HCRTR1

Gene Name		hypocretin (orexin) receptor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Activity Neuropeptide Receptor Activity Orexin Receptor Activity Peptide Hormone Binding Peptide Binding
	Biological Process	Neuropeptide Signaling Pathway Synaptic Transmission Feeding Behavior Cellular Response To Hormone Stimulus Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Peptide
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Orexin and neuropeptides FF and QRFP bind to their respective receptors GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: ARRB1 ARRB2 CNR1 HCRT
Entrez ID		3061
HPRD ID		03863
Ensembl ID		ENSG00000121764
Uniprot IDs		O43613
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Internalization Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Receptor Internalization Regulation Of Synaptic Transmission Regulation Of Receptor Internalization Negative Regulation Of Interleukin-6 Production Positive Regulation Of Receptor-mediated Endocytosis Receptor Internalization Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Behavior Negative Regulation Of Cellular Metabolic Process Receptor Metabolic Process Regulation Of Ion Transport Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Secretion Sensory Perception Of Pain Positive Regulation Of Calcium Ion Transport Negative Regulation Of Ion Transport Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Protein Ubiquitination Regulation Of Interleukin-6 Production Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Endocytosis Positive Regulation Of Transport Negative Regulation Of Catalytic Activity Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade Notch Signaling Pathway Regulation Of Protein Binding Regulation Of Signaling Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Cell Surface Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Regulation Of Cellular Localization Regulation Of Endocytosis Regulation Of ERK1 And ERK2 Cascade Regulation Of Calcium Ion Transport Platelet Activation Positive Regulation Of Ion Transport Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Insulin Secretion Regulation Of Protein Ubiquitination G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cytokine Production Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Action Potential
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