EHD2 and BPGM

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		EHD2	BPGM
Description		EH domain containing 2	bisphosphoglycerate mutase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Caveola Endosome Membrane Membrane Endocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome	Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Nucleic Acid Binding Calcium Ion Binding Protein Binding ATP Binding GTP Binding Hydrolase Activity Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Metal Ion Binding	Catalytic Activity Bisphosphoglycerate Mutase Activity Phosphoglycerate Mutase Activity Protein Binding Hydrolase Activity Isomerase Activity Intramolecular Phosphotransferase Activity
	Biological Process	Endocytosis Cortical Actin Cytoskeleton Organization Endocytic Recycling Cilium Assembly Protein Localization To Plasma Membrane Plasma Membrane Tubulation Positive Regulation Of Myoblast Fusion Positive Regulation Of Endocytic Recycling	Carbohydrate Metabolic Process Glycolytic Process Nucleoside Phosphate Metabolic Process Respiratory Gaseous Exchange By Respiratory System Oxygen Transport Cellular Response To Stress Defense Response To Protozoan Erythrocyte Development Establishment Of Blood-brain Barrier Neuroinflammatory Response Carbohydrate Derivative Catabolic Process
Pathways		Factors involved in megakaryocyte development and platelet production	Glycolysis
Drugs
Diseases			Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS			Blood protein levels ( 30072576)
Interacting Genes		14 interacting genes: AP1M1 AP1M2 AP2M1 BPGM CDC42 DDX56 EHBP1 PICALM PICK1 RBSN SLC2A4 SPATA24 TAGLN2 TBC1D23	9 interacting genes: AKT1 ATF6 ATP4B CEL EGR2 EHD2 GAPDH GRB2 NEK3
Entrez ID		30846	669
HPRD ID		10434	01961
Ensembl ID		ENSG00000024422	ENSG00000172331
Uniprot IDs		Q9NZN4	A0A024R782 P07738
PDB IDs			1T8P 2A9J 2F90 2H4X 2H4Z 2H52 2HHJ 3NFY 7N3R 7N3S 7THI 8X2S
Enriched GO Terms of Interacting Partners?		Cytosol Intracellular Transport Clathrin Adaptor Complex Cellular Localization Establishment Of Localization In Cell Clathrin Adaptor Activity Clathrin-coated Vesicle Vesicle-mediated Transport Extrinsic Component Of Presynaptic Endocytic Zone Membrane Protein Transport Intracellular Protein Localization Clathrin-coated Pit Establishment Of Protein Localization AP-1 Adaptor Complex Intracellular Protein Transport Regulation Of Endocytosis Regulation Of Vesicle Size Trans-Golgi Network Membrane Regulation Of Receptor-mediated Endocytosis Clathrin-coated Endocytic Vesicle Synaptic Vesicle Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Receptor Internalization Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Endocytosis Clathrin-dependent Endocytosis Dendritic Spine Organization Vesicle Budding From Membrane Cytoplasmic Vesicle Membrane Endocytosis Clathrin-coated Vesicle Membrane Vesicle Cytoplasmic Vesicle Extracellular Exosome Neuron Projection Organization Postsynapse Organization Regulation Of Vesicle-mediated Transport Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Positive Regulation Of Receptor-mediated Endocytosis Endosomal Transport Import Into Cell Membrane Organization Receptor Internalization GBD Domain Binding Storage Vacuole Endocytic Vesicle Membrane Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Regulation Of Receptor Internalization	Insulin-like Growth Factor Receptor Signaling Pathway ER-nucleus Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Epidermal Growth Factor Receptor Signaling Pathway T Cell Costimulation Endoplasmic Reticulum Unfolded Protein Response Regulation Of Myelination Regulation Of TRNA Methylation Rhombomere 5 Structural Organization Rhombomere 3 Structural Organization Rhombomere 3 Formation Rhombomere 5 Formation Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Protein Localization To Endoplasmic Reticulum ERBB Signaling Pathway Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage Regulation Of Response To Endoplasmic Reticulum Stress TRNA (guanine-N7)-methylation Cellular Response To Rapamycin Regulation Of Autophagy Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Endodeoxyribonuclease Activity Insulin Receptor Signaling Pathway Identical Protein Binding P-type Potassium:proton Transporter Activity Potassium:proton Exchanging ATPase Complex Acetylesterase Activity Rhombomere 3 Development Positive Regulation Of Schwann Cell Differentiation Brain Segmentation Myelination Axon Ensheathment Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Peptidyl-cysteine S-nitrosylase Activity Grb2-EGFR Complex Plasma Membrane Organization Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane TORC2 Complex Binding Glucose Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process SREBP-SCAP Complex Retention In Endoplasmic Reticulum Sterol Ester Esterase Activity Regulation Of Schwann Cell Differentiation Peptidyl-cysteine S-nitrosylation GAIT Complex
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