HBD and HBQ1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		HBD	HBQ1
Name		hemoglobin subunit delta	hemoglobin subunit theta 1
Structure			No pdb structure
GO Annotations	Cellular Component	Cytosol Hemoglobin Complex Haptoglobin-hemoglobin Complex Blood Microparticle	Hemoglobin Complex Haptoglobin-hemoglobin Complex
	Molecular Function	Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Hemoglobin Alpha Binding Metal Ion Binding	Oxygen Carrier Activity Iron Ion Binding Protein Binding Oxygen Binding Heme Binding Metal Ion Binding
	Biological Process	Carbon Dioxide Transport Oxygen Transport Erythrocyte Development	Oxygen Transport Erythrocyte Development
Pathways		Factors involved in megakaryocyte development and platelet production	None
GWAS		Beta thalassemia/hemoglobin E disease ( 20183929 ) Hematology traits ( 23263863 ) Hemoglobin levels ( 26366553 ) Logical memory (delayed recall) in normal cognition ( 29274321 ) Logical memory (immediate recall) in normal cognition ( 29274321 ) Malaria ( 31844061 ) Mean corpuscular hemoglobin concentration ( 23263863 )	Hemoglobin ( 32888494 ) Hemoglobin levels ( 26366553 32327693 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular hemoglobin concentration ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 27863252 32888494 ) Red cell distribution width ( 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 )
Interacting Genes		6 interacting genes: APP HBA1 HBA2 HBM HBQ1 HBZ	10 interacting genes: AHCYL1 HBA1 HBA2 HBB HBD HBE1 HBG2 HBZ NTAQ1 RFESD
Entrez ID		3045	3049
HPRD ID		00787	00791
Ensembl ID		ENSG00000223609	ENSG00000086506
Uniprot IDs		A0N071 P02042	A0A1K0GUV5 P09105
PDB IDs		1SHR 1SI4	Not available
GO Terms Enriched among Interactors		Hemoglobin Complex Haptoglobin-hemoglobin Complex Oxygen Carrier Activity Myeloid Cell Development Oxygen Transport Oxygen Binding Erythrocyte Development Hemopoiesis Heme Binding Carbon Dioxide Transport Cell Development Iron Ion Binding One-carbon Compound Transport Haptoglobin Binding Nitric Oxide Transport G Protein-coupled Receptor Binding Endocytic Vesicle Lumen Hydrogen Peroxide Catabolic Process Cellular Developmental Process Peroxidase Activity Hydrogen Peroxide Metabolic Process Metal Ion Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Oxidant Detoxification Reactive Oxygen Species Metabolic Process Response To Hydrogen Peroxide Cellular Detoxification Acetylcholine Receptor Activator Activity Lipoprotein Particle Developmental Process Positive Regulation Of Protein Import Blood Microparticle PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cell Maturation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response	Haptoglobin-hemoglobin Complex Hemoglobin Complex Oxygen Carrier Activity Carbon Dioxide Transport Oxygen Transport One-carbon Compound Transport Oxygen Binding Erythrocyte Development Myeloid Cell Development Heme Binding Hemoglobin Alpha Binding Hemopoiesis Blood Microparticle Haptoglobin Binding Nitric Oxide Transport Cell Development Endocytic Vesicle Lumen Hydrogen Peroxide Catabolic Process Peroxidase Activity Hydrogen Peroxide Metabolic Process Cellular Oxidant Detoxification Reactive Oxygen Species Metabolic Process Response To Hydrogen Peroxide Cellular Detoxification Iron Ion Binding Response To Reactive Oxygen Species Metal Ion Binding Cellular Developmental Process Protein-N-terminal Glutamine Amidohydrolase Activity G Protein-coupled Receptor Binding Response To Oxidative Stress Adenosylhomocysteinase Activity Protein-N-terminal Asparagine Amidohydrolase Activity S-adenosylmethionine Cycle Cytosol Hemoglobin Binding Inflammatory Response Extracellular Exosome Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of MRNA 3'-end Processing S-adenosylmethionine Metabolic Process Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Developmental Process Erythrocyte Maturation Angiotensin-activated Signaling Pathway One-carbon Metabolic Process Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site 2 Iron, 2 Sulfur Cluster Binding