HCRTR1

Description		hypocretin receptor 1
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Synapse
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Orexin Receptor Activity Peptide Hormone Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Cellular Response To Hormone Stimulus Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs		Suvorexant Lemborexant Daridorexant
Diseases
GWAS		Adiponectin levels ( 33562295) Asthma ( 31959851) Body mass index ( 26426971) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Daytime nap ( 33568662) General cognitive ability ( 29844566) Hypoalbuminemia ( 34050200)
Novel Interacting Genes		3 novel interacting genes: ATP1B1 IFNGR2 PABPC4
Interacting Genes		4 interacting genes: ARRB1 ARRB2 CNR1 HCRT
Entrez ID		3061
HPRD ID		03863
Ensembl ID		ENSG00000121764
Uniprot IDs		A6NMV7 O43613
PDB IDs		4ZJ8 4ZJC 6TO7 6TOD 6TOS 6TOT 6TP3 6TP4 6TP6 6TQ4 6TQ6 6TQ7 6TQ9 6V9S
Enriched GO Terms of Interacting Partners?		Angiotensin Receptor Binding Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Internalization Regulation Of System Process Positive Regulation Of Receptor Internalization Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Muscle System Process Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Positive Regulation Of Transport Cytoplasmic Vesicle Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Endocytic Vesicle Membrane Receptor Internalization Regulation Of Receptor Internalization G Protein-coupled Receptor Binding Negative Regulation Of DNA-binding Transcription Factor Activity Clathrin-coated Pit Negative Regulation Of Protein Ubiquitination Regulation Of Cardiac Muscle Hypertrophy Excitatory Postsynaptic Potential Type 1 Orexin Receptor Binding Type 2 Orexin Receptor Binding Regulation Of Membrane Potential Regulation Of Potassium Ion Transport Negative Regulation Of Post-translational Protein Modification Regulation Of Postsynaptic Membrane Potential Protein Transport Into Plasma Membrane Raft Cannabinoid Receptor Activity Type II Interferon Receptor Activity Poly(C) RNA Binding Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Synaptic Transmission, Dopaminergic Cannabinoid Signaling Pathway Retrograde Trans-synaptic Signaling By Endocannabinoid Signal Transduction Import Into Cell Regulation Of Interleukin-6 Production Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Transport Into Membrane Raft Positive Regulation Of Endocytosis Regulation Of Transport Cytoplasmic Vesicle Membrane Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Potassium Ion Import Across Plasma Membrane Cell Communication Protein Localization To Plasma Membrane Raft Neuronal Dense Core Vesicle Lumen
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