CD74 and CD1D

Number of citations of the paper that reports this interaction (PubMedID 11754812)
0

Data Source:
HPRD (in vivo)

		CD74	CD1D
Description		CD74 molecule	CD1d molecule
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Vacuole Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Protein-containing Complex Macrophage Migration Inhibitory Factor Receptor Complex NOS2-CD74 Complex MHC Class II Protein Complex Lysosomal Lumen Extracellular Exosome Lumenal Side Of Endoplasmic Reticulum Membrane	Extracellular Space Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	Amyloid-beta Binding Cytokine Receptor Activity Protein Binding Cytokine Binding MHC Class II Protein Complex Binding Macrophage Migration Inhibitory Factor Binding MHC Class II Protein Binding CD4 Receptor Binding MHC Class II Protein Binding, Via Antigen Binding Groove Identical Protein Binding Protein Folding Chaperone Nitric-oxide Synthase Binding	Protein Binding Beta-2-microglobulin Binding Lipid Antigen Binding Endogenous Lipid Antigen Binding Exogenous Lipid Antigen Binding Cell Adhesion Molecule Binding Lipopeptide Binding
	Biological Process	Prostaglandin Biosynthetic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine-mediated Signaling Pathway Adaptive Immune Response T Cell Activation Involved In Immune Response Immune System Process Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Peptide Secretion Positive Regulation Of Type 2 Immune Response Negative Regulation Of Mature B Cell Apoptotic Process Protein Folding Intracellular Protein Transport Defense Response Immune Response Positive Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Kinase Activity Response To Type II Interferon Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator T Cell Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Negative Regulation Of T Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of DNA-templated Transcription Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Fibroblast Proliferation Protein Stabilization Positive Regulation Of Macrophage Cytokine Production Protein-containing Complex Assembly Protein Trimerization Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway	Positive Regulation Of T Cell Mediated Cytotoxicity Immune System Process Immune Response Detection Of Bacterium Heterotypic Cell-cell Adhesion Positive Regulation Of T Cell Proliferation T Cell Selection Innate Immune Response Positive Regulation Of Innate Immune Response Antigen Processing And Presentation, Endogenous Lipid Antigen Via MHC Class Ib Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib
Pathways		Cell surface interactions at the vascular wall MHC class II antigen presentation Developmental Lineage of Pancreatic Ductal Cells	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs			cis-tetracosenoyl sulfatide
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Post bronchodilator FEV1/FVC ratio ( 26634245)	Dental caries (decayed and filled deciduous teeth) ( 31533690)
Interacting Genes		45 interacting genes: APP BET1 C14orf180 CCR1 CD1D CD44 CLDN19 CLEC7A CMTM7 CTSF CTSL DSCR9 EDDM3B ERG28 FDFT1 FXYD6 HADHA HLA-DMA HLA-DMB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRA LAMTOR5 LPAR3 MAP3K1 MIF PGA4 PLP1 PLPP4 POMGNT1 PTCH1 RTP2 SEC22A SERP1 SLC35B1 SMIM1 TEX11 TMEM120B TMEM243 TMEM254 TMEM60 TMEM97 UPK2	7 interacting genes: B2M CALR CANX CD74 P4HB PTPRC TRB
Entrez ID		972	912
HPRD ID		00825	01780
Ensembl ID		ENSG00000019582	ENSG00000158473
Uniprot IDs		P04233	A0A669KAZ2 A0A669KB34 P15813
PDB IDs		1A6A 1ICF 1IIE 1L3H 1MUJ 3PDO 3PGC 3PGD 3QXA 3QXD 4AEN 4AH2 4X5W 5KSU 5KSV 7YX9 7YXB 7Z0Q 8VRW 8VSJ 8VSP 9CYL 9CYM	1ZT4 2PO6 3HUJ 3SDX 3TZV 3U0P 3VWJ 3VWK 4EN3 4LHU 4MNG 4MQ7 4WO4 4WW2 4WWK 6V7Y 6V7Z 6V80 8SGB 8SGM 8SOS
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Exogenous Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation MHC Class II Protein Complex Binding Peptide Antigen Binding Lysosome Positive Regulation Of Cell Activation MHC Class II Receptor Activity Late Endosome Membrane Membrane Positive Regulation Of Lymphocyte Activation Lumenal Side Of Endoplasmic Reticulum Membrane Endocytic Vesicle Membrane Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Transport Vesicle Membrane Positive Regulation Of T Cell Activation Trans-Golgi Network Membrane Lysosomal Membrane ER To Golgi Transport Vesicle Membrane Regulation Of Leukocyte Cell-cell Adhesion Cell Surface Regulation Of Cell Activation Regulation Of Lymphocyte Activation Adaptive Immune Response Clathrin-coated Endocytic Vesicle Membrane Positive Regulation Of Immune System Process Immune System Process Endoplasmic Reticulum Regulation Of Immune Response Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Immune Response Regulation Of T Cell Activation Immune Response Endoplasmic Reticulum Membrane Positive Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Positive Regulation Of Type II Interferon Production Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Leukocyte Proliferation Plasma Membrane Endosome	Protein Folding Protein Folding In Endoplasmic Reticulum Endoplasmic Reticulum Lumen External Side Of Plasma Membrane Lumenal Side Of Endoplasmic Reticulum Membrane Positive Regulation Of Endocytosis Positive Regulation Of Cell Adhesion Extracellular Exosome MHC Class I Peptide Loading Complex Regulation Of Endocytosis Peptide Antigen Assembly With MHC Class I Protein Complex Endoplasmic Reticulum Regulation Of Cell Adhesion Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Thymic T Cell Selection Negative Thymic T Cell Selection Regulation Of Immune System Process Negative T Cell Selection Lymphocyte Mediated Immunity Positive T Cell Selection Positive Regulation Of Viral Entry Into Host Cell MHC Class II Protein Complex Focal Adhesion Heparan Sulfate Proteoglycan Binding Regulation Of Cell Migration Endocytic Vesicle Lumen T Cell Mediated Cytotoxicity Leukocyte Mediated Immunity Regulation Of Cell Motility Positive Regulation Of Immune System Process Positive Regulation Of Leukocyte Migration Regulation Of Viral Entry Into Host Cell Thymic T Cell Selection Regulation Of Locomotion Response To Stress Protein Transport Endoplasmic Reticulum Quality Control Compartment Positive Regulation Of Viral Life Cycle MHC Class II Protein Complex Binding Regulation Of Vesicle-mediated Transport Negative Regulation Of Multicellular Organismal Process Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Migration Antigen Processing And Presentation Of Endogenous Antigen T Cell Selection Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
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