous antigens (endosomes) Role of phospholipids in phagocytosis Cytokine Signaling in Immune system Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Regulation of actin dynamics for phagocytic cup formation Adaptive Immune System Innate Immune System
Drugs		Cetuximab Etanercept Intravenous Immunoglobulin Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab Porfimer Methyl aminolevulinate
Diseases
GWAS
Protein-Protein Interactions		10 interactors: APCS CRKL CRP FCAR FCGR3A HCK HRG LAT LILRB2 SYK	6 interactors: CD79A FCGR1A LYN OSCAR PILRA PPP2CA
Entrez ID		2209	2204
HPRD ID		00904	00914
Ensembl ID		ENSG00000150337	ENSG00000186431
Uniprot IDs		P12314	P24071
PDB IDs		3RJD	1OVZ 1OW0 1UCT
Enriched GO Terms of Interacting Partners?		Immune Response Regulation Of Immune System Process Defense Response Immune System Process Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Stress Inflammatory Response Immune Response-regulating Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Other Organism Response To Biotic Stimulus Exocytosis Vesicle-mediated Transport Innate Immune Response Regulation Of Superoxide Anion Generation Integrin-mediated Signaling Pathway Regulation Of Wound Healing Response To Stimulus Regulation Of Cell Activation Response To Bacterium Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Secretion By Cell Defense Response To Bacterium Platelet Activation Positive Regulation Of Tissue Remodeling Regulation Of Platelet Activation Wound Healing Regulation Of Cell Adhesion Secretion Endocytosis Peptidyl-tyrosine Autophosphorylation Acute-phase Response Regulation Of Cell Adhesion Mediated By Integrin Response To Fungus Response To Wounding Leukocyte Degranulation Response To Organic Substance Regulation Of T Cell Activation Regulated Secretory Pathway Regulation Of Phagocytosis Negative Regulation Of Wound Healing Defense Response To Gram-positive Bacterium Regulation Of Tissue Remodeling	Immune Response-activating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Negative Regulation Of MAP Kinase Activity Regulation Of JAK-STAT Cascade Positive Regulation Of Immune Response Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Mast Cell Proliferation Negative Regulation Of Protein Serine/threonine Kinase Activity Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of MAPK Cascade Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Signal Transduction Tolerance Induction To Self Antigen Fc Receptor Mediated Inhibitory Signaling Pathway Positive Regulation Of Dendritic Cell Apoptotic Process Regulation Of Peptidyl-tyrosine Phosphorylation Signaling Negative Regulation Of Protein Kinase Activity Cell Communication Negative Regulation Of Kinase Activity Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune Response-inhibiting Signal Transduction Phagocytosis Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of MAP Kinase Activity Regulation Of Immune System Process Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Tolerance Induction Positive Regulation Of Mast Cell Proliferation Negative Regulation Of Transferase Activity Positive Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Protein Phosphorylation Cellular Response To Stimulus Leukocyte Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Mitotic Nuclear Envelope Reassembly Protein Heterotrimerization Histamine Secretion By Mast Cell Nuclear Envelope Reassembly
Tagcloud ?		ababa addis apart aucs bcl2 blr1 bpi ccl19 colour contacts dcrt discriminatory foxp3 fpr1 household il4d2 il7r latently ltbi ltf marco mlpa mmp9 multiplex qft smear tb tgfb1 uninfected	anca antineutrophil assembled cd11b confocal degranulation engagement extracellcular fcgr3b fcr fcrs genetics granulomatosis haplotype iga igg illumina mucosal multicenter na1 na2 neutrophil polyangiitis pyrosequencing tagging taqman unappreciated vasculitis wegener
Tagcloud (Difference) ?		ababa addis apart aucs bcl2 blr1 bpi ccl19 colour contacts dcrt discriminatory foxp3 fpr1 household il4d2 il7r latently ltbi ltf marco mlpa mmp9 multiplex qft smear tb tgfb1 uninfected	anca antineutrophil assembled cd11b confocal degranulation engagement extracellcular fcgr3b fcr fcrs genetics granulomatosis haplotype iga igg illumina mucosal multicenter na1 na2 neutrophil polyangiitis pyrosequencing tagging taqman unappreciated vasculitis wegener
Tagcloud (Intersection) ?