CD74 and PTCH1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CD74	PTCH1
Description		CD74 molecule	patched 1
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Vacuole Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Protein-containing Complex Macrophage Migration Inhibitory Factor Receptor Complex NOS2-CD74 Complex MHC Class II Protein Complex Lysosomal Lumen Extracellular Exosome Lumenal Side Of Endoplasmic Reticulum Membrane	Golgi Apparatus Plasma Membrane Caveola Cilium Membrane Midbody Endocytic Vesicle Membrane Dendritic Growth Cone Axonal Growth Cone Apical Part Of Cell Postsynaptic Membrane Perinuclear Region Of Cytoplasm Ciliary Membrane
	Molecular Function	Amyloid-beta Binding Cytokine Receptor Activity Protein Binding Cytokine Binding MHC Class II Protein Complex Binding Macrophage Migration Inhibitory Factor Binding MHC Class II Protein Binding CD4 Receptor Binding MHC Class II Protein Binding, Via Antigen Binding Groove Identical Protein Binding Protein Folding Chaperone Nitric-oxide Synthase Binding	Patched Binding Smoothened Binding Protein Binding Hedgehog Receptor Activity Heparin Binding Cholesterol Binding Cyclin Binding Protein-containing Complex Binding Hedgehog Family Protein Binding
	Biological Process	Prostaglandin Biosynthetic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine-mediated Signaling Pathway Adaptive Immune Response T Cell Activation Involved In Immune Response Immune System Process Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Peptide Secretion Positive Regulation Of Type 2 Immune Response Negative Regulation Of Mature B Cell Apoptotic Process Protein Folding Intracellular Protein Transport Defense Response Immune Response Positive Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Kinase Activity Response To Type II Interferon Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator T Cell Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Negative Regulation Of T Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of DNA-templated Transcription Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Fibroblast Proliferation Protein Stabilization Positive Regulation Of Macrophage Cytokine Production Protein-containing Complex Assembly Protein Trimerization Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Cell Fate Determination Neural Tube Formation Neural Tube Closure Heart Morphogenesis Signal Transduction Spermatid Development Regulation Of Mitotic Cell Cycle Pattern Specification Process Brain Development Negative Regulation Of Cell Population Proliferation Epidermis Development Regulation Of Smoothened Signaling Pathway Response To Xenobiotic Stimulus Response To Mechanical Stimulus Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Epidermal Cell Fate Specification Response To Chlorate Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Cholesterol Efflux Protein Processing Spinal Cord Motor Neuron Differentiation Neural Tube Patterning Dorsal/ventral Neural Tube Patterning Neural Plate Axis Specification Embryonic Limb Morphogenesis Prostate Gland Development Mammary Gland Development Response To Estradiol Response To Retinoic Acid Regulation Of Protein Localization Limb Morphogenesis Hindlimb Morphogenesis Regulation Of Growth Negative Regulation Of Multicellular Organism Growth Regulation Of Cell Population Proliferation Glucose Homeostasis Response To Alkaloid Keratinocyte Proliferation Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Embryonic Organ Development Smooth Muscle Tissue Development Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell Division Pharyngeal System Development Mammary Gland Duct Morphogenesis Mammary Gland Epithelial Cell Differentiation Cell Differentiation Involved In Kidney Development Somite Development Cellular Response To Cholesterol Commissural Neuron Axon Guidance Stem Cell Proliferation Cell Proliferation Involved In Metanephros Development Metanephric Collecting Duct Development Protein Localization To Plasma Membrane Liver Regeneration Negative Regulation Of Stem Cell Proliferation
Pathways		Cell surface interactions at the vascular wall MHC class II antigen presentation Developmental Lineage of Pancreatic Ductal Cells	Class B/2 (Secretin family receptors) Hedgehog 'off' state Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Hedgehog 'on' state Activation of SMO
Drugs
Diseases			Holoprosencephaly (HPE) Basal cell carcinoma Basal cell nevus syndrome; Nevoid basal cell carcinoma syndrome; Gorlin syndrome
