ALAD

Description		aminolevulinate dehydratase
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Catalytic Activity Porphobilinogen Synthase Activity Zinc Ion Binding Lyase Activity Identical Protein Binding Metal Ion Binding Proteasome Core Complex Binding
	Biological Process	Response To Hypoxia Porphyrin-containing Compound Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Response To Oxidative Stress Response To Nutrient Response To Xenobiotic Stimulus Response To Herbicide Response To Toxic Substance Response To Hormone Response To Metal Ion Response To Iron Ion Response To Zinc Ion Response To Aluminum Ion Response To Ionizing Radiation Response To Vitamin B1 Response To Selenium Ion Response To Lead Ion Response To Activity Response To Nutrient Levels Response To Cobalt Ion Response To Lipopolysaccharide Tetrapyrrole Biosynthetic Process Response To Vitamin E Response To Vitamin Response To Amino Acid Response To Ethanol Response To Arsenic-containing Substance Response To Cadmium Ion Response To Mercury Ion Heme O Biosynthetic Process Protein Homooligomerization Response To Glucocorticoid Response To Methylmercury Response To Platinum Ion Response To Fatty Acid Cellular Response To Lead Ion Cellular Response To Interleukin-4 Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways		Heme biosynthesis Neutrophil degranulation
Drugs		Aminolevulinic acid Delta-Amino Valeric Acid Laevulinic Acid 4-Oxosebacic Acid Porphobilinogen 3-(2-Aminoethyl)-4-(Aminomethyl)Heptanedioic Acid 4,7-Dioxosebacic Acid 5-hydroxyvaleric acid
Diseases		Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lead levels in blood ( 25820613) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Novel Interacting Genes		1 novel interacting genes: POLE3
Interacting Genes		1 interacting genes: HUNK
Entrez ID		210
HPRD ID		00504
Ensembl ID		ENSG00000148218
Uniprot IDs		A0A140VJL9 B7Z3I9 P13716 Q6ZMU0
PDB IDs		1E51 1PV8 5HMS 5HNR
Enriched GO Terms of Interacting Partners?		CHRAC Epsilon DNA Polymerase Complex Leading Strand Elongation DNA Strand Elongation Involved In DNA Replication ATAC Complex DNA-directed DNA Polymerase Activity DNA Strand Elongation Pericentric Heterochromatin
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