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HCRTR1 and ARRB2
Number of citations of the paper that reports this interaction (PMID
21378163
)
8
Data Source:
BioGRID
(fluorescent resonance energy transfer)
HCRTR1
ARRB2
Gene Name
hypocretin (orexin) receptor 1
arrestin, beta 2
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Coated Pit
Postsynaptic Density
Basolateral Plasma Membrane
Endocytic Vesicle
Cytoplasmic Vesicle
Dendritic Spine
Postsynaptic Membrane
Molecular Function
G-protein Coupled Receptor Activity
Neuropeptide Receptor Activity
Orexin Receptor Activity
Peptide Hormone Binding
Peptide Binding
G-protein Coupled Receptor Binding
Receptor Binding
Protein Binding
Enzyme Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Alpha-1A Adrenergic Receptor Binding
Alpha-1B Adrenergic Receptor Binding
Angiotensin Receptor Binding
Type 1 Angiotensin Receptor Binding
D1 Dopamine Receptor Binding
Follicle-stimulating Hormone Receptor Binding
Type 2A Serotonin Receptor Binding
Protein Complex Binding
Protein Complex Scaffold
Protein Kinase B Binding
Mitogen-activated Protein Kinase Binding
14-3-3 Protein Binding
Biological Process
Neuropeptide Signaling Pathway
Synaptic Transmission
Feeding Behavior
Cellular Response To Hormone Stimulus
Regulation Of Circadian Sleep/wake Cycle, Sleep
Response To Peptide
G-protein Coupled Receptor Internalization
Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin
Positive Regulation Of Receptor Internalization
Transcription From RNA Polymerase II Promoter
Transforming Growth Factor Beta Receptor Signaling Pathway
Notch Signaling Pathway
Brain Development
Blood Coagulation
Adult Walking Behavior
Protein Transport
Protein Ubiquitination
Platelet Activation
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Receptor Internalization
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Synaptic Transmission, Dopaminergic
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Toll-like Receptor Signaling Pathway
Negative Regulation Of GTPase Activity
Negative Regulation Of Smooth Muscle Cell Apoptotic Process
Follicle-stimulating Hormone Signaling Pathway
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Positive Regulation Of Protein Kinase B Signaling
Positive Regulation Of Calcium Ion Transport
Cell Chemotaxis
Regulation Of Androgen Receptor Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Positive Regulation Of DNA Biosynthetic Process
Pathways
G alpha (q) signalling events
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
Class A/1 (Rhodopsin-like receptors)
Orexin and neuropeptides FF and QRFP bind to their respective receptors
GPCR ligand binding
Metabolic disorders of biological oxidation enzymes
G alpha (q) signalling events
GPCR downstream signaling
Peptide ligand-binding receptors
Gastrin-CREB signalling pathway via PKC and MAPK
Signaling by NOTCH1 HD Domain Mutants in Cancer
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
Signaling by NOTCH
Signaling by Wnt
beta-catenin independent WNT signaling
Thrombin signalling through proteinase activated receptors (PARs)
Activated NOTCH1 Transmits Signal to the Nucleus
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Hedgehog 'on' state
Signaling by NOTCH1
WNT5A-dependent internalization of FZD4
Signaling by Hedgehog
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Signaling by NOTCH1 in Cancer
Platelet activation, signaling and aggregation
PCP/CE pathway
Activation of SMO
FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions
4 interactors:
ARRB1
ARRB2
CNR1
HCRT
47 interactors:
ADRB2
AGTR1
AP1B1
AP2M1
ARF6
AVPR2
C5AR1
CDC42
CLTC
CSNK2A1
CSNK2A2
CXCR4
CYTH2
DVL2
FLNA
FZD4
HCRTR1
HIPK3
HTR2C
ITCH
LHCGR
LIMK1
MAP2K4
MAP3K5
MAPK1
MAPK10
MAPK9
MDM2
MED8
NDUFS7
NFKBIA
NTS
NTSR1
OPRD1
OXTR
PARK2
PDE4D
PTAFR
PTGDS
RAF1
RALGDS
SLC9A5
SMARCC2
STC2
TGFBR3
TRH
USP33
Entrez ID
3061
409
HPRD ID
03863
00147
Ensembl ID
ENSG00000121764
ENSG00000141480
Uniprot IDs
O43613
K7ENA6
P32121
Q59EM5
PDB IDs
Enriched GO Terms of Interacting Partners
?
G-protein Coupled Receptor Internalization
Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway
Positive Regulation Of Receptor Internalization
Regulation Of Synaptic Transmission
Regulation Of Receptor Internalization
Negative Regulation Of Interleukin-6 Production
Positive Regulation Of Receptor-mediated Endocytosis
Receptor Internalization
Regulation Of Cellular Ketone Metabolic Process
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Peptidyl-serine Phosphorylation
Behavior
Negative Regulation Of Cellular Metabolic Process
Receptor Metabolic Process
Regulation Of Ion Transport
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity
Regulation Of Secretion
Sensory Perception Of Pain
Positive Regulation Of Calcium Ion Transport
Negative Regulation Of Ion Transport
Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Negative Regulation Of Protein Ubiquitination
Regulation Of Interleukin-6 Production
Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Endocytosis
Positive Regulation Of Transport
Negative Regulation Of Catalytic Activity
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of ERK1 And ERK2 Cascade
Notch Signaling Pathway
Regulation Of Protein Binding
Regulation Of Signaling
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Detection Of Abiotic Stimulus
Cell Surface Receptor Signaling Pathway
Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin
Regulation Of Cellular Localization
Regulation Of Endocytosis
Regulation Of ERK1 And ERK2 Cascade
Regulation Of Calcium Ion Transport
Platelet Activation
Positive Regulation Of Ion Transport
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Insulin Secretion
Regulation Of Protein Ubiquitination
G-protein Coupled Receptor Signaling Pathway
Negative Regulation Of Cytokine Production
Regulation Of Cysteine-type Endopeptidase Activity
Negative Regulation Of Action Potential
Cell Surface Receptor Signaling Pathway
Cell Communication
Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Signaling
Signal Transduction
Regulation Of Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of Protein Metabolic Process
Cellular Response To Stimulus
Response To External Stimulus
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Stress-activated MAPK Cascade
Immune Response-regulating Signaling Pathway
Intracellular Signal Transduction
Cellular Response To Organic Substance
Response To Stimulus
Positive Regulation Of Signal Transduction
Regulation Of Phosphorylation
Positive Regulation Of Intracellular Signal Transduction
Regulation Of JNK Cascade
Response To Organic Substance
Positive Regulation Of MAPK Cascade
Regulation Of Protein Phosphorylation
Chemotaxis
Positive Regulation Of Protein Modification Process
Regulation Of Catalytic Activity
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Positive Regulation Of Phosphorylation
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Protein Phosphorylation
Locomotion
Immune System Process
Regulation Of Metabolic Process
Regulation Of Cellular Process
Positive Regulation Of Catalytic Activity
Positive Regulation Of Kinase Activity
Regulation Of Kinase Activity
Fc Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway
Apoptotic Process
Response To Stress
Positive Regulation Of Cellular Metabolic Process
Programmed Cell Death
Regulation Of MAP Kinase Activity
Response To Lipid
Tagcloud
?
17p13
22q11
adrbk2
adrenergic
ark
ark1
ark2
arrestin
assignment
band
chromosome
coding
cofactor
coupled
desensitization
grk4
grk5
grk6
includes
it11
mapped
mapping
multigene
occupied
phosphorylates
q37
refine
rhodopsin
sag
Tagcloud (Difference)
?
17p13
22q11
adrbk2
adrenergic
ark
ark1
ark2
arrestin
assignment
band
chromosome
coding
cofactor
coupled
desensitization
grk4
grk5
grk6
includes
it11
mapped
mapping
multigene
occupied
phosphorylates
q37
refine
rhodopsin
sag
Tagcloud (Intersection)
?