RPA1 and CDK1

Number of citations of the paper that reports this interaction (PMID 8397207)
10

Data Source:
BioGRID (enzymatic study, enzymatic study)

		RPA1	CDK1
Gene Name		replication protein A1, 70kDa	cyclin-dependent kinase 1
Image
Gene Ontology Annotations	Cellular Component	Lateral Element Male Germ Cell Nucleus Nucleus Nucleoplasm DNA Replication Factor A Complex PML Body	Nucleus Nucleoplasm Cytoplasm Mitochondrion Centrosome Cytosol Spindle Microtubule Membrane Midbody Extracellular Vesicular Exosome Mitotic Spindle
	Molecular Function	Chromatin Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Metal Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity Cyclin Binding Hsp70 Protein Binding Histone Kinase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly In Utero Embryonic Development DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Double-strand Break Repair DNA Recombination Meiotic Nuclear Division Positive Regulation Of Cell Proliferation Hemopoiesis Telomere Maintenance Via Semi-conservative Replication Cellular Response To Heat Homeostasis Of Number Of Cells Within A Tissue Regulation Of Cellular Response To Heat	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Microtubule Cytoskeleton Organization Mitotic Cell Cycle Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway DNA Replication DNA Repair Protein Complex Assembly Apoptotic Process Organelle Organization Mitotic Nuclear Division Mitotic Nuclear Envelope Disassembly Mitotic G2 DNA Damage Checkpoint Centrosome Cycle Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Pronuclear Fusion Axon Guidance Cell Aging Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Toxic Substance Positive Regulation Of Gene Expression Regulation Of Schwann Cell Differentiation Response To Organic Cyclic Compound Response To Amine Response To Activity Cell Migration Histone Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Chromosome Condensation Epithelial Cell Differentiation Organ Regeneration Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Protein Localization To Kinetochore TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Response To Drug Negative Regulation Of Apoptotic Process Innate Immune Response Response To Ethanol Positive Regulation Of DNA Replication Positive Regulation Of Mitotic Cell Cycle Regulation Of Embryonic Development Response To Cadmium Ion Response To Copper Ion Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Response To Axon Injury Cell Division Stress-activated MAPK Cascade Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Hydrogen Peroxide
Pathways		HSF1 activation Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Repair synthesis for gap-filling by DNA polymerase in TC-NER Activation of the pre-replicative complex DNA strand elongation Mismatch Repair G1/S Transition Homologous recombination repair of replication-independent double-strand breaks Mitotic G1-G1/S phases Removal of the Flap Intermediate from the C-strand Chromosome Maintenance DNA Replication Pre-Initiation S Phase Removal of the Flap Intermediate Global Genomic NER (GG-NER) Nucleotide Excision Repair Activation of the pre-replicative complex Extension of Telomeres Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Assembly of the RAD51-ssDNA nucleoprotein complex Telomere Maintenance Activation of ATR in response to replication stress Processing of DNA double-strand break ends Double-Strand Break Repair Dual incision reaction in GG-NER Meiotic recombination Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand M/G1 Transition Cellular response to heat stress Regulation of HSF1-mediated heat shock response Telomere C-strand (Lagging Strand) Synthesis Presynaptic phase of homologous DNA pairing and strand exchange Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Homologous DNA pairing and strand exchange Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Transcription-coupled NER (TC-NER) Homologous Recombination Repair Formation of incision complex in GG-NER Cell Cycle Checkpoints	Phosphorylation of the APC/C Signaling by FGFR in disease Phosphorylation of Emi1 Signaling by EGFRvIII in Cancer Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Mitotic G1-G1/S phases SHC-mediated signalling Recruitment of mitotic centrosome proteins and complexes TRIF-mediated TLR3/TLR4 signaling ERK1 activation Nuclear Pore Complex (NPC) Disassembly APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase ERK1 activation APC/C:Cdc20 mediated degradation of Cyclin B Signaling by VEGF Resolution of Sister Chromatid Cohesion Downstream signal transduction Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Interleukin-2 signaling Mitotic G2-G2/M phases Frs2-mediated activation MASTL Facilitates Mitotic Progression Axon guidance IRS-mediated signalling G2/M Transition VEGFA-VEGFR2 Pathway Activated TLR4 signalling VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling Cyclin A/B1 associated events during G2/M transition Loss of Nlp from mitotic centrosomes MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Condensation of Prometaphase Chromosomes Signaling by Insulin receptor E2F mediated regulation of DNA replication Insulin receptor signalling cascade Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes G0 and Early G1 Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) E2F-enabled inhibition of pre-replication complex formation Regulation of mitotic cell cycle Cell Cycle Checkpoints Signaling by GPCR G2/M Checkpoints Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization FCERI mediated MAPK activation Regulation of PLK1 Activity at G2/M Transition SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling G1/S Transition G1/S-Specific Transcription Toll Like Receptor 9 (TLR9) Cascade G2/M DNA replication checkpoint Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 APC/C-mediated degradation of cell cycle proteins Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Condensation of Prophase Chromosomes Signaling by Leptin Signalling to ERKs Mitotic Prometaphase Prolonged ERK activation events Organelle biogenesis and maintenance ERK activation Toll Like Receptor 7/8 (TLR7/8) Cascade Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Envelope Breakdown IGF1R signaling cascade Recruitment of NuMA to mitotic centrosomes Cyclin B2 mediated events Toll Like Receptor TLR6:TLR2 Cascade M Phase IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Signalling by NGF SOS-mediated signalling G2/M DNA damage checkpoint MAP kinase activation in TLR cascade SHC-mediated signalling Depolymerisation of the Nuclear Lamina Assembly of the primary cilium Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic SHC1 events in EGFR signaling Loss of proteins required for interphase microtubule organizationÂ from the centrosome FRS2-mediated cascade IRS-mediated signalling Centrosome maturation
Drugs			Indirubin-3\'-Monoxime Olomoucine Hymenialdisine SU9516 Flavopiridol Alsterpaullone
Diseases
GWAS
Protein-Protein Interactions		63 interactors: AICDA AKTIP ANXA1 ANXA7 ASCC2 ATM ATRIP BID BLM BRCA2 BRIP1 CCNA1 CCNA2 CCNB1 CDC5L CDK1 CDK2 CPE CSNK2B DMC1 EXO5 GNB5 HAX1 HELB HGH1 HNRNPUL1 HUS1 MCM2 MCM4 MCM6 MCM7 MSH4 MTUS2 MUTYH ORC2 ORC6 PAXIP1 PCNA POLL PRKDC PRPF19 RAD1 RAD23B RAD51 RAD52 RAD9A RBM23 RCC1 RECQL RPA2 RPA3 RPA4 RPS6KA5 SELENBP1 SMAD3 TCEA2 TK1 TP53 TREX1 VIM WRN XPA XPC	174 interactors: ABL1 AMPH APLP2 AR ARID4A BCL2 BIRC5 BIRC6 BRCA1 BRCA2 BTRC BUB1 CALD1 CCNA1 CCNA2 CCNB1 CCNB2 CCNE1 CCP110 CD8A CDC25A CDC25B CDC25C CDC6 CDCA2 CDCA5 CDK7 CDKN1A CDKN3 CDT1 CEP55 CHAF1B CIITA CKS1B CKS2 CNOT7 CREM CSN2 CSNK2A1 CSNK2B CUX1 CXCR1 DAB2 DCTN6 DNM2 DUT E2F1 ECT2 EEF1D EEF2K EP300 EPN1 ERCC2 EZH2 FANCA FANCC FANCG FBXO5 FEN1 FOXM1 FYN FZR1 GADD45A GADD45B GADD45G GFAP GOLGA2 GORASP1 H1F0 HIST1H1A HIST1H1B HIST1H1D HIST1H2AB HIST1H2BB HIST1H4A HMGA1 HMGA2 HMGB1 HSPA2 HTRA2 IL16 IL3RA ITPR1 JAK3 KAT5 KHDRBS1 KIF11 KIF20B KIF26B KMT2E KRT18 LATS1 LMNA LMNB1 LYN LZTS1 MAP4 MAPT MARCKS MBP MCM4 MDM4 MEF2C MKI67 MLKL MNDA MYC MYT1 NCAPD2 NCAPG NCAPH NCL NDE1 NES NPM1 NSFL1C NUP210 PAK6 PBK PCNA PIN1 PITPNM1 PKMYT1 PLEC PML POLA1 PPP2R1A PPP2R1B PRC1 PTCH1 PTMA PTPN1 PTPN2 PTTG1 RAB4A RAB5B RACGAP1 RAP1GAP RB1 RCC1 RELB REPS2 RGCC RPA1 RPA2 RPS6KB1 RRM2 RUNX1 RUNX2 SFN SP1 SPAG5 SQSTM1 SSBP1 STMN1 STMN2 TFDP1 TGFBR2 TK1 TLE1 TNNC1 TOP2A TP53 TP53BP1 TP73 TSC1 TSPYL2 UBA1 UBE2A UHRF2 USP16 VIM WEE1 ZBTB16
Entrez ID		6117	983
HPRD ID		01565	00302
Ensembl ID		ENSG00000132383	ENSG00000170312
Uniprot IDs		P27694	B7Z3D6 I6L9I5 P06493
PDB IDs		1EWI 1FGU 1JMC 1L1O 2B29 2B3G 4IJH 4IJL 4IPC 4IPD 4IPG 4IPH	1LC9
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process Cellular Response To DNA Damage Stimulus DNA Repair DNA Replication Cellular Response To Stress Cell Cycle Process Cell Cycle DNA Damage Checkpoint Nucleobase-containing Compound Metabolic Process DNA-dependent DNA Replication Cellular Nitrogen Compound Metabolic Process DNA Recombination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Chromosome Organization Cell Cycle Checkpoint Nitrogen Compound Metabolic Process Mitotic Cell Cycle Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Response To Stress Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Regulation Of Cell Cycle Response To Ionizing Radiation DNA Conformation Change Nucleotide-excision Repair Mitotic DNA Damage Checkpoint Organelle Organization DNA Catabolic Process Regulation Of Cell Cycle Process Mitotic DNA Integrity Checkpoint Response To Radiation Mitotic Cell Cycle Checkpoint Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Cell Cycle Phase Transition DNA Strand Elongation Involved In DNA Replication Cellular Response To Stimulus Response To Abiotic Stimulus DNA Strand Elongation Signal Transduction In Response To DNA Damage Cellular Response To Ionizing Radiation Cellular Macromolecule Biosynthetic Process	Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Regulation Of Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Organelle Organization Cell Division Regulation Of Cell Cycle Process Mitotic Nuclear Division Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Cellular Response To Stress Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus DNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Kinase Activity Programmed Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Apoptotic Process Cell Death Death Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Response To Stimulus Regulation Of Organelle Organization Negative Regulation Of Cell Cycle Developmental Process Regulation Of Cell Proliferation Regulation Of Cell Division Cellular Process Response To Stress Regulation Of Cellular Process Anatomical Structure Development Chromosome Organization Positive Regulation Of Gene Expression Response To Stimulus Cell Differentiation Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		200a arthroplasty backgroundischemia conclusionsin david deeper degs downloaded gabp geo insults inverted ipc kegg limma mark0 mark1 meanwhile methodsgse21164 mir141 omnibus package ppi preconditioning reperfused resultssignificantly string t0 t1	137cs abundance accordingly alteration arrested caffeine cdk2 checkpoint constitutively culturing cytometry delayed diminished g2 hyperphosphorylation inactivation irradiated irradiation mcf monitored overexpressed pronounced qualities radiation regard scl unchanged uv whose
Tagcloud (Difference) ?		200a arthroplasty backgroundischemia conclusionsin david deeper degs downloaded gabp geo insults inverted ipc kegg limma mark0 mark1 meanwhile methodsgse21164 mir141 omnibus package ppi preconditioning reperfused resultssignificantly string t0 t1	137cs abundance accordingly alteration arrested caffeine cdk2 checkpoint constitutively culturing cytometry delayed diminished g2 hyperphosphorylation inactivation irradiated irradiation mcf monitored overexpressed pronounced qualities radiation regard scl unchanged uv whose
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