HCRTR1 and CNR1

Number of citations of the paper that reports this interaction (PMID 12690115)
24

Data Source:
HPRD (in vivo)

		HCRTR1	CNR1
Gene Name		hypocretin (orexin) receptor 1	cannabinoid receptor 1 (brain)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Axon Growth Cone Intracellular Membrane-bounded Organelle
	Molecular Function	G-protein Coupled Receptor Activity Neuropeptide Receptor Activity Orexin Receptor Activity Peptide Hormone Binding Peptide Binding	Cannabinoid Receptor Activity Drug Binding
	Biological Process	Neuropeptide Signaling Pathway Synaptic Transmission Feeding Behavior Cellular Response To Hormone Stimulus Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Peptide	Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Spermatogenesis Axonal Fasciculation Aging Response To Nutrient Memory Positive Regulation Of Neuron Projection Development Sensory Perception Of Pain Positive Regulation Of Fever Generation Negative Regulation Of Fatty Acid Beta-oxidation Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Negative Regulation Of Mast Cell Activation Negative Regulation Of Dopamine Secretion Response To Nicotine Cannabinoid Signaling Pathway Response To Cocaine Glucose Homeostasis Positive Regulation Of Apoptotic Process Response To Morphine Response To Ethanol Negative Regulation Of Action Potential Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Regulation Of Insulin Secretion Negative Regulation Of Nitric-oxide Synthase Activity Regulation Of Synaptic Transmission, Glutamatergic Maternal Process Involved In Female Pregnancy Regulation Of Feeding Behavior Regulation Of Penile Erection
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Orexin and neuropeptides FF and QRFP bind to their respective receptors GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Dronabinol Nabilone Rimonabant
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ARRB1 ARRB2 CNR1 HCRT	6 interactors: GNA15 GNAI1 GNAI2 GNAI3 HCRTR1 MET
Entrez ID		3061	1268
HPRD ID		03863	00259
Ensembl ID		ENSG00000121764	ENSG00000118432
Uniprot IDs		O43613	P21554 S5TLS4
PDB IDs			1LVQ 1LVR 2B0Y 2KOE
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Internalization Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Receptor Internalization Regulation Of Synaptic Transmission Regulation Of Receptor Internalization Negative Regulation Of Interleukin-6 Production Positive Regulation Of Receptor-mediated Endocytosis Receptor Internalization Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Behavior Negative Regulation Of Cellular Metabolic Process Receptor Metabolic Process Regulation Of Ion Transport Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Secretion Sensory Perception Of Pain Positive Regulation Of Calcium Ion Transport Negative Regulation Of Ion Transport Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Protein Ubiquitination Regulation Of Interleukin-6 Production Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Endocytosis Positive Regulation Of Transport Negative Regulation Of Catalytic Activity Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade Notch Signaling Pathway Regulation Of Protein Binding Regulation Of Signaling Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Cell Surface Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Regulation Of Cellular Localization Regulation Of Endocytosis Regulation Of ERK1 And ERK2 Cascade Regulation Of Calcium Ion Transport Platelet Activation Positive Regulation Of Ion Transport Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Insulin Secretion Regulation Of Protein Ubiquitination G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cytokine Production Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Action Potential	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Blood Coagulation Hemostasis G-protein Coupled Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Regulation Of Body Fluid Levels Synaptic Transmission Cell Surface Receptor Signaling Pathway Wound Healing Cell Activation Response To Wounding Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Vesicle Fusion Regulation Of Adenylate Cyclase Activity Cell Division Regulation Of Cyclase Activity Signal Transduction Organelle Fusion Signaling Regulation Of CAMP Biosynthetic Process Cell Communication Regulation Of CAMP Metabolic Process Membrane Fusion Cellular Response To Stimulus Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Regulation Of Behavior Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Vesicle Organization Regulation Of Catalytic Activity Myoblast Proliferation Response To Stimulus Hepatocyte Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Endothelial Cell Chemotaxis Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Negative Regulation Of Hydrogen Peroxide-induced Cell Death Endothelial Cell Morphogenesis Cell Cycle Regulation Of Hydrogen Peroxide-induced Cell Death Adenosine Receptor Signaling Pathway Mesenchymal-epithelial Cell Signaling
Tagcloud ?			addicts alcohol alleles allocation amplitude attentional blocking cannabinoid contributed dependence electrodes erp evoked frontal homozygosity homozygous intoxication lobe lobes manova marijuana memory microsatellite reflects repeat resource variance wave working
Tagcloud (Difference) ?			addicts alcohol alleles allocation amplitude attentional blocking cannabinoid contributed dependence electrodes erp evoked frontal homozygosity homozygous intoxication lobe lobes manova marijuana memory microsatellite reflects repeat resource variance wave working
Tagcloud (Intersection) ?