HNRNPA1 and KHSRP

Number of citations of the paper that reports this interaction (PMID 11003644)
108

Data Source:
BioGRID (pull down, affinity chromatography technology)

		HNRNPA1	KHSRP
Gene Name		heterogeneous nuclear ribonucleoprotein A1	KH-type splicing regulatory protein
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex Cytoplasm Membrane Ribonucleoprotein Complex Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome	Nucleoplasm Cytosol Cytoplasmic Stress Granule Membrane
	Molecular Function	Nucleotide Binding Single-stranded DNA Binding RNA Binding Single-stranded RNA Binding Protein Binding Poly(A) RNA Binding	DNA Binding MRNA Binding Poly(A) RNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Export From Nucleus RNA Splicing Gene Expression Viral Process MRNA Transport Nuclear Export Nuclear Import	RNA Splicing, Via Transesterification Reactions Transcription, DNA-templated Regulation Of Transcription, DNA-templated MRNA Processing MRNA Catabolic Process RNA Splicing Gene Expression MRNA Transport Regulation Of MiRNA Metabolic Process
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA ATF4 activates genes PERK regulates gene expression Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		32 interactors: ABHD16A APP ERG FEN1 HIPK3 HIST3H3 HMGA1 HNRNPH3 KHSRP NFKBIA NR0B2 NR3C1 PABPN1 PHYHIP PPIL1 PRKDC PRMT1 PRMT2 PRMT3 PRRC2A RNF14 RPL21 SAFB SREK1 SRPK1 SUFU TFEC TNPO1 TRA2B TTF2 XRN1 YWHAQ	12 interactors: A1CF APBB1 BACE1 EXOSC2 EXOSC3 GADD45A GSK3B HNRNPA1 HNRNPH1 PARN PTBP2 STK3
Entrez ID		3178	8570
HPRD ID		01242	10350
Ensembl ID		ENSG00000135486	ENSG00000088247
Uniprot IDs		P09651	Q92945
PDB IDs		1HA1 1L3K 1PGZ 1PO6 1U1K 1U1L 1U1M 1U1N 1U1O 1U1P 1U1Q 1U1R 1UP1 2H4M 2LYV 2UP1	2HH2 2HH3 2JVZ 2OPU 2OPV 4B8T
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process MRNA Processing Regulation Of Gene Expression Nitrogen Compound Metabolic Process RNA Splicing Regulation Of Nitrogen Compound Metabolic Process RNA Processing Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Chromosome Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Peptidyl-arginine N-methylation Positive Regulation Of Gene Expression Histone Arginine Methylation Peptidyl-arginine Methylation Intracellular Receptor Signaling Pathway Cellular Metabolic Process RNA Splicing, Via Transesterification Reactions RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Metabolic Process Chromatin Organization Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process RNA Catabolic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Telomere Maintenance Peptidyl-amino Acid Modification Cellular Macromolecule Biosynthetic Process Regulation Of MRNA Processing MRNA Splicing, Via Spliceosome Aromatic Compound Catabolic Process Macromolecule Biosynthetic Process Regulation Of Androgen Receptor Signaling Pathway Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of Nucleic Acid-templated Transcription	MRNA Metabolic Process RNA Processing Intracellular MRNA Localization Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Cellular Nitrogen Compound Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' RNA Localization Nitrogen Compound Metabolic Process MRNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process SnoRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nucleobase-containing Compound Metabolic Process Nuclear MRNA Surveillance RRNA 3'-end Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Surveillance RRNA Catabolic Process Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis RNA Metabolic Process Maturation Of 5.8S RRNA Cellular Metabolic Process Nuclear-transcribed MRNA Catabolic Process Gene Expression MRNA Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Catabolic Process SnRNA Processing Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death SnRNA Metabolic Process Regulation Of Growth Positive Regulation Of Cell Death MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleic Acid Phosphodiester Bond Hydrolysis Ribonucleoprotein Complex Biogenesis Positive Regulation Of Protein Binding Negative Regulation Of Thymidylate Synthase Biosynthetic Process
Tagcloud ?		amyotrophic autosomal carriers coding conserved equivocal et ewsr1 exons export familial frontotemporal fus genotyped genotyping lobar nes neurodegeneration pathogenicity r471c relatives sequenced subject substitution taf15 tardbp tdp43 tremor	apparently bax biotinylated deoxynucleotidyl distributed dutp homology immunofluorescent importantly interference labeling mainly manganese manganism micronutrient mitogen mn multifunctional neurological neuronal neurotoxicity nick pc12 splicing striatal striatum transferase tunel upregulation
Tagcloud (Difference) ?		amyotrophic autosomal carriers coding conserved equivocal et ewsr1 exons export familial frontotemporal fus genotyped genotyping lobar nes neurodegeneration pathogenicity r471c relatives sequenced subject substitution taf15 tardbp tdp43 tremor	apparently bax biotinylated deoxynucleotidyl distributed dutp homology immunofluorescent importantly interference labeling mainly manganese manganism micronutrient mitogen mn multifunctional neurological neuronal neurotoxicity nick pc12 splicing striatal striatum transferase tunel upregulation
Tagcloud (Intersection) ?