ANXA7 and RPA1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		ANXA7	RPA1
Gene Name		annexin A7	replication protein A1, 70kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Chromaffin Granule Membrane Extracellular Vesicular Exosome	Lateral Element Male Germ Cell Nucleus Nucleus Nucleoplasm DNA Replication Factor A Complex PML Body
	Molecular Function	Integrin Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Poly(A) RNA Binding Calcium-dependent Protein Binding	Chromatin Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Cellular Calcium Ion Homeostasis Autophagy Hemostasis Cell Proliferation Regulation Of Cell Shape Response To Salt Stress Cellular Water Homeostasis Negative Regulation Of Gene Expression Response To Organic Cyclic Compound Epithelial Cell Differentiation Social Behavior Response To Calcium Ion Membrane Fusion	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly In Utero Embryonic Development DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Double-strand Break Repair DNA Recombination Meiotic Nuclear Division Positive Regulation Of Cell Proliferation Hemopoiesis Telomere Maintenance Via Semi-conservative Replication Cellular Response To Heat Homeostasis Of Number Of Cells Within A Tissue Regulation Of Cellular Response To Heat
Pathways			HSF1 activation Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Repair synthesis for gap-filling by DNA polymerase in TC-NER Activation of the pre-replicative complex DNA strand elongation Mismatch Repair G1/S Transition Homologous recombination repair of replication-independent double-strand breaks Mitotic G1-G1/S phases Removal of the Flap Intermediate from the C-strand Chromosome Maintenance DNA Replication Pre-Initiation S Phase Removal of the Flap Intermediate Global Genomic NER (GG-NER) Nucleotide Excision Repair Activation of the pre-replicative complex Extension of Telomeres Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Assembly of the RAD51-ssDNA nucleoprotein complex Telomere Maintenance Activation of ATR in response to replication stress Processing of DNA double-strand break ends Double-Strand Break Repair Dual incision reaction in GG-NER Meiotic recombination Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand M/G1 Transition Cellular response to heat stress Regulation of HSF1-mediated heat shock response Telomere C-strand (Lagging Strand) Synthesis Presynaptic phase of homologous DNA pairing and strand exchange Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Homologous DNA pairing and strand exchange Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Transcription-coupled NER (TC-NER) Homologous Recombination Repair Formation of incision complex in GG-NER Cell Cycle Checkpoints
Drugs
Diseases
GWAS
Protein-Protein Interactions		108 interactors: A1BG A2M ACTB ACTL6B ADAMTS10 ANGPT2 APC APLP1 ATP5B ATP6V1A ATXN3 BAG6 C14orf1 CCDC90B CCT7 CDK4 CELF3 CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE2 CPNE6 CPSF3L CRMP1 CSAD CTSB DDAH2 DMPK DOCK7 DVL1 DYNC1I1 EEF1A1 EXT2 F13A1 FAF1 FBN3 FGB FLAD1 GAPDH GBP2 GDF9 GNB2 GNB5 HADHB HMGXB3 HOXD8 INPP5K KLHL23 KMT2B LRIF1 MED31 MPPED1 MSH2 NGFR NMT2 NPRL2 OTUB1 PAAF1 PAX8 PDCD6 PDHB PKM PLD3 PRKACA PRKCA PRKCB PRKCG PRKG1 PSMB10 QARS RBBP4 RBM48 RPA1 RPL13 RPS2 S100A10 SDF4 SEMA5B SETDB1 SMPD1 SP110 SRC SRI SUMO3 TAF5L TIAM2 TLE1 TMEM108 TMSB4X TP53 TRMT2A TUBA1A TUBB2B TUBB3 UBE2D1 UCHL5 UNC119 USP4 VIM WDR18 WDR73 ZBTB16 ZNF135 ZNF431	63 interactors: AICDA AKTIP ANXA1 ANXA7 ASCC2 ATM ATRIP BID BLM BRCA2 BRIP1 CCNA1 CCNA2 CCNB1 CDC5L CDK1 CDK2 CPE CSNK2B DMC1 EXO5 GNB5 HAX1 HELB HGH1 HNRNPUL1 HUS1 MCM2 MCM4 MCM6 MCM7 MSH4 MTUS2 MUTYH ORC2 ORC6 PAXIP1 PCNA POLL PRKDC PRPF19 RAD1 RAD23B RAD51 RAD52 RAD9A RBM23 RCC1 RECQL RPA2 RPA3 RPA4 RPS6KA5 SELENBP1 SMAD3 TCEA2 TK1 TP53 TREX1 VIM WRN XPA XPC
Entrez ID		310	6117
HPRD ID		01720	01565
Ensembl ID		ENSG00000138279	ENSG00000132383
Uniprot IDs		B2R657 P20073	P27694
PDB IDs			1EWI 1FGU 1JMC 1L1O 2B29 2B3G 4IJH 4IJL 4IPC 4IPD 4IPG 4IPH
Enriched GO Terms of Interacting Partners?		Anatomical Structure Development Multicellular Organismal Development Developmental Process System Development Cellular Metabolic Process Metabolic Process Cellular Response To Organic Substance Platelet Activation Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Blood Coagulation Response To Growth Factor Programmed Cell Death Hemostasis Negative Regulation Of Cellular Protein Metabolic Process Cell Death Catabolic Process Death Response To Organic Substance Apoptotic Process Histone H3-T6 Phosphorylation Regulation Of Apoptotic Process Nervous System Development Regulation Of Body Fluid Levels Negative Regulation Of Protein Metabolic Process Regulation Of Cell Death Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Regulation Of Proteolysis Mitotic Cell Cycle Process Negative Regulation Of Glucose Transport Organelle Organization Cell Activation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Catalytic Activity Cellular Process Regulation Of Cellular Response To Insulin Stimulus Wound Healing Cellular Response To Stimulus Regulation Of Proteasomal Protein Catabolic Process Gene Expression Protein Metabolic Process Mitotic Cell Cycle Organ Development Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Chromosome Organization	DNA Metabolic Process Cellular Response To DNA Damage Stimulus DNA Repair DNA Replication Cellular Response To Stress Cell Cycle Process Cell Cycle DNA Damage Checkpoint Nucleobase-containing Compound Metabolic Process DNA-dependent DNA Replication Cellular Nitrogen Compound Metabolic Process DNA Recombination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Chromosome Organization Cell Cycle Checkpoint Nitrogen Compound Metabolic Process Mitotic Cell Cycle Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Response To Stress Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Regulation Of Cell Cycle Response To Ionizing Radiation DNA Conformation Change Nucleotide-excision Repair Mitotic DNA Damage Checkpoint Organelle Organization DNA Catabolic Process Regulation Of Cell Cycle Process Mitotic DNA Integrity Checkpoint Response To Radiation Mitotic Cell Cycle Checkpoint Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Cell Cycle Phase Transition DNA Strand Elongation Involved In DNA Replication Cellular Response To Stimulus Response To Abiotic Stimulus DNA Strand Elongation Signal Transduction In Response To DNA Damage Cellular Response To Ionizing Radiation Cellular Macromolecule Biosynthetic Process
Tagcloud ?		annexin anticancer antitumor chinese cytotoxic cytotoxicity decreasing depressed dramatically eecp ethanol exerted explored huvecs kappa mb mcf mda mitochondrial mu obviously p65 possess propolis ros umbilical upregulating vein	200a arthroplasty backgroundischemia conclusionsin david deeper degs downloaded gabp geo insults inverted ipc kegg limma mark0 mark1 meanwhile methodsgse21164 mir141 omnibus package ppi preconditioning reperfused resultssignificantly string t0 t1
Tagcloud (Difference) ?		annexin anticancer antitumor chinese cytotoxic cytotoxicity decreasing depressed dramatically eecp ethanol exerted explored huvecs kappa mb mcf mda mitochondrial mu obviously p65 possess propolis ros umbilical upregulating vein	200a arthroplasty backgroundischemia conclusionsin david deeper degs downloaded gabp geo insults inverted ipc kegg limma mark0 mark1 meanwhile methodsgse21164 mir141 omnibus package ppi preconditioning reperfused resultssignificantly string t0 t1
Tagcloud (Intersection) ?