HCRTR1 and ARRB2

Number of citations of the paper that reports this interaction (PubMedID 21378163)
68

Data Source:
BioGRID (fluorescent resonance energy transfer)

		HCRTR1	ARRB2
Description		hypocretin receptor 1	arrestin beta 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Endocytic Vesicle Endocytic Vesicle Membrane Cytoplasmic Vesicle Postsynapse Glutamatergic Synapse
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Orexin Receptor Activity Peptide Hormone Binding	G Protein-coupled Receptor Binding Signaling Receptor Binding Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Angiotensin Receptor Binding D1 Dopamine Receptor Binding Protein Kinase B Binding Molecular Adaptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Cellular Response To Hormone Stimulus Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of ERK1 And ERK2 Cascade	Desensitization Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Internalization Positive Regulation Of Receptor Internalization Transcription By RNA Polymerase II Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Adult Walking Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Protein Transport Protein Ubiquitination Sensory Perception Of Pain Negative Regulation Of Protein Ubiquitination Receptor Internalization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Excitatory Postsynaptic Potential Cell Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Postsynaptic Signal Transduction Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events	Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Thrombin signalling through proteinase activated receptors (PARs) WNT5A-dependent internalization of FZD4 Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants Signaling by RAF1 mutants TGFBR3 regulates TGF-beta signaling
Drugs		Suvorexant Lemborexant Daridorexant
Diseases
GWAS		Adiponectin levels ( 33562295) Asthma ( 31959851) Body mass index ( 26426971) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Daytime nap ( 33568662) General cognitive ability ( 29844566) Hypoalbuminemia ( 34050200)	Behcet's disease ( 33393726) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: ARRB1 ARRB2 CNR1 HCRT	60 interacting genes: ADRB2 AGTR1 AGTR2 AP1B1 AP2M1 ARF6 AVPR2 BCAS1 C5AR1 CDC42 CLTC CRHR1 CSNK2A1 CSNK2A2 CXCR4 CYTH2 DLG4 DVL2 EGFR EIF2AK4 FLNA FZD4 HCRTR1 HIPK3 HTR2C ITCH LHCGR LIMK1 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK9 MAS1 MDM2 MED8 NDUFS7 NEDD4L NFKBIA NTS NTSR1 OPRD1 OXER1 OXTR PDE4D PTAFR PTGDS RAF1 RALGDS RHO SLC9A5 SMARCC2 SNCA STC2 SUMO1 SUMO2 TGFBR3 TRH UBC UBE2I
Entrez ID		3061	409
HPRD ID		03863	00147
Ensembl ID		ENSG00000121764	ENSG00000141480
Uniprot IDs		A6NMV7 O43613	K7ENA6 P32121 Q59EM5 Q68DZ5
PDB IDs		4ZJ8 4ZJC 6TO7 6TOD 6TOS 6TOT 6TP3 6TP4 6TP6 6TQ4 6TQ6 6TQ7 6TQ9 6V9S
Enriched GO Terms of Interacting Partners?		Angiotensin Receptor Binding Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Internalization Regulation Of System Process Positive Regulation Of Receptor Internalization Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Muscle System Process Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Positive Regulation Of Transport Cytoplasmic Vesicle Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Endocytic Vesicle Membrane Receptor Internalization Regulation Of Receptor Internalization G Protein-coupled Receptor Binding Negative Regulation Of DNA-binding Transcription Factor Activity Clathrin-coated Pit Negative Regulation Of Protein Ubiquitination Regulation Of Cardiac Muscle Hypertrophy Excitatory Postsynaptic Potential Type 1 Orexin Receptor Binding Type 2 Orexin Receptor Binding Regulation Of Membrane Potential Regulation Of Potassium Ion Transport Negative Regulation Of Post-translational Protein Modification Regulation Of Postsynaptic Membrane Potential Protein Transport Into Plasma Membrane Raft Cannabinoid Receptor Activity Type II Interferon Receptor Activity Poly(C) RNA Binding Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Synaptic Transmission, Dopaminergic Cannabinoid Signaling Pathway Retrograde Trans-synaptic Signaling By Endocannabinoid Signal Transduction Import Into Cell Regulation Of Interleukin-6 Production Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Transport Into Membrane Raft Positive Regulation Of Endocytosis Regulation Of Transport Cytoplasmic Vesicle Membrane Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Potassium Ion Import Across Plasma Membrane Cell Communication Protein Localization To Plasma Membrane Raft Neuronal Dense Core Vesicle Lumen	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Plasma Membrane Signal Transduction Regulation Of Biological Quality Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Multicellular Organismal Process Protein Serine Kinase Activity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Protein Kinase Activity Clathrin-coated Endocytic Vesicle Membrane Angiotensin Type II Receptor Activity Regulation Of Transport Positive Regulation Of Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Metal Ion Transport Regulation Of MAPK Cascade Regulation Of System Process Regulation Of Systemic Arterial Blood Pressure Glutamatergic Synapse Regulation Of Developmental Process Positive Regulation Of Locomotion Negative Regulation Of Systemic Arterial Blood Pressure Ubiquitin Protein Ligase Binding Enzyme Binding Blood Vessel Diameter Maintenance Regulation Of Tube Size Kinase Activity Import Into Cell Postsynapse Regulation Of Monoatomic Ion Transport Response To Stress Regulation Of Blood Pressure Neuron Spine Positive Regulation Of Neuron Projection Arborization Endocytosis Positive Regulation Of Cell Migration
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