CD74 and HLA-DQA1

Number of citations of the paper that reports this interaction (PubMedID 25241761)
0

Data Source:
BioGRID (imaging technique)
HPRD (in vivo)

		CD74	HLA-DQA1
Description		CD74 molecule	major histocompatibility complex, class II, DQ alpha 1
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Vacuole Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Protein-containing Complex Macrophage Migration Inhibitory Factor Receptor Complex NOS2-CD74 Complex MHC Class II Protein Complex Lysosomal Lumen Extracellular Exosome Lumenal Side Of Endoplasmic Reticulum Membrane	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Amyloid-beta Binding Cytokine Receptor Activity Protein Binding Cytokine Binding MHC Class II Protein Complex Binding Macrophage Migration Inhibitory Factor Binding MHC Class II Protein Binding CD4 Receptor Binding MHC Class II Protein Binding, Via Antigen Binding Groove Identical Protein Binding Protein Folding Chaperone Nitric-oxide Synthase Binding	Protein Binding MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Prostaglandin Biosynthetic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine-mediated Signaling Pathway Adaptive Immune Response T Cell Activation Involved In Immune Response Immune System Process Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Peptide Secretion Positive Regulation Of Type 2 Immune Response Negative Regulation Of Mature B Cell Apoptotic Process Protein Folding Intracellular Protein Transport Defense Response Immune Response Positive Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Kinase Activity Response To Type II Interferon Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator T Cell Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Negative Regulation Of T Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of DNA-templated Transcription Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Fibroblast Proliferation Protein Stabilization Positive Regulation Of Macrophage Cytokine Production Protein-containing Complex Assembly Protein Trimerization Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation
Pathways		Cell surface interactions at the vascular wall MHC class II antigen presentation Developmental Lineage of Pancreatic Ductal Cells	Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling
Drugs
Diseases			Systemic lupus erythematosus Graves' disease Hashimoto's thyroiditis Dilated cardiomyopathy (DCM) Type I diabetes mellitus
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Post bronchodilator FEV1/FVC ratio ( 26634245)	A body shape index ( 34021172) Adult asthma ( 30578877) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alanine aminotransferase levels ( 33547301) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Allergy ( 27182965) Anti-Epstein-Barr virus nuclear antigen (EBNA) IgG levels ( 32737300) Anti-polyomavirus 2 IgG seropositivity ( 33204752) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Apolipoprotein B levels ( 32203549) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 33768542) Aspartate aminotransferase levels ( 33339817 33547301) Asthma ( 23181788 27182965 29273806 30929738 31361310 31619474 31959851 32296059 34103634) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Autism spectrum disorder or schizophrenia ( 28540026) Autoimmune hepatitis in primary sclerosing cholangitis ( 28779025) Autoimmune hepatitis type-1 ( 24768677) Autoimmune thyroid disease ( 32581359) Basal cell carcinoma ( 31174203 33549134) Body mass index ( 28892062) C-reactive protein levels ( 30388399) Celiac disease ( 17558408 20190752) Cervical cancer ( 23482656 28806749) Cervical intraepithelial neoplasia grade 3 ( 33794208) Cervical intraepithelial neoplasia grade 3 and invasive cervical cancer ( 33794208) Childhood asthma with severe exacerbations ( 33328473) Childhood ear infection ( 27182965 28928442) Childhood steroid-sensitive nephrotic syndrome ( 29903748 31263063) Chronic hepatitis C infection ( 24376798) Chronic lymphocytic leukemia ( 21131588) Chronic obstructive pulmonary disease ( 33909500) Chronic rhinosinusitis ( 30643255) Composite immunoglobulin trait (IgA x IgG x IgM) ( 28628107) Creatinine levels ( 29403010) Crohn's disease ( 23266558 23850713 26891255) Cutaneous lupus erythematosus ( 25827949) Cutaneous squamous cell carcinoma ( 32041948) Drug-induced liver injury (flucloxacillin) ( 30661239) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494) Epstein Barr virus nuclear antigen 1 IgG levels ( 26819262 29868224) Epstein Barr virus nuclear antigen 1 IgG seropositivity ( 29868224) Epstein-Barr virus EBNA-1 antibody levels ( 33204752) Epstein-Barr virus immune response (multivariate analysis) ( 29868224) Epstein-Barr virus VCA p18 antibody levels ( 33204752) Epstein-Barr virus ZEBRA antibody levels ( 33204752) Estimated glomerular filtration rate ( 30604766) Factor VIII levels ( 30586737) Giant cell arteritis ( 25817017 28041642) Glomerular filtration rate ( 29403010) Granulocyte percentage of myeloid white cells ( 27863252) Hand grip strength ( 29691431) Hematocrit ( 27863252) Hemoglobin levels ( 32327693) Hepatocellular carcinoma ( 22807686) High density lipoprotein cholesterol levels ( 29403010) Hip circumference adjusted for BMI ( 34021172) Human herpes virus 6 IE1A antibody levels ( 33204752) Human herpes virus 7 U14 antibody levels ( 33204752) Hypothyroidism ( 22493691 27182965) Idiopathic membranous nephropathy ( 21323541) IgA nephropathy ( 25305756 26028593) Immune response to anthrax vaccine ( 22658931) Immunoglobulin A vasculitis ( 28698626) Immunoglobulin G index levels in multiple sclerosis ( 25616667) Inflammatory bowel disease ( 18758464 28008999 28067908) Intraocular pressure ( 29785010) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Keratinocyte cancer (MTAG) ( 31174203) Late-onset myasthenia gravis ( 26562150) Leishmaniasis (visceral) ( 23291585) Leprosy ( 32421744) Low density lipoprotein cholesterol levels ( 32154731) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730 31577861) Lymphocyte count ( 29403010 32888494) Lymphocyte percentage of white cells ( 32888494) Lymphoma ( 23349640) Mean corpuscular hemoglobin ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Membranous nephropathy ( 27333618) Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430) Monocyte percentage of white cells ( 32888494) Multiple sclerosis (OCB status) ( 23472185) Myasthenia gravis ( 25643325) Myositis ( 26291516) Nasal polyps ( 30643255) Nephropathy ( 21399633) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Neuromyelitis optica ( 29769526 32792643) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Oligoclonal band status in multiple sclerosis ( 25616667) Oropharynx cancer ( 32276964) Parental lifespan ( 29030599 30642433) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Parkinson's disease ( 27182965 28892059) Peanut allergy ( 25710614) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Plantar warts ( 28928442) Pneumonia ( 28928442) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 23603763) Prostate cancer ( 23535732) Red blood cell count ( 27863252) Refractive error ( 32231278) Response to hepatitis B vaccine ( 29534301) Response to interferon beta therapy ( 21502966) Rheumatoid arthritis ( 18668548 23918589) Rheumatoid arthritis (ACPA-negative) ( 24532677) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Scarlet fever ( 28928442) Schizophrenia ( 19571809 23212062) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Serum alkaline phosphatase levels ( 33547301) Severe autoimmune type 2 diabetes ( 34737425) Shingles ( 28928442) Sjögren's syndrome ( 24097066 24097067 28076899) Small cell lung carcinoma ( 28604730) Squamous cell carcinoma ( 26829030 31174203) Squamous cell lung carcinoma ( 28604730) Strep throat ( 28928442) Systemic lupus erythematosus ( 18204098 21408207 24871463 26316170 26606652 32771030) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533) Thyroid stimulating hormone levels ( 32769997) Tonsillectomy ( 28928442) Total bilirubin levels ( 29403010) Triglyceride levels ( 32203549) Tuberculosis ( 28928442) Type 1 diabetes (age at diagnosis) ( 33179336) Type 2 diabetes ( 28566273) Ulcerative colitis ( 19122664 21297633 23128233 23511034 24837172 26278503 28008999 28067908) Urate levels ( 31578528) Varicella zoster virus glycoproteins E and I antibody levels ( 33204752) Vitiligo ( 20410501 27723757) Vogt-Koyanagi-Harada syndrome ( 25108386) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		45 interacting genes: APP BET1 C14orf180 CCR1 CD1D CD44 CLDN19 CLEC7A CMTM7 CTSF CTSL DSCR9 EDDM3B ERG28 FDFT1 FXYD6 HADHA HLA-DMA HLA-DMB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRA LAMTOR5 LPAR3 MAP3K1 MIF PGA4 PLP1 PLPP4 POMGNT1 PTCH1 RTP2 SEC22A SERP1 SLC35B1 SMIM1 TEX11 TMEM120B TMEM243 TMEM254 TMEM60 TMEM97 UPK2	9 interacting genes: APLP1 CD74 CDK7 HLA-DQB1 IKBKG LRIF1 SH3GL2 TLE1 UNC119
Entrez ID		972	3117
HPRD ID		00825	06765
Ensembl ID		ENSG00000019582	ENSG00000196735
Uniprot IDs		P04233	A0A173ADG5 A0A346FLH4 A0A649ZVH5 L8E864 P01909 Q5Y7C6 Q5Y7H0 Q8MH44
PDB IDs		1A6A 1ICF 1IIE 1L3H 1MUJ 3PDO 3PGC 3PGD 3QXA 3QXD 4AEN 4AH2 4X5W 5KSU 5KSV 7YX9 7YXB 7Z0Q 8VRW 8VSJ 8VSP 9CYL 9CYM	1JK8 1S9V 1UVQ 2NNA 3PL6 4D8P 4GG6 4OZF 4OZG 4OZH 4OZI 5KS9 5KSA 5KSB 5KSU 5KSV 6MFF 6MFG 6U3M 6U3N 6XP6 7SG0 7SG1 7SG2 8VSP 8W83 8W84 8W85 8W86
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Exogenous Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation MHC Class II Protein Complex Binding Peptide Antigen Binding Lysosome Positive Regulation Of Cell Activation MHC Class II Receptor Activity Late Endosome Membrane Membrane Positive Regulation Of Lymphocyte Activation Lumenal Side Of Endoplasmic Reticulum Membrane Endocytic Vesicle Membrane Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Transport Vesicle Membrane Positive Regulation Of T Cell Activation Trans-Golgi Network Membrane Lysosomal Membrane ER To Golgi Transport Vesicle Membrane Regulation Of Leukocyte Cell-cell Adhesion Cell Surface Regulation Of Cell Activation Regulation Of Lymphocyte Activation Adaptive Immune Response Clathrin-coated Endocytic Vesicle Membrane Positive Regulation Of Immune System Process Immune System Process Endoplasmic Reticulum Regulation Of Immune Response Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Immune Response Regulation Of T Cell Activation Immune Response Endoplasmic Reticulum Membrane Positive Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Positive Regulation Of Type II Interferon Production Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Leukocyte Proliferation Plasma Membrane Endosome	MHC Class II Protein Complex Clathrin-coated Endocytic Vesicle Membrane MHC Class II Protein Complex Binding Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Transport Vesicle Membrane ER To Golgi Transport Vesicle Membrane Antigen Processing And Presentation Of Peptide Antigen Peptide Antigen Assembly With MHC Class II Protein Complex Endocytic Vesicle Membrane Antigen Processing And Presentation Trans-Golgi Network Membrane Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Peptide Antigen Binding Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Immune Response Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion MHC Class II Receptor Activity Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Immune Response Adaptive Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Golgi Membrane Regulation Of Cell Activation Lysosomal Membrane Antigen Receptor-mediated Signaling Pathway Late Endosome Membrane Endosome Protein-containing Complex Assembly Regulation Of Cell Adhesion Lysosome Alpha-2B Adrenergic Receptor Binding MHC Class II Protein Binding, Via Antigen Binding Groove Protein-containing Complex Organization NOS2-CD74 Complex Macrophage Migration Inhibitory Factor Signaling Pathway RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity Regulation Of Macromolecule Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?