CD74 and HLA-DQB1

Number of citations of the paper that reports this interaction (PMID 16242130)
2

Data Source:
HPRD (in vivo)

		CD74	HLA-DQB1
Gene Name		CD74 molecule, major histocompatibility complex, class II invariant chain	major histocompatibility complex, class II, DQ beta 1
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Intracellular Lysosomal Membrane Multivesicular Body Vacuole Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Integral Component Of Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Macrophage Migration Inhibitory Factor Receptor Complex NOS2-CD74 Complex MHC Class II Protein Complex Lysosomal Lumen Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Golgi Membrane Lysosomal Membrane Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Beta-amyloid Binding Cytokine Receptor Activity Protein Binding Cytokine Binding MHC Class II Protein Complex Binding Macrophage Migration Inhibitory Factor Binding MHC Class II Protein Binding MHC Class II Protein Binding, Via Antigen Binding Groove Identical Protein Binding Protein Binding Involved In Protein Folding Nitric-oxide Synthase Binding	MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Activation Of MAPK Activity Prostaglandin Biosynthetic Process Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Peptide Secretion Positive Regulation Of Type 2 Immune Response Negative Regulation Of Mature B Cell Apoptotic Process Protein Complex Assembly Intracellular Protein Transport Defense Response Signal Transduction Cell Proliferation Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of B Cell Proliferation Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator T Cell Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Negative Regulation Of T Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Chaperone Mediated Protein Folding Requiring Cofactor Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Humoral Immune Response Mediated By Circulating Immunoglobulin Immune Response Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway
Pathways		MHC class II antigen presentation Adaptive Immune System	Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS			Asthma ( 21804548) Celiac disease ( 20190752) Crohn's disease ( 23266558) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Follicular lymphoma ( 20639881 21533074) Hepatitis B ( 21750111) HPV seropositivity ( 21896673) Hypothyroidism ( 22493691) IgE levels ( 23146381) Knee osteoarthritis ( 20305777) Lymphoma ( 23349640) Multiple sclerosis ( 20453840) Multiple sclerosis (OCB status) ( 23472185) Nephropathy ( 21399633) Nodular sclerosis Hodgkin lymphoma ( 22086417) Primary biliary cirrhosis ( 19458352 20639880) Prostate cancer ( 23535732) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Systemic sclerosis ( 20383147 21779181) Ulcerative colitis ( 23128233 19122664)
Protein-Protein Interactions		14 interactors: APP CD1D CD44 CTSF CTSL HADHA HLA-DMA HLA-DMB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRA MIF	4 interactors: CD4 CD74 HLA-DQA2 INS
Entrez ID		972	3119
HPRD ID		00825	05054
Ensembl ID		ENSG00000019582	ENSG00000179344
Uniprot IDs		P04233	P01920 Q5SU54 Q5Y7A9 Q5Y7D3 Q5Y7D6
PDB IDs		1A6A 1ICF 1IIE 1L3H 1MUJ 3PDO 3PGC 3PGD 3QXA 3QXD 4AEN 4AH2	1JK8 1NBN 1S9V 1UVQ 2NNA 4GG6
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Positive Regulation Of Homotypic Cell-cell Adhesion Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Activation Immune Response Positive Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Immune Response Immune System Process Regulation Of Cell Activation Regulation Of T Cell Activation Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Cell Adhesion Interferon-gamma-mediated Signaling Pathway Cellular Response To Interferon-gamma Regulation Of Immune System Process Defense Response Response To Interferon-gamma T Cell Costimulation Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly T Cell Receptor Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Antigen Receptor-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of T Cell Proliferation Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of T Cell Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Cytokine Response To Organic Substance Response To Stress Response To Stimulus Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To Organic Substance Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Cell Proliferation	Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Immune System Process Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Defense Response Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process T Cell Selection Lymphocyte Activation Positive Regulation Of Protein Kinase Activity Regulation Of Cell Activation Leukocyte Activation Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Single Organismal Cell-cell Adhesion Regulation Of Cytokine Production Positive Regulation Of Transferase Activity T Cell Costimulation Regulation Of Cell Adhesion Immune System Process Positive Regulation Of Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Cell Activation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Phosphorylation Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Induction By Virus Of Host Cell-cell Fusion Macrophage Migration Inhibitory Factor Signaling Pathway Protein Palmitoleylation Positive Regulation Of Phosphorylation Antigen Receptor-mediated Signaling Pathway
Tagcloud ?		actionable adenocarcinomas akt1 alk braf capture ccdc6 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Difference) ?		actionable adenocarcinomas akt1 alk braf capture ccdc6 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Intersection) ?