BIRC8 and UBE2G2

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		BIRC8	UBE2G2
Description		baculoviral IAP repeat containing 8	ubiquitin conjugating enzyme E2 G2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Endoplasmic Reticulum Lipid Droplet Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Zinc Ion Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Identical Protein Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Apoptotic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of Canonical Wnt Signaling Pathway	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Response To Interferon-beta ERAD Pathway Protein K48-linked Ubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 33547301)
Interacting Genes		14 interacting genes: CASP9 FAM107A MAGED1 TNPO2 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G2 UBE2K UBE2N UBE2V1 UBE2W	41 interacting genes: AMFR ARL14 AUP1 BIRC8 CBL CNNM3 CPOX CUL9 ECPAS FARP2 HBS1L KDM2A MARCHF6 MDM2 MGRN1 MLLT6 MUL1 NDUFS4 POLR3F PRKN RBX1 RC3H1 RC3H2 RFFL RNF111 RNF146 RNF157 RNF167 RNF168 RNF26 RNF5 TMEM45B TRIM21 TRIM3 TRIM43 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4
Entrez ID		112401	7327
HPRD ID		12525	04387
Ensembl ID		ENSG00000293247	ENSG00000184787
Uniprot IDs			P60604
PDB IDs			2CYX 2KLY 2LXP 3H8K 4LAD 7LEW 8T0S
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Macromolecule Catabolic Process Protein Modification Process Protein Monoubiquitination ATP Binding Positive Regulation Of Protein Polyubiquitination Protein Metabolic Process Nucleotide Binding Transferase Activity Positive Regulation Of Protein Ubiquitination Regulation Of Protein Polyubiquitination UBC13-MMS2 Complex Catabolic Process Positive Regulation Of Post-translational Protein Modification Ubiquitin Conjugating Enzyme Complex Protein K11-linked Ubiquitination Positive Regulation Of Protein Modification Process Regulation Of Protein Ubiquitination Protein-containing Complex Positive Regulation Of Protein K63-linked Ubiquitination TORC1 Signaling Negative Regulation Of TORC1 Signaling Nucleus Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Regulation Of Post-translational Protein Modification TOR Signaling Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Regulation Of Protein K63-linked Ubiquitination Regulation Of TORC1 Signaling Ubiquitin Ligase Complex Protein Catabolic Process Regulation Of Protein Modification Process Macromolecule Metabolic Process Cellular Response To Interferon-beta Protein K6-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of TOR Signaling DNA Damage Response	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Modification Process Catabolic Process Zinc Ion Binding Transferase Activity Protein Metabolic Process Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Autoubiquitination Metal Ion Binding Macromolecule Metabolic Process ERAD Pathway Protein K63-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Monoubiquitination Protein Destabilization Protein K6-linked Ubiquitination Cellular Response To Stress Positive Regulation Of Post-translational Protein Modification Response To Endoplasmic Reticulum Stress Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Response To Stress Endoplasmic Reticulum Mannose Trimming Ubiquitin Binding Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Protein Alpha-1,2-demannosylation Protein K27-linked Ubiquitination Ubiquitin-specific Protease Binding Protein Deglycosylation Positive Regulation Of Dendrite Extension Endoplasmic Reticulum Quality Control Compartment NEDD8 Ligase Activity Regulation Of Intracellular Signal Transduction Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling
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