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Post bronchodilator FEV1/FVC ratio ( 26634245)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Adventurousness ( 30643258) Alanine aminotransferase levels ( 33547301) Anxiety ( 33859377) Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Bone mineral density (hip) ( 26733130) Bone mineral density (spine) ( 26733130) Brain morphology (MOSTest) ( 32665545) Cortical surface area (visual PC2) ( 32198502) Dental caries (decayed, missing and filled teeth) ( 31533690) Feeling hurt ( 29500382) Feeling worry ( 29500382) Heel bone mineral density ( 28869591 30598549) Height ( 25429064 28552196 31562340 18391952 25282103) Hip circumference adjusted for BMI ( 34021172 25673412) Hip index ( 34021172) Infant length ( 25281659) Kidney volume ( 34128465) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung volume ( 34128465) Macular thickness ( 30535121) Monobrow ( 27182965) Neurociticism ( 29500382) Nonsyndromic cleft lip with cleft palate ( 28232668) Offspring birth weight ( 31043758) Optic disc size ( 31809533) Pulmonary function ( 20010835) Pulmonary function (smoking interaction) ( 23284291) Serum alkaline phosphatase levels ( 33547301) Thiopurine-induced pancreatitis in inflammatory bowel disease ( 29923122) Type 2 diabetes ( 32499647) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 34021172 25673412)
Interacting Genes		45 interacting genes: APP BET1 C14orf180 CCR1 CD1D CD44 CLDN19 CLEC7A CMTM7 CTSF CTSL DSCR9 EDDM3B ERG28 FDFT1 FXYD6 HADHA HLA-DMA HLA-DMB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRA LAMTOR5 LPAR3 MAP3K1 MIF PGA4 PLP1 PLPP4 POMGNT1 PTCH1 RTP2 SEC22A SERP1 SLC35B1 SMIM1 TEX11 TMEM120B TMEM243 TMEM254 TMEM60 TMEM97 UPK2	21 interacting genes: APPBP2 ATG101 ATM CCNB1 CD200R1 CD74 CD79A CDK1 CREB3 DHH FAM209A HIBADH HIPK2 IHH SHH SIGLEC12 SMO STOM TMPRSS2 TSPAN8 YAP1
Entrez ID		972	5727
HPRD ID		00825	03200
Ensembl ID		ENSG00000019582	ENSG00000185920
Uniprot IDs		P04233	A0A0C4DGJ5 A0A1W5YLI7 Q13635
PDB IDs		1A6A 1ICF 1IIE 1L3H 1MUJ 3PDO 3PGC 3PGD 3QXA 3QXD 4AEN 4AH2 4X5W 5KSU 5KSV 7YX9 7YXB 7Z0Q 8VRW 8VSJ 8VSP 9CYL 9CYM	6DMB 6DMO 6DMY 6E1H 6N7G 6N7H 6N7K 6OEU 6OEV 6RMG 6RTW 6RTX 6RTY 6RVC 6RVD
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Exogenous Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation MHC Class II Protein Complex Binding Peptide Antigen Binding Lysosome Positive Regulation Of Cell Activation MHC Class II Receptor Activity Late Endosome Membrane Membrane Positive Regulation Of Lymphocyte Activation Lumenal Side Of Endoplasmic Reticulum Membrane Endocytic Vesicle Membrane Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Transport Vesicle Membrane Positive Regulation Of T Cell Activation Trans-Golgi Network Membrane Lysosomal Membrane ER To Golgi Transport Vesicle Membrane Regulation Of Leukocyte Cell-cell Adhesion Cell Surface Regulation Of Cell Activation Regulation Of Lymphocyte Activation Adaptive Immune Response Clathrin-coated Endocytic Vesicle Membrane Positive Regulation Of Immune System Process Immune System Process Endoplasmic Reticulum Regulation Of Immune Response Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Immune Response Regulation Of T Cell Activation Immune Response Endoplasmic Reticulum Membrane Positive Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Positive Regulation Of Type II Interferon Production Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Leukocyte Proliferation Plasma Membrane Endosome	Patched Binding Cholesterol-protein Transferase Activity Protein Autoprocessing Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Self Proteolysis Positive Regulation Of Organ Growth Regulation Of Cell Population Proliferation Somite Development Cyclin B1-CDK1 Complex Intein-mediated Protein Splicing Embryonic Heart Tube Morphogenesis Smooth Muscle Tissue Development Cell Fate Specification Developmental Growth Cell Development Regulation Of Organ Growth Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Smoothened Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Epithelial Tube Morphogenesis Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Heart Growth Positive Regulation Of Protein Import Into Nucleus Epithelial-mesenchymal Cell Signaling Cell Population Proliferation Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of T Cell Differentiation Regulation Of Protein Localization To Nucleus Positive Regulation Of T Cell Differentiation In Thymus Spinal Cord Dorsal/ventral Patterning Anterior/posterior Pattern Specification Positive Regulation Of Developmental Growth Positive Regulation Of Nucleobase-containing Compound Metabolic Process Developmental Process Involved In Reproduction Negative Regulation Of Lymphocyte Activation Regulation Of Growth Ventricular Cardiac Muscle Cell Development Negative Regulation Of Lymphocyte Differentiation Positive Regulation Of Viral Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of T Cell Differentiation In Thymus
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