EHD2 and SLC2A4

Number of citations of the paper that reports this interaction (PMID 15182197)
12

Data Source:
HPRD (in vivo, in vitro)

		EHD2	SLC2A4
Gene Name		EH-domain containing 2	solute carrier family 2 (facilitated glucose transporter), member 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Caveola Endosome Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Vesicular Exosome	Multivesicular Body Cytosol Plasma Membrane Integral Component Of Plasma Membrane Coated Pit External Side Of Plasma Membrane Endomembrane System Vesicle Membrane Membrane Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle T-tubule Insulin-responsive Compartment Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Nucleic Acid Binding Calcium Ion Binding Protein Binding ATP Binding GTP Binding Hydrolase Activity Protein Domain Specific Binding	Glucose Transmembrane Transporter Activity Protein Binding D-glucose Transmembrane Transporter Activity
	Biological Process	Endocytosis Blood Coagulation Metabolic Process Cortical Actin Cytoskeleton Organization Endocytic Recycling Protein Localization To Plasma Membrane Positive Regulation Of Myoblast Fusion Positive Regulation Of Endocytic Recycling	Carbohydrate Metabolic Process Hexose Transport Pathogenesis Amylopectin Biosynthetic Process Glucose Transport Cellular Response To Insulin Stimulus Glucose Homeostasis Small Molecule Metabolic Process Response To Ethanol Glucose Import Brown Fat Cell Differentiation Transmembrane Transport Membrane Organization Cellular Response To Hypoxia Cellular Response To Osmotic Stress
Pathways		Factors involved in megakaryocyte development and platelet production	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Translocation of GLUT4 to the plasma membrane SLC-mediated transmembrane transport Hexose transport Myoclonic epilepsy of Lafora Transcriptional regulation of white adipocyte differentiation Facilitative Na+-independent glucose transporters Glycogen storage diseases Glucose transport Metabolism of carbohydrates
Drugs
Diseases
GWAS			Birth weight ( 23202124) Metabolite levels ( 22286219)
Protein-Protein Interactions		13 interactors: AP1M1 AP1M2 AP2M1 BPGM DDX56 EHBP1 PICALM PICK1 RBSN SLC2A4 SPATA24 TAGLN2 TBC1D23	38 interactors: ACOX1 ACTN1 ACTN4 AKT2 ARF3 ARFIP1 BSG C1QTNF5 CCDC116 CFL1 CTSD DAXX DLD EHD2 ESYT2 FAR1 FKBP10 GAPDH HADH HK2 HSP90AA1 IDH2 KLHL41 LNPEP MAP1S MVP P3H1 P3H4 PDIA6 PRKAR1A PSMD7 RAB7A SERPINH1 SRFBP1 STRN3 UBA52 UBE2I UBE2N
Entrez ID		30846	6517
HPRD ID		10434	00688
Ensembl ID		ENSG00000024422	ENSG00000181856
Uniprot IDs		Q9NZN4	P14672 Q05BQ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Defense Response To Virus By Virus Membrane Organization Regulation Of Defense Response To Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Cell Differentiation Clathrin-mediated Endocytosis Antigen Processing And Presentation Of Peptide Antigen Golgi Vesicle Transport Vesicle-mediated Transport Antigen Processing And Presentation Intracellular Transport Amylopectin Biosynthetic Process Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Intracellular Protein Transport Developmental Process Post-Golgi Vesicle-mediated Transport Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Establishment Of Localization In Cell Viral Process Immune System Process Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Synaptic Transmission Cellular Protein Localization Cargo Loading Into Vesicle Protein Transport Cellular Localization Iron Ion Import Into Cell Establishment Of Protein Localization Regulation Of Endocytosis DNA Methylation Involved In Embryo Development Establishment Of Vesicle Localization Vesicle Organization Pigment Granule Maturation Endosome To Melanosome Transport Glucose Import Endosomal Transport Vesicle Localization Dendritic Spine Maintenance Cellular Pigment Accumulation Synaptic Vesicle Maturation Positive Regulation Of Beta-amyloid Formation Neuronal Ion Channel Clustering Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Iron Ion Import Negative Regulation Of Actin Nucleation	Generation Of Precursor Metabolites And Energy Catabolic Process Protein Localization To Tight Junction Protein Transport Establishment Of Protein Localization Protein Localization Small Molecule Metabolic Process Organelle Organization Positive Regulation Of Transferase Activity Monocarboxylic Acid Metabolic Process Regulation Of Body Fluid Levels Antigen Processing And Presentation Of Peptide Antigen Protein Targeting Blood Coagulation Hemostasis Pyruvate Metabolic Process Intracellular Protein Transport Oxidation-reduction Process Response To Stress Protein Localization To Cell Junction Glucose Metabolic Process Antigen Processing And Presentation Regulation Of Cellular Protein Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Establishment Of Localization In Cell Protein Polyubiquitination Response To Stimulus Cellular Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Cytoskeleton Organization Protein Localization To Membrane Platelet Degranulation Immune System Process Vesicle-mediated Transport Protein Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Extracellular Matrix Organization Extracellular Structure Organization Collagen Metabolic Process Membrane Organization Actin Cytoskeleton Organization Positive Regulation Of Ligase Activity Intracellular Receptor Signaling Pathway Transport Wound Healing Multicellular Organismal Macromolecule Metabolic Process Protein Metabolic Process Regulation Of Protein Ubiquitination
Tagcloud ?		acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 enrichment fhl2 homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly	atp1a2 atp1b2 beef corpus cows diestrus follicle glandular gonadotropin lcl lf luteum manipulated nelore ovulation p4 periovulatory pof preovulatory proestrus receptivity slaughtered slc5a1 washings
Tagcloud (Difference) ?		acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 enrichment fhl2 homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly	atp1a2 atp1b2 beef corpus cows diestrus follicle glandular gonadotropin lcl lf luteum manipulated nelore ovulation p4 periovulatory pof preovulatory proestrus receptivity slaughtered slc5a1 washings
Tagcloud (Intersection) ?