HCRTR1 and CNR1

Number of citations of the paper that reports this interaction (PubMedID 12690115)
0

Data Source:
HPRD (in vivo)

		HCRTR1	CNR1
Description		hypocretin receptor 1	cannabinoid receptor 1
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Synapse	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Plasma Membrane Actin Cytoskeleton Membrane Axon Growth Cone Presynaptic Membrane Cell Projection Membrane Raft Synapse Presynapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Orexin Receptor Activity Peptide Hormone Binding	G Protein-coupled Receptor Activity Cannabinoid Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Cellular Response To Hormone Stimulus Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of ERK1 And ERK2 Cascade	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Axonal Fasciculation Cannabinoid Signaling Pathway Glucose Homeostasis Retrograde Trans-synaptic Signaling By Endocannabinoid Regulation Of Presynaptic Cytosolic Calcium Ion Concentration
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events
Drugs		Suvorexant Lemborexant Daridorexant	Dronabinol Nabilone Ricinoleic acid SLV319 V24343 AVE-1625 Rimonabant Cannabidiol Propacetamol Otenabant Tetrahydrocannabivarin Medical Cannabis Nabiximols
Diseases
GWAS		Adiponectin levels ( 33562295) Asthma ( 31959851) Body mass index ( 26426971) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Daytime nap ( 33568662) General cognitive ability ( 29844566) Hypoalbuminemia ( 34050200)	Depression in smokers ( 30219690) Gut microbiota (functional units) ( 27694959)
Interacting Genes		4 interacting genes: ARRB1 ARRB2 CNR1 HCRT	10 interacting genes: ADORA2A BECN2 GNA15 GNAI1 GNAI2 GNAI3 HCRTR1 MET NSRP1 SSTR5
Entrez ID		3061	1268
HPRD ID		03863	00259
Ensembl ID		ENSG00000121764	ENSG00000118432
Uniprot IDs		A6NMV7 O43613	P21554 S5TLS4 V5KA96
PDB IDs		4ZJ8 4ZJC 6TO7 6TOD 6TOS 6TOT 6TP3 6TP4 6TP6 6TQ4 6TQ6 6TQ7 6TQ9 6V9S	1LVQ 1LVR 2B0Y 2KOE 2MZ2 2MZ3 2MZA 5TGZ 5U09 5XR8 5XRA 6KPG 6KQI 6N4B 7FEE 7V3Z 7WV9 8GAG 8GHV 8IKG 8IKH 8K8J 8WRZ 8WU1 9B54 9B65 9B9Y 9B9Z 9BA0 9ERX
Enriched GO Terms of Interacting Partners?		Angiotensin Receptor Binding Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Internalization Regulation Of System Process Positive Regulation Of Receptor Internalization Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Muscle System Process Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Positive Regulation Of Transport Cytoplasmic Vesicle Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Endocytic Vesicle Membrane Receptor Internalization Regulation Of Receptor Internalization G Protein-coupled Receptor Binding Negative Regulation Of DNA-binding Transcription Factor Activity Clathrin-coated Pit Negative Regulation Of Protein Ubiquitination Regulation Of Cardiac Muscle Hypertrophy Excitatory Postsynaptic Potential Type 1 Orexin Receptor Binding Type 2 Orexin Receptor Binding Regulation Of Membrane Potential Regulation Of Potassium Ion Transport Negative Regulation Of Post-translational Protein Modification Regulation Of Postsynaptic Membrane Potential Protein Transport Into Plasma Membrane Raft Cannabinoid Receptor Activity Type II Interferon Receptor Activity Poly(C) RNA Binding Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Synaptic Transmission, Dopaminergic Cannabinoid Signaling Pathway Retrograde Trans-synaptic Signaling By Endocannabinoid Signal Transduction Import Into Cell Regulation Of Interleukin-6 Production Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Transport Into Membrane Raft Positive Regulation Of Endocytosis Regulation Of Transport Cytoplasmic Vesicle Membrane Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Potassium Ion Import Across Plasma Membrane Cell Communication Protein Localization To Plasma Membrane Raft Neuronal Dense Core Vesicle Lumen	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Adenosine Receptor Signaling Pathway Positive Regulation Of Urine Volume Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity GTPase Activity Neuropeptide Signaling Pathway GTP Binding Regulation Of Urine Volume G Protein-coupled Acetylcholine Receptor Signaling Pathway Purinergic Nucleotide Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Midbody Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Secretion By Cell Acetylcholine Receptor Signaling Pathway Regulation Of Secretion Postsynaptic Signal Transduction Regulation Of Protein Secretion Signal Transduction Regulation Of ERK1 And ERK2 Cascade Excitatory Postsynaptic Potential Hepatocyte Growth Factor Receptor Activity Plasma Membrane Ciliary Basal Body Regulation Of Cell Communication Regulation Of Signaling GDP Binding Feeding Behavior G Protein-coupled Receptor Activity Orexin Receptor Activity G Protein-coupled Receptor Catabolic Process Regulation Of Postsynaptic Membrane Potential Regulation Of Protein Transport Positive Regulation Of Acetylcholine Secretion, Neurotransmission Nucleotide Binding D2 Dopamine Receptor Binding Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Cell Division Positive Regulation Of MAPK Cascade Regulation Of Acetylcholine Secretion, Neurotransmission Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
